CURRICULUM VITAE

 

Name:   Stephen Keith Tyring, M.D., Ph.D., M.B.A.          Date: 01 June 2017

 

PRESENT POSITION AND ADDRESS

 

Clinical Professor:

Departments of Dermatology, Microbiology & Molecular Genetics and Internal                                   Medicine (Infectious Diseases)

The University of Texas Health Science Center, Houston

 Member:

           The Graduate School of Biomedical Sciences

The University of Texas Health Science Center, Houston

Adjunct Professor of Biological Sciences:

            The School of Public Health

The University of Texas Health Science Center, Houston

 

Medical Director:                                                                                           Center for Clinical Studies                      Derm Assoc Texas

styring@ccstexas.com                               styring@dermtexas.com

451 N. Texas Avenue                                20320 Northwest Freeway, Suite 700

Webster, Texas 77598                               Houston, TX 77065

Telephone:  (281) 333-2288*                     Telephone:  (713) 554-4688*

Fax: (281) 335-4605                                   Fax:  (832) 478-5662

 

1401 Binz St., Suite 200                           10907 Memorial Hermann Drive

Houston, Texas 77004                               Suite 170

Telephone: (713) 528-8818*                      Pearland, Texas 77584

Fax: (713) 528-8848                                  Telephone: (281) 864-3376*

*24 hour answering service                      Fax: (281) 864-3576

         

 

BIOGRAPHICAL

 

Date of Birth: August 22, 1949

Place of Birth: Oakland City, Indiana

Citizenship:   U.S.A.

Wife:   Patricia Lee, M.D.

 

EDUCATION

 

1967-1971       Indiana State University, B.A. (Biology/Chemistry)

1971-1973       Abilene Christian University, M.S. (Biology/Chemistry)

1975-1976       Texas A & M University (Microbiology)

1976-1979       Texas Tech University, Ph.D. (Medical Microbiology)

1979-1983       University of Texas Medical Branch, M.D.

1979-1984       University of Texas Medical Branch, Postdoctoral training

(with Dr. Samuel Baron, Chairman, Department of Microbiology)

1983-1984       University of Texas Medical Branch, Internship in Internal Medicine

  • University of Alabama in Birmingham, Resident in Dermatology

2001-2003       Rice University, Masters in Business Administration

 

 

PROFESSIONAL AND TEACHING EXPERIENCE

 

1993-2004          Professor, Departments of Dermatology, Microbiology & Immunology and Internal Medicine, UTMB

Member of Sealy Center for Vaccine Development, UTMB

Adjunct Professor of Biological Sciences (appointment 2000), UT Health Science Center at Houston, School of Public Health

  • Associate Professor, Departments of Microbiology and Immunology, Dermatology and Internal Medicine, UTMB

1987-1989          Assistant Professor, Departments of Microbiology and Dermatology, UTMB

1984-1987          Adjunct Assistant Professor of Microbiology, UTMB

1979-1984          Research Associate, Department of Microbiology, UTMB

1976-1979          Lab Instructor in medical microbiology, Texas Tech Univ. School of Medicine

  • Lab Instructor in general microbiology, Texas A & M University

1973-1975          Research Associate at Das Institut fuer Biologische Forschung, Cologne, West Germany

1971-1973          Teaching Assistantship in freshman biology labs, Abilene Christian University

 

LICENSURE INFORMATION

 

Texas, G5714

Board Certification: American Board of Dermatology

 

PROFESSIONAL SOCIETIES

 

Houston Dermatology Society

(Secretary-Treasurer 2001-2003, President 2004)

*American Dermatological Association

*Noah Worcester Dermatological Society

*Sigma Xi Research Society

*Society for Experimental Biology and Medicine

*American Federation for Clinical Research

*American Association for Cancer Research

*Infectious Disease Society of America (Fellow)

Harris County Medical Society

Texas Medical Association

Texas Dermatological Society

(member: Board of Trustees, President 2009-2010)

Southern Medical Association

American Society for Microbiology

American Academy of Dermatology

(Chair of Committee on Sexually Transmitted Diseases, 2000-2008)

(Ad hoc Task Force on Bioterrorism, 2002-present)

Society for Investigative Dermatology

(President of Southern Section, 1991-1992)

(Committee on Long-range Planning and Priorities, 2002-present)

American Medical Association

American Association for the Advancement of Science

American Association of University Professors

Dermatology Foundation (member of Medical and Scientific Committee 1997-2000)

Dermatology Foundation, Annenberg Circle

Dermatology Foundation, Vice-Chair Leaders Society

Dermatology Foundation, Board of Trustees

International Society of Dermatology

International Society for Interferon Research

International Society for Antiviral Research

European Academy of Dermatology and Venereology

*elected

 

HONORS

 

American Academy of Dermatology Presidental Citation (2016)

Alpha Omega Alpha Honor Medical Society

Joseph B. Kass Award for Research in Prevention of Disease (1982)

Medical Student Research Award (1983)

Mead Johnson Award for Excellence of Research by Intern-Resident (1984)

Roche Laboratory’s Award in Basic Sciences, Intern-Resident Division (1984)

Roche Laboratory’s Award in Basic Sciences, Intern-Resident Division (1985)

  1. Lewis Pipkin Award in Dermatology (1986)

Mead Johnson Award for Excellence of Research by Intern-Resident (1986)

Roche Laboratory Award for Excellence in Clinical Research, Intern-Resident Division (1986)

American Medical Association Award for Outstanding Clinical Research (1986)

Paul Anderson Memorial Research Award from Pacific Dermatology Association (1990)

Robert G. Freeman, M.D. Mentoring & Leadership Award for Outstanding Dedication and Contributions to Dermatology from Texas Dermatological Society (2014)

American Academy of Dermatology Presidental Citation (2016)

 

 

EDITORIAL BOARDS

 

  • Journal of the American Academy of Dermatology (Assistant Editor)
  • Journal of Cutaneous Medicine and Surgery
  • Skin Research and Technology
  • Skin Therapy Letter
  • Genital Herpes Management News
  • Dermatologic Therapy, guest editor
  • Dermatology Clinics of North America, guest editor
  • Revista de Ciencias Biologicas e da Saude
  • International Journal of Dermatology
  • Anais Brasileiros de Dermatologia

 

REVIEWER FOR THE FOLLOWING JOURNALS

 

  • Archives of Dermatological Research
  • Journal of Investigative Dermatology
  • Journal of the American Academy of Dermatology
  • Archives of Dermatology
  • Dermatologic Surgery
  • Photodermatology, Photoimmunology and Photomedicine
  • Journal of Cutaneous Medicine & Surgery
  • Skin Therapy Letter
  • Antiviral Research
  • Journal of Clinical Investigation
  • Annals of Internal Medicine
  • Journal of Infectious Diseases
  • American Journal of Medical Science
  • Journal of Molecular Medicine
  • Viral Immunology
  • Journal of Immunology
  • Southern Medical Journal
  • The Medical Letter
  • Journal of Medical Virology
  • Journal of Clinical Virology
  • Lancet
  • Obstetrics and Gynecology
  • AIDS Care
  • Journal of Antimicrobial Chemotherapy
  • Journal of the European Association of Dermatology and Venereology
  • New England Journal of Medicine
  • Journal of the American Medical Association

 

 

 

STUDY SECTION AND FEDERAL REVIEW COMMITTEES

 

  • National Institutes of Health Study Section: Epidemiology and Disease Control-2, 1991
  • Member of NIH site-visit committee for General Clinical Research Center 1994
  • NIAID review committee: Sexually Transmitted Diseases Cooperative Research Centers (STD-CRCS) 1995
  • NIAMSD Review Committee: RFA, AR-95-003, “Clinical Studies: Skin Diseases in HIV/AIDS”, 1996
  • Chairman, NIAID Special Emphasis Panel for RFA: Research on Topical Microbicides for Prevention of STDs/HIV 1999
  • Chairman, NIAID Special Emphasis Panel for RFA: Sexually Transmitted Diseases Cooperative Research Centers  2001
  • Member of NIH Study Section ZRG1 GMA-1 10B: Small Business, Dermatology 2003
  • Member of NIH Study Section ACTS (Arthritis, Connective Tissue and Skin) 2005

 

 

 

 

STATE AND NATIONAL COMMITTEES

 

  • American Academy of Dermatology Bioterrorism Task Force (2001-2004)
  • American Academy of Dermatology Committee on Sexually Transmitted Diseases (Chairman 1999-2008)
  • Board of Directors of American Cancer Society (Bay Area Unit)
  • Advisory Board Member of AIDS Alliance of Bay Area
  • STD Treatment Guidelines Committee of CDC AAD liaison, 1997-present
  • NIAID Liaison Committee Member for American Academy of Dermatology, 1998-2003
  • Scientific Advisory Committee of Dermatology Foundation, 1998-2000
  • Consultant to the National Aeronautics and Space Administration Medical Operations’ Astronaut Candidate Medical Selection and Standards Review Process, 1994-present
  • Scientific & Medical Advisor to the VZV Research Foundation

 

COMMUNITY ACTIVITIES

 

  • Advisory Board, AIDS Alliance of the Bay Area
  • Advisory Board, Center for AIDS (Houston)
  • Lecturer to various senior citizens groups on “Skin Problems of Senior Citizens”
  • Medical advisor to Houston Herpes “HELP” Chapter

 

 

INTERNATIONAL COMMITTEES

 

  • European Research Organization on Genital Infection and Neoplasia
  • Latvian Association of Dermatovenerologists
  • European Association of Dermatology and Venerology

 

COMMITTEE RESPONSIBILITIES

 

  • Executive Committee of the Faculty of Medicine (Member at Large) 1993 – 1994
  • Department of Dermatology Residency Selection Committee

 

TEACHING RESPONSIBILITIES

 

  • Lectures to Dermatology residents and students on Dermatology elective (UT, Baylor) (6-8 per year)
  • Weekly supervision and clinical teaching of dermatology residents and senior medical students (on elective) on the diagnosis and treatment of outpatients in the dermatology clinic
  • Seminars on current research given to the Departments of: Microbiology, Internal Medicine, Pediatrics, OB/Gyn, Family Medicine and Radiation Oncology (6-10 per year).

 

MEMBER ON SUPERVISORY COMMITTEES FOR GRADUATE STUDENTS

Afshan Anjum, M.S.

Mark Evers, M.D., M.S.

Deborah Payne, B.A., Ph.D.

James Patterson, B.A., M.D., Ph.D.

Wenjing Zhou, M.D., M.S.

Omeed Memar, M.D., Ph.D.

Elsa Haubold, B.A., Ph.D.

Hernan Sierra, B.A., Ph.D.

Nohelia Cajas, B.A., Ph.D.

Andrea Fuessel, M.S.

 

 

MENTOR TO POSTDOCTORAL FELLOWS

Franco Scinicariello, M.D.                     1989-1992

Robert Purvis, M.D.                                1990-1992

  1. Luke Lewis, M.D. 1991-1992

Ira Schlesinger, M.D.                             1992

Paul Rockley, M.D.                                 1992-1993

Richard Cirelli, M.D.                              1993-1995

Deborah Payne, Ph.D.                            1993-1995

Kathleen Herne, M.D.                            1994-1996

Monica McCrary, M.D.                           1995-1996

Martha Meeks, M.D.                               1995-1996

Komal Chopra, M.D.                               1996-1997

Angella Glidden, M.D.                            1996-1997

Zoltan Trizna, M.D., Ph.D.                     1996-1997

Tanya Evans, M.D.                                 1997-1999

Jessica Severson, M.D.                           1997-1999

William Whitehead, Ph.D.                     1999-2000

Concepcion Arrastia, M.D.                     1999-2001

(NIH WRHR Scholar)

Melody Vander Straten, M.D.               1999-2001

Daniel Carrasco, M.D.                            1999-2001

Trisha Brown, M.D.                                1999-2000

Ken Grattendick, Ph.D.                         1999-2001

Kimberly Yeung-Yue, M.D.                    2001-2002

Mathijs Brentjens, M.D.                         2001-2002

Karan Sra, M.D.                                      2002-2005

Gisela Torres, M.D.                                2002-2003

Jashin Wu, M.D.                                     2003-2004

Katie Pang, M.D.                                     2003-2004

Vandana Madkan, MD                           2005-2007

Julie Brantley, MD                                 2005-2006

Anita Arora, MD                                     2006-2007

Anne Marie Tremaine, MD                    2007-2008

Brenda Bartlett, MD                              2007-2009

Aron Gewirtzman, MD                           2007-2008

Parisa Ravanfar, MD                              2008-2009

Rosella Creed, MD                                  2008-2009

Anita Satyaprakash, MD                       2008-2009

Katie Morrison, MD                               2009-2010

Christopher Willison, MD                      2009-2010

George Magel, MD                                  2010-2011

Catherine DiGiorgio, MD                       2010-2011

Kassie Heitz, MD                                    2010-2011

Whitney LaPolla, MD                             2010-2012

Rana Mays, MD                                      2011-2012

Rachel Gordon, MD                                2011-2013

Marigdalia Ramirez-Fort, MD               2012-2013

Farhan Khan, MD                                  2012-2013

Aparna Tamirisa, MD                            2013-2014

Christopher Downing, MD                     2013-2015

Jacqueline Guidry, MD                          2014-2015

Sivaramya Kollipara, MD                      2014-2015

Michael Lee, MD                                    2014-2015

Zeena Nawas, MD                                  2015-2016

Lawrence Tong, MD                               2015-2016

Jared Peranteau, MD                             2015-2017

Kevin Sharghi, MD                                 2016-2017

Ramya Vangipuram, MD                       2016-present

 

 

 

MENTOR TO UNDERGRADUATE SUMMER RESEARCH STUDENTS

  1. Goel 1994

Stephanie Shaw                                      1997

Cynthia Chi                                             1997

John Rogers                                             1999

Michael Lu                                                  1999

Kimberly Au                                              1999

Vijay Mikkilineni                                       2001

Yu He                                                        2002

Matthew Huante                                           2007

Victoria Maldonado                                       2008

Alexa Li                                                     2009

Kathryn Camero                                        2009

Andres Sepulveda                                          2009

Harrison Nguyen                                           2010-present

Louie Rodriquez                                             2012

Anjali Patel                                                     2013

Julie Wu                                                          2014-present

Thomas Hsiao                                                 2015

Deepika Narayanan                                       2015-present

 

 

MENTOR TO MEDICAL STUDENTS AND DERMATOLOGY RESIDENTS

Stephanie Sim, M.D.

S-H. Chen, M.D.

Omeed Memar, M.D., Ph.D.

Joel Apisarnthanarax, M.D.

Pat Walsh, M.D., Ph.D.

Angela Yen, M.D.

Adam Kaspar, M.D.

Bruce Boyd, M.D., Ph.D.

Adam Czelusta, M.D.

Kevin Nagamani, M.D.

Lindsey Hicks, M.D.

Melissa Diamantis, M.D.

Kathryn Harmonson, M.D.

Jeffery Drucker, B.S.

Brandon Christianson, B.S.

Janice Wilson, M.D.

Amber Gill, M.D.

William Tausend, MD

Hung Doan, MD, PhD

 

 

 

MENTOR TO INTERNATIONAL MEDICAL STUDENTS AND PHYSICIANS

  1. Laghi (Italy) 1990
  2. Schowten (Netherlands) 1993-1994
  3. Van Vleuken (Netherlands) 1993-1994

Gen. I. Nedelcu, M.D., Ph.D. (Romania)           1994

  1. Rubins, M.D. (Latvia) 1998-1999
  2. Brewer, M.D. (Latvia) 1998-1999
  3. Albrecht, M.D. (Canada) 1999
  4. Lupi, MD, PhD (Brazil) 1999-2001
  5. Dianzani, M.D. (Italy) 1999-2000
  6. Roncalli, M.D. (Brazil) 2001-2002
  7. Mendoza, M.D. (Columbia) 2006-2015
  8. de Souza, MD (Brazil) 2010
  9. Cerci, MD (Brazil) 2010
  10. Pattanaprichakul, MD (Thailand) 2013-2014

 

 

MAJOR RESEARCH INTERESTS

 

  1. Role of specific viruses in sexually transmitted diseases: HPV, HIV, HSV, VZV
  2. Role of these viruses in the pathogenesis squamous cell carcinomas of the skin, cervix, ano-genital mucosa, and oral epithelia
  3. Association of human herpes 8 virus with specific human diseases
  4. Mechanism of action of cytokines and immunomodulatory agents as antiviral agents
  5. Impact of cytokines and immunomodulatory agents on oncogenes and suppressor genes
  6. Evaluation and testing of new antiviral and antitumor agents in clinical trials
  7. Evaluation and testing of new antiviral vaccines: HPV, HIV, HSV, VZV

 

 

FEDERAL GRANTS

 

  1. NIAID and Collaborative Antiviral Study Group (CASG): “Acyclovir with and without Prednisone for the Treatment of Herpes Zoster.  A Randomized, Placebo-Controlled Trial” 1984-1994.

 

  1. NIAID: “Treatment of Condyloma Acuminatum with Three Different Interferons Administered Intralesionally:  A Multicentered, Placebo-Controlled Trial” 1985-l986.

 

  1. NIAID: “Treatment of Condyloma Acuminatum with Three Different Alpha Interferon Preparations Administered Parenterally:  A Double Blind, Placebo-Controlled Trial”.  1986-1987.

 

  1. NIAID: Grant No. 1RO1 AI26896-01A1: “Mechanisms of Interferon Action Against Papillomaviruses.” 1989-1993. Principal Investigator    $1,800,000

 

  1. NIAID: Grant AI-62554:  “Evaluation of SQ32, 756 (BV-ARA-U) Versus Acyclovir in the Treatment of Localized Herpes Zoster in Immunocompromised Patients (-37)” 1991-1995.

 

  1. NIAID: Grant AI-62554:  “Evaluation of SQ32, 756 (BV-ARA-U) Versus Acyclovir in the Treatment of Localized Herpes Zoster in HIV-Infected Patients (-38/-022)” 1991-1996.

 

  1. NASA: “Incidence of Latent Virus Shedding During Space Flight” 1995-2002.

 

  1. Centers for Disease Control: “Pilot Surveillance for Acyclovir Resistant Herpes Simplex Virus” 1997-1998.

 

  1. NIH: UTMB WRHR Career Development Center of Excellence (Mentor and participator training site) 1998-2003.

 

  1. NIAID: “Polymorphism of the Herpes Simplex Virus Receptor” 1998-2008.

 

  1. NIAID: Use of the Polymerase Chain Reaction to Diagnose Varicella-Zoster Virus Infections and to Monitor Anti-Viral Therapy” 1999- 2002.

 

  1. NIAID: “Dynamics of Interleukin 10 in Neuroimmune Interactions”:  Co-Investigator, 2000-2005.

 

  1. NINDS: “Analgesia in Herpes Zoster and Postherpetic Neuralgia”:  Consortium Principal Investigator (R21 grant), 2001-2007.

 

  1. NIH, NIAID, DMID and GlaxoSmithKline: “A Double-blind, Randomized, Controlled Phase III Study to Assess the Prophylactic Efficacy and Safety of gD-Alum/MPL Vaccine in the Prevention of Genital Herpes Disease in Young Women who are HSV- and -2 Seronegative” Sub-investigator, 2003-2010.

 

  1. NCI: “Genetic Resistance to Oncogenic Human Papillomaviruses” (RO3CA030730) Principal Investigator, 2003-2006.

 

 

  1. NIAID: “Molecular Basis of Infectious Disease” (1 T32 AI055449-01A2; PI: S. Norris) Co-Investigator (i.e. Mentor), 2005-2015.

 

  1. NIH: “The effect of HPV on apoptosis and cellular proliferation.” (K08 DC010337-01A2; PI: M. Underbrink)  Co-Investigator (i.e. Mentor), 2011 – 2016.

 

 

  1. NIH: “A trial to determine the effect of psoriasis treatment on cardiometabolic disease”  (1-R01-HL-111293 to University of Pennsylvania ORS Institution #  10031364; PI:  Gelfand) Co-Investigator, 2014- present

 

 

INTRAMURAL AND FOUNDATION GRANTS

 

  1. UTMB “Investigation of Combination Therapies with Polyribonucleotides and Immunomodulatory Agents Using Shope Papillomavirus-induced Carcinomas in Rabbits” 1987-1988.

 

  1. Dystrophic Epidermolysis Bullosa Research Association (DEBRA): “An Evaluation of Cell Mediated Immunity in Persons with Inherited Forms of Epidermolysis Bullosa” 1987-1988.

 

  1. March of Dimes Birth Defect Foundation: “An Evaluation of Histocompatibility Antigens (HLA) in Patients with Inherited Forms of Epidermolysis Bullosa” 1989-1991.

 

  1. Sealy Foundation Grant: “Genetic Susceptibility to Cutaneous Malignancy in Inherited Forms of Epidermolysis Bullosa” 1991-1993.

 

  1. Yamanouchi USA Foundation: “Clinical Development of Anti-Herpes Drugs” 2001-2002.

 

  1. Sealy Center for Environmental Health and Medicine: “Interaction of Risk Factors for Cervical Cancer”:  Principal Investigator.  2001-2002.

 

 

 

 

 

OTHER SPONSORED GRANTS (PRINCIPAL INVESTIGATOR)

 

  1. Schering Corporation: “Treatment of Giant Condyloma Acuminatum with Intralesional Interferon Alpha” 1986-1987.

 

  1. Biogen Corporation: “A Double-Blind Placebo Controlled Study of the Safety and Efficacy of Two Regimens of Recombinant Interferon Gamma (rIFNg) in the Treatment of Condyloma Acuminatum” 1988-1990.

 

  1. Schering Corporation: “Prevention of Transfusion-associated non-A, non-B Hepatitis by Interferon” 1988-1991.

 

  1. Schering Corporation: “The Effect of SCH 30500 on Squamous Cell Carcinoma” 1989-1990.

 

  1. SmithKline Beecham Pharmaceuticals: “A Double-Blind, Randomized Placebo-Controlled Parallel Group Study to Assess the Safety and Efficacy of Oral BRL42810 in the Treatment of Patients with Uncomplicated Herpes Zoster, Protocol 008” 1990-1992.

 

  1. SmithKline Beecham Pharmaceuticals: “Treatment of First Episode Genital Herpes with Famciclovir, an Acyclovir Controlled Trial, Protocol 040” 1991-1993.

 

  1. SmithKline Beecham Pharmaceuticals: “Open, Non-Randomized, Dose-Escalation of Evaluation of the Efficacy and Safety of BRL 39123A in the Treatment of Mucocutaneous Herpes Simplex Infection in Immunocompromised Patients” 1991-1993.

 

  1. Burroughs Wellcome Co.: “A Multicenter, Double-Blind, Controlled Trial Comparing Oral Acyclovir to Oral 256U87 for the Treatment of Herpes Zoster in Immunocompetent Patients 50 years of Age and Older, Protocol 05” 1991-1992.

 

  1. Burroughs Wellcome Co.: “A Multicenter Double-Blind, Placebo-Controlled Trial Evaluating 256U87 for the Treatment of Herpes Zoster in Immunocompetent Patients Less than 50 Years of Age, Protocol 06” 1991-1992.

 

  1. Burroughs Wellcome Co.: “A Study of Investigate the Efficacy and Safety of Orally Administered 256U87 in the Treatment of Recurrent Genital Herpes in Immunocompetent Patients, Protocol 04” 1991-1992.

 

  1. Burroughs Wellcome Co.: “A Study to Investigate the Efficacy and Safety of 256U87 Versus Acyclovir in the Treatment of Recurrent Ano-Genital Herpes Infection in HIV Infected Patients, Protocol 08” 1991-1992.

 

  1. Burroughs Wellcome Co.: “Comparative Trial of 256U87 and Acyclovir for the Suppression of Recurrent Anogenital Herpes Infections in HIV Infected Patients, Protocol 66-07” 1991-1995.

 

  1. Burroughs Wellcome Co.: “A Comparative Trial of 256U87 and Acyclovir for the Treatment of First-Episode Genital Herpes Infection” 1992-1993.

 

  1. Schering Corporation: “Treatment of Genital Herpes with Intralesional Interferon Alpha” 1991-1992.

 

  1. Schering Corporation: “Treatment of Tinea Pedis with 1% Clotrimazole Cream” 1992-1993.

 

  1. Schering Corporation: “Treatment of keloids with Intralesional Interferon Alpha” 1992-1993.

 

  1. Hoffmann La Roche: “Treatment of Condyloma Acuminatum with Intralesional Interferon Alpha (Roferon™)” 1992-1993.

 

  1. Matrix Pharmaceuticals, Inc.: MP#17-91-P  “A Randomized, Double-Blind Controlled Study to Evaluate the Contributions of Components in the Therapeutic Implant 5-FU-3 TI 5003 when Administered to Patients with External Condylomata Acuminata” 1992-1993.

 

  1. Oclassen Pharmaceuticals: “A Double-Blind Placebo Controlled Study in the Safety and Efficacy of 0.5% Podofilox Gel in the Treatment of External Genital Warts” 1992-1993.

 

  1. Burroughs Wellcome Co.: “A Study to Investigate the Efficacy and Safety of Oral Valacyclovir (1000mg or 500mg, twice daily) Compared with Placebo in the Treatment of Recurrent Genital Herpes in Immunocompetent Patients, Protocol 028” 1992-1993.

 

  1. 3M Pharmaceuticals: IMIQ-1005-06. “Vehicle-Controlled Safety and Efficacy Trial Evaluating Daily Overnight Application of 1% and 5% Imiquimod Cream for the Treatment of Genital/Cervical Warts” 1992-1993.

 

  1. ISIS Pharmaceuticals: “A Randomized, Double-Blind, MultiInvestigator Clinical Evaluation of Comparing Two Single Dose Levels of ISIS 2105 with Vehicle Control for Therapy in Condyloma Acuminatum Patients” 1992-1993.

 

  1. SmithKline Beecham Pharmaceuticals: “A Double-Blind, Randomized Placebo-Controlled Study to Assess the Efficacy and Safety of Oral Famciclovir in the Suppression of Recurrent Genital Herpes Infection in Women, Protocol 024” 1992-1993.

 

  1. Burroughs Wellcome Co.: A Placebo-Controlled evaluation of Acyclovir 348U87 Cream for the Treatment of Herpes Simplex Labialis Infection. Protocol P-120-008″ 1993-1994.

 

  1. SmithKline Beecham Pharmaceuticals: “A Prospective, Randomized, Double-Blind, Multicenter, Patient-Initiated Study to Compare the Efficacy of Topical 1% Penciclovir Cream with Placebo in Patients with Recurrent Herpes Simplex Labialis Infection ” 1993-1994.

 

  1. Burroughs Wellcome Co.: “A Comparative Trials of Valacyclovir with Acyclovir for the Suppression of Genital Herpes Infections in Immunocompetent Patients, Protocol 026” 1994-1995.

 

  1. SmithKline Beecham Pharmaceuticals: “Double Blind, Double-Dummy, Randomized, Placebo-Controlled Study to Assess the Safety of Oral Famciclovir for the Suppression of Recurrent Genital Herpes Infection, Protocol 033” 1994-1995.

 

  1. ISIS Pharmaceuticals: “Pilot Randomized, Multiple-Dose Study of Afovirsen Sodium for Surgical Adjunctive Therapy of external Condyloma Acuminatum” 1994-1995.

 

  1. Bristol Myers Squibb: “Double-Blind Multinational Trial Comparing Sorivudine [BV-ARA-U] (SQ32, 756) Versus Acyclovir for the Treatment of Acute Localized Zoster and the Effect on Zoster-Associated Pain in Immunocompetent Subjects” 1994-1996.

 

  1. Gilead Sciences: “Phase I/II Study of the Safety and Efficacy of Topical 1-(s)-(3-Hydroxy-2-phosphonyl-methoxypropyl) Cytosine Dihydrate (HPMPC) in the Treatment of Condyloma Acuminatum in Patients with HIV infection” 1994-1997.

 

  1. Pfizer Pharmaceutical: “Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Safety and Efficacy Study of Tioconazole 20% in the Treatment of Distal Subungual Onychomycosis of the Toenail” 1994-1995.

 

  1. Burroughs Wellcome Co.: “A Randomized Controlled Study of Acyclovir versus Netivudine for Treatment of Herpes Zoster, Protocol 011” 1994-1996.

 

  1. Collaborative Study with University of Indiana: “Attitudes Regarding Herpes Vaccination” 1994-1995. Collaborative Study with St. Louis University School of Medicine: Comparison of Direct Fluorescent Antigen with Polymerase Chain Reaction for Diagnosis of Varicella Zoster Virus Infections” 1994-1998.

 

  1. Collaborative Study with St. Louis University School of Medicine: Comparison of Direct Fluorescent Antigen with Polymerase Chain Reaction for Diagnosis of Varicella Zoster Virus Infections” 1994-1998.

 

  1. Collaborative Study with University of Washington: “Studies of Asymptomatic Viral Shedding in Persons with Recurrent Genital Herpes” 1994-1998.

 

  1. Glaxo Wellcome: “A Double Blind, Multicenter Study Comparing Valacyclovir with Famciclovir for the Treatment of Uncomplicated Herpes Zoster in Immunocompetent Patients 50 Years of Age and Older” 1994-1997.

 

  1. Bristol Myers Squibb: “An Open, Multicenter Study to Determine the Effect of Sorivudine on Dihydropyrimidine Dehydrogenase Activity in Peripheral Blood Mononuclear Cells of Patients with Acute Herpes Zoster” 1995-1996.

 

  1. Lidak Pharmaceuticals: “A Clinic Initiated, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy of Topical n-Docosanol 10% Cream (LIDAKOLTM) in Patients with Early-Stage Episodes of Acute, Recurrent Herpes Labialis” 1995-1996.

 

  1. SmithKline Beecham Pharmaceuticals: “A Double-Masked, Double-Dummy, Randomized, Acyclovir-Controlled, Parallel Group Study to Compare the Efficacy and Safety of Famciclovir with Acyclovir in the Treatment of Patients with Ophthalmic Zoster” 1995-1997.

 

  1. SmithKline Beecham Pharmaceuticals: “A Randomized, Double-Blind, Double-Dummy, Multicenter Acyclovir-Controlled Study to Assess the Safety and Efficacy of Oral Famciclovir for the Treatment of Herpes Zoster Infection in Immunocompromised Patients, Protocol 086” 1995-1997.

 

  1. Astra Pharmaceuticals: “An Open Label Study to Evaluate the Effects of Chemical and Mechanical Methods of Skin Preparation Prior to Application of EMLA Cream on the Absorption of Lidocaine and Prilocaine and on the Effectiveness of EMLA Cream” 1996-1997.

 

  1. Glaxo Wellcome, Inc.: “A Comparison of Oral Valtrex 500mg Twice Daily for Three or Five Days for Treatment of Recurrent Genital Herpes” 1996-1997.

 

  1. 3M Pharmaceuticals: “Open-Label Trial Evaluating the Percutaneous Penetration of Imiquimod 5% Cream (Formulation U-2e) Following Overnight Application Three-Times Per Week for the Treatment of Genital/Perianal Warts” 1996-1997.

 

  1. 3M Pharmaceuticals: “Vehicle-Controlled Study Investigating the Mechanism of Action of 5% Imiquimod Cream Applied Three Times a Week for the Treatment of Patients with Genital/Perianal Warts” 1996-1997.

 

  1. SmithKline Beecham Biologicals: “An Open-Label Study to Evaluate Famciclovir in the Management of Acute Uncomplicated Herpes Zoster in Persons Infected with HIV” 1996-1997.

 

  1. Bristol Myers Squibb: “A Randomized Double Blind, Placebo-Controlled Efficacy and Safety Study of Oral Lobucavir in Patients with Recurrent Herpes Labialis, Protocol 012” 1997-1998.

 

  1. Bristol Myers Squibb: “A Randomized, Double Blind, Placebo-Controlled Efficacy and Safety Study of Oral Lobucavir in Patients with Recurrent Genital Herpes, Protocol 011” 1997-1998.

 

  1. Gilead Sciences: “A Double Blind, Placebo-Controlled Study of the Safety and Efficacy of Cidofovir Gel for the Treatment of Molluscum Contagiosum in Patients with HIV Infection” 1997-1998.

 

  1. SmithKline Beecham Biologicals: “A Randomized, Double-Blind, Double-Dummy Study to Assess the Efficacy and Safety of Oral Famciclovir Compared to Oral Valacyclovir for the Suppression of Recurrent Genital Herpes, Protocol 210” 1997-1999.

 

  1. SmithKline Beecham Biologicals: “A Double-Blind, Randomized, Parallel Group, Multi-Center Study, to Compare the Safety and Efficacy of 10 Days of Oral Famciclovir 750 mg Three Times a day with Oral Valacyclovir 1 g Twice a Day in Reducing the Frequency of Subsequent Lesional Recurrences of HSV-2 in Patients Following Treatment of First Episode Genital HSV-2, Protocol 191” 1997-1998.

 

  1. Pentose: “A Phase I/II Dose-Ranging Study of the Safety and Efficacy of PEN203 in the Treatment of Common Warts” 1998-1999.

 

  1. Pentose: “A Phase I/II Dose-Ranging Study of the Safety and Efficacy of PEN203 in the Treatment of Genital Warts” 1998-1999.

 

  1. Glaxo Wellcome, Inc.: “Herpes Advice Consortium (Herpes Questionnaire)” 1998.

 

  1. Abbott Laboratories: “The Safety and Efficacy of Three Doses of ABT-606 Compared to Acyclovir in the Treatment of Herpes Zoster in Immunocompetent Adults” 1998-1999.

 

  1. Bristol Myers Squibb: “A Randomized, Double-Blind, Placebo-Controlled Trial, Genital Herpes Oral Suppression Trial (GHOST) of Oral Lobucavir, Protocol 043” 1998-1999.

 

  1. Glaxo Wellcome, Inc.: “A Randomized, Double-Blind, Placebo-Controlled Evaluation of Valaciclovir for the Prevention of Herpes Simplex Virus Transmission in Heterosexual Couples” 1997-2002.

 

  1. Glaxo Wellcome, Inc.: “An Open-Label Study of Valacyclovir HCl 1.5 grams bid for Treatment of Uncomplicated Herpes Zoster in Immunocompetent Patients 18 years of Age and Older” 1997-2001.

 

  1. Glaxo Wellcome, Inc.: “A Double-Blind Study Comparing Two Doses of Valacyclovir HCl for the Treatment of Uncomplicated Herpes Zoster in Immunocompromised Patients 18 Years of Age and Older” 1997-2006.

 

  1. 3M Pharmaceuticals: “Safety and Efficacy Trial Evaluating 5% Imiquimod Cream Application to External Genital Warts and an Extended Treatment Area” 1998-2001.

 

  1. 3M Pharmaceuticals: “A Phase II, Randomized, Double-Blind, Vehicle-Controlled, Dose-Escalating Study to Assess Safety and Preliminary Efficacy of Topical R-848 gel in the Treatment of Recurrent Herpes Genitalis” 1998-2000.

 

  1. 3M Pharmaceuticals: “A Mechanism of Action Study of Aldara (Imiquimod) Cream 5% Applied Topically to Patients with Superficial Basal Cell Carcinoma” 1998-2000.

 

  1. Schering-Plough Corporation: “A Phase II Proof of Principle Study Comparing Two Doses of Interleukin 10 (TENOVIL) Administered Subcutaneously to Placebo in Severe Psoriasis” 1999-2000.

 

  1. Corixa Corporation: “A Multi-Center, Randomized, Controlled Phase II Study Evaluating the Effect of PVAC Treatment in Patients with Psoriasis, Protocol CCPV001-04” 1999-2001.

 

  1. Glaxo Wellcome, Inc.: “A Multicenter, Double-Blind, Placebo-Controlled Evaluation of Valaciclovir for the Prevention/Blockage of the Progression of Cold Sore Lesion Development, Protocol HS230028” 1999-2002.

 

  1. Corixa Corporation: “A Multi-Center, Open-Label Study Evaluating the Effect of PVAC Treatment in Patients with Psoriasis who have been Previously Treated with PVAC or Control, Protocol CCPV001-05” 2000-2002.

 

  1. Quidel Corporation: “HSV Antibody Test CS-0105-3” 2000.

 

  1. Genentech: “A Phase III, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter, Multidose Study to Evaluate the Efficacy and Safety of Subcutaneously Administered Anti-CD11a in Adults with Moderate to Severe Plaque Psoriasis Who are Candidates for Systemic Therapy” 2000-2002.

 

  1. 3M Pharmaceuticals: A Phase III, Vehicle-Controlled Study of Topical R-848 0.01% Gel Applied 2 Times per Week for 3 Weeks for Each Recurrence of Herpes Genitalis over 12 Months to Prevent Subsequent Recurrences, Protocol 1404-RESI” 2000-2004.

 

  1. Merck & Co., Inc.: “A Study to Evaluate the Cell-Mediated Immune Responses of Herpes Zoster Patients Compared to Healthy Subjects Over a Six-Month Period” 2000-2002.

 

  1. Harvard University School of Medicine: “Efficacy of Riluzole in the Prevention of Postherpetic Neuralgia” 2001-2002.

 

  1. GlaxoSmithKline: “A Multicenter, Double-Blind, Placebo-Controlled Trial to Evaluate Daily Suppressive Therapy with Valtrex on the Rate of HSV Shedding in Patients with Recurrent Genital Herpes” 2001-2002.

 

  1. 3M Pharmaceutical: “Resiquimod (R-848) 0.01% gel (U-1j) for the Treatment of Herpes Genitalis to Prevent Recurrences, Protocol 1419-RESI” 2001- 2003.

 

  1. Quidel Corporation: “Quick-Vue Herpes Simplex Antibody Test Clinical Trial Part 2” 2002.

 

  1. GlaxoSmithKline: “A Randomized, Double-Blind, Multicenter Study of Valtrex 500 mg Suppressive Therapy in the Reduction of Anxiety Associated with Recurrent Genital Herpes, Protocol HS240021” 2002.

 

  1. Corixa Corporation: “A Multi-center, Randomized, Placebo-Controlled Phase 2 Study Evaluating the Effect of 15mg PVAC Treatment in Patients with Psoriasis, Protocol CCPV001-06” 2002-2003.

 

  1. Genentech: “A Phase IIB, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of 1.0 mg/kg Subcutaneously Administered Efalizumab in Adults with Moderate to Severe Plaque Psoriasis, Protocol ACD2390g” 2002-2003.

 

  1. Genentech: “An Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of 1.0 mg/kg Subcutaneously Administered Efalizumab Followed by Efalizumab Taper in Adults with Plaque Psoriasis Previously Enrolled in Study ACD2391g” 2002-2003.

 

  1. GlaxoSmithKline: “An Open-label Pilot Study of Valtrex 2g for One Day in the Episodic Treatment of Recurrent Genital Herpes, Protocol R-94” 2002-2003.

 

  1. Merck & Co., Inc.: “Protocol for Obtaining Clnical Specimens to Support Validation of a Polymerase Chain Reaction and a Direct Fluorescent Antibody Assay for Detection of Varicella-Zoster Virus, Protocol 008-00” 2002-2003.

 

  1. 3M Pharmaceuticals: “A Study of Local Immunologic Effects of Resiquimod 0.01% Gel Applied Topically to Herpes Lesions of Subjects with Recurrent Herpes Genitalis, Protocol 1438-RESI” 2002-2004.

 

  1. Immunex/Amgen: “A Phase III, Multicenter Study of the Safety and Efficacy of Enbrel (etanercept) in Psoriasis, Protocol 16.0042” 2002-2003.

 

  1. GlaxoSmithKline: “Reduction of postherpetic neuralgia in herpes zoster” 2002-2008.

 

  1. Amgen: “An Open-Label, Long-Term Extension Study to Assess the Safety of Etanercept in the Treatment of Psoriasis in Adult Subjects, Protocol 115” 2003-2005.

 

  1. Amgen: “A Phase 3 Multicenter Study to Assess the Efficacy and Safety of Etanercept 50mg Twice Weekly in Psoriasis, Protocol 117” 2003-2007.

 

  1. Amgen: “A Multicenter, Open Label Study to Observe the Effect of Etanercept on Joint and Skin Disease in Subjects with Psoriatic Arthritis, Protocol 2003106” 2003-2005.

 

  1. GlaxoSmithKline: “An Open-Label Study to Describe the Pharmacokinetics of Topical Applications Twice Daily for Five Days, of SB275833, 1% Ointment, and to Assess Preliminary Safety and Efficacy in the Treatment of Subjects with Uncomplicated Bacterial Skin Infections” 2003.

 

  1. GlaxoSmithKline: “A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Assess the Safety and Efficacy of GW406381 25 mg and 50 mg, Administered Once Daily for 21 Days to Subjects with Postherpetic Neuralgia, Protocol CXA20009” 2003-2005.

 

  1. Novartis: “A Six Month Open Label, Randomized Multi-Center study to Evalute the Comparative Efficacy and Safety of Oral Famvir (famciclovir) in the Episodic (125 mg bid for 5 days) and Suppressive Treatment (250 mg bid) or Recurrent Genital Herpes, Protocol CFAM810A US07” 2003-2005.

 

  1. Novartis: “A Randomized Multicenter, Double-Blinded Controlled Study to Compare the Effectiveness of a Single Dose (1500 mg) of Famciclovir, One Day (750 mg Q12) of Famciclovir and Placebo in Patient-Initiated Episodic Treatment of Recurrent Herpes Labialis, Protocol CFAM810A2403” 2003-2005.

 

  1. Novartis: “A 26-week, Randomized, Multicenter, Parallel-group, Double-blind, Vehicle-controlled Study to Evaluate the Incidence of Atopic Dermatitis Flares When ASM981       ( pimecrolimus) Cream is Used at the First Signs and/or Symptoms of Atopic Dermatitis and Its Safety and Tolerability in Adults 18 Years of Age and Older, Protocol CASM981C2316” 2003-2005.

 

  1. Novartis: “A 6-week randomized, multicenter, double-blind, placebo-controlled, parallel group study to investigate the efficacy and safety of Elidel Cream 1% in patients with mild to moderate chronic hand dermatitis, followed by a 6-week open label phase to assess the safety of Elidel Cream 1%” 2004.

 

  1. XenoPort: “A multicenter, randomized, double-blind, placebo-controlled study assessing the safety and efficacy of XP13512 in patients with post-herpetic neuralgia (PHN)” 2004-2005.

 

  1. Serono: “A multicentre, randomized, double blind, placebo controlled phase III study of subcutaneously administered onercept in the treatment and re-treatment of subjects with moderate to severe plaque psoriasis” 2004-2005.

 

  1. Pfizer: “A double-blind, randomized, placebo-controlled trial of the time to onset of meaningful pain relief in subjects with postherpetic neuralgia (PHN) treated with pregabalin 150-600mg/day flexible optimized dose or 300mg/day fixed dose or placebo” 2004-2005.

 

  1. GlaxoSmithKline: “Two identical double-blind, double-dummy, multicenter, comparative phase III studies of the safety and efficacy of topical 1% SB-275833, applied twice daily, versus oral cephalexin, 500mg in adults, or 12.5 mg/kg (250mg/5ml) in children, twice daily, in the treatment of uncomplicated secondarily infected traumatic lesions” 2004-2005.

 

  1. Novartis: “Randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of a patient initiated 1-day treatment with famciclovir 1000mg b.i.d. for recurrent genital herpes infection in immunocompetent patients”, Protocol CFAM810A2402; 2003-2005.

 

  1. Medicis: “A Randomized, Double-Blind, Placebo-Controlled Phase III Study of an Extended-Release Formulation of Minocycline for the Treatment of the Inflammatory Lesions of Acne Vulgaris”, Protocol MP-0104-05; 2004-2005.

 

  1. Medicis: “An Open-Label Safety Study of a New Formulation of Minocycline for Treatment of Moderate to Severe Acne”, Protocol MP-0104-07; 2005.

 

  1. GlaxoSmithKline: “An international, randomized, double-blind, placebo-controlled, multicenter, 6-month study of the efficacy and safety of valacyclovir 1g once daily vs. placebo for the suppression of HSV-2 genital herpes in newly infected immunocompetent subjects” Protocol HS2100275; 2004-2006.

 

  1. GlaxoSmithKline: “A randomized, double-blind, placebo-controlled, multicenter 60 day study comparing the efficacy of Valtrex 1 gram once daily vs. placebo once daily in reducing viral shedding in immunocompetent subjects with recurrent HSV-2 genital herpes” Protocol HS2100273; 2004-2005.

 

  1. Fujisawa: “A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Once Daily 0.3% Tacrolimus Gel Versus Gel Vehicle in the Treatment of Psoriasis” Protocol 03-0-169; 2004-2005.

 

  1. Amgen: “A Multicenter, Open-label, Prospective Study to Evaluate the Effectiveness and Safety of Etanercept in the Treatment of Subjects with Psoriasis” Protocol 20040190; 2004-2005.

 

  1. GlaxoSmithKline: “A randomized, double-blind, placebo-controlled, two-way crossover study evaluating the efficacy of once daily valacyclovir in reducing viral shedding in HSV-2 seropositive subjects with no previous history of symptomatic genital herpes infection” Protocol VLX103596; 2005-2006.

 

  1. Corgentech: “A phase 1/2 multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study to evaluate the safety of repeated topical application of three concentrations of NF-kappaB decoy in adults with mild-to-moderate atopic dermatitis” Protocol 110-01P; 2005-2006.

 

  1. Abbott: “A phase 3, multicenter study of the efficacy and safety of long-term adalimumab treatment in subjects with moderate to severe chronic plaque psoriasis” Protocol MO3-656; 2005-2006.

 

  1. Leo Pharma: “Calcipotriene plus betamethasone dipropionate gel compared to the gel vehicle in scalp psoriasis, in patients receiving calcipotriene plus betamethasone dipropionate ointment for psoriasis vulgaris of trunk/limbs” Protocol 0502 US; 2005-2007.

 

  1. Abbott: “A multicenter open-label continuation study in moderate to severe chronic plaque psoriasis subjects who completed a preceding psoriasis clinical study with adalimumab” Protocol M03-658; 2006-2009.

 

  1. Abbott: “A phase 2, multicenter, randomized, double-blind, placebo-controlled study comparing the safety and efficacy of subcutaneous injections of ABT-874 vs. placebo in subjects with moderate to severe chronic plaque psoriasis” Protocol M05-736; 2006-2009.

 

  1. Astellas: “A phase 3, randomized, double-blind study to evaluate the efficacy and safety of BID application of tacrolimus cream-B 0.1% versus cream-B vehicle in the treatment of psoriasis” Protocol 04-0-206; 2006-2007.

 

  1. Novartis: “A multicenter, randomized, double-blind study to compare the efficacy and safety of patient-initiated famciclovir 1000mg b.i.d. X 1 day to valacyclovir 500mg b.i.d. X 3 days in immunocompetent adults with recurrent genital herpes”; Protocol CFAM810A2308; 2006-2008.

 

  1. Janus Pharma: “A phase II, multi-center, placebo controlled, safety, efficacy and absorption evaluation of ARYS-01 (sorvirudine) cream, 3% in herpes zoster patients” Protocol ARYS-0502; 2006-2007.

 

  1. Galderma: “A multi-center, randomized, double-blind, parallel-group study to demonstrate the efficacy and safety of adapalene/benzoyl peroxide topical gel compared with adapalene topical gel, 0.1% benzoyl peroxide topical gel, 2.5% and topical gel vehicle in subjects with acne vulgaris” Protocol RD.06. SPR.18087; 2006-2007.

 

  1. Medivir: “A randomized, double-blind, active-controlled, vehicle-controlled, subject initiated study comparing efficacy and safety of ME-609 versus acyclovir cream for recurrent herpes simplex labialis” Protocol 609-04; 2006-2008.

 

  1. Amgen, Inc.: “Observational Post-Marketing Safety Surveillance Registry of Enbrel (etanercept) for the Treatment of Psoriasis” Protocol 20040210; 2006-2009.

 

  1. Galderma: “Pharmacokinetics and Pharmacodynamics of Calcitriol Following Twice Daily Application of Calcitriol 3µg/g Ointment under Conditions of Maximal Use in Adolescents with Plaque Psoriasis” Protocol Number:RD.06.SPR.18102; 2006-2009.

 

  1. Dow Pharmaceutical Sciences, Inc.: “A Multi-center, Randomized, Double-Blind, Parallel-Group Study to Demonstrate the Efficacy and Safety of Adapalene Lotion, 0.1% Compared with Vehicle Lotion in Subjects with Acne Vulgaris” Protocol RD.06.SPR.18113; 2007-2008.

 

  1. PLIVA Research & Development Ltd: “A Randomized, Double-Blind, Multiple-site, Placebo Controlled, Parallel Design, Clinical Study to Evaluate the Bioequivalence of Adapalene Gel 0.1% (PLIVA Research & Development Ltd.) Compared to Differin (adapalene 0.1%) Topical Gel (Galderma Laboratories) in Patients with Acne Vulgaris” Protocol 70716202; 2007-2008.

 

  1. Glenmark Pharmaceuticals, Inc.: “A Randomized, Double-Blind, Placebo Controlled, Parallel Design, Multi-Site Clinical Study to Evaluate the Bioequivalence of Calcipotriene OIntment 0.005% (Glenmark Pharmaceuticals) to DOVONEX (calcipotriene ointment) 0.005% (Bristol Myers Squibb) in Patients with Moderate to Severe Plaque Psoriasis” Protocol GLK602; 2007-2008.

 

  1. BioAlliance Pharma SA: “A Randomised, Double-Blind, Single-dose, One-Day Early Administration, Multicentre Study comparing the Efficacy and Safety of Acyclovir Lauriad 50 mg muco-adhesive buccal tablet to matching Placebo, in the Treatment of Herpes Labialis in Immunocompetent Patients” LIP Study (Lauriad  Immunocompetent Patients Study)” Protocol BA2005/21/02; 2007-2009.

 

  1. Astellas Pharma: “A Phase II Dose-Finding Study with ASP2151 in Subjects with Recurrent Episodes of Genital Herpes” Protocol 15L-CL-101; 2007-2009.

 

  1. Gilead Sciences, Inc.: “A Phase I, Randomized, Double-blind, Placebo-controlled Assessment of the Safety, Tolerability, and Activity of GS-9191 Ointment for the Treatment of External Genital and Perianal Warts Caused by Human Papilloma Virus Infection” Protocol GS-197-0101; 2007-2009.

 

  1. Epiphany Biosciences, Inc.: “A randomized, double-blind, active-controlled, multi-center, parallel-group dose-ranging study assessing the safety and efficacy of EPB-348 versus valacyclovir among immunocompetent patients with an acute episode of herpes zoster” Protocol EPB348-0201; 2007-2010.

 

  1. Hoffman-LaRoche: “A randomized, double-blind, placebo-controlled dose-ranging study to assess the safety, tolerability, pharmacokinetics and to explore the effect on clinical response and pharmacodynamics of RO5092888 in patients with moderate to severe chronic plaque psoriasis”  Protocol No. NS20454; 2007-2009.

 

  1. Abbott Laboratories: “A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects with Moderate to Severe Chronic Plaque Psoriasis” Protocol M06-890; 2007-2009.

 

  1. Abbott Laboratories: “A Phase 3, Multicenter, Open-label Continuation Study in Moderate to Severe Chronic Plaque Psoriasis Subjects who Completed a Preceding Psoriasis Study With ABT-874” Protocol M10-016; 2008-2010.

 

  1. Abbott Laboratories: “A Phase 3, Multi-center, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects with Moderate to Severe chronic Plaque Psoriasis” Protocol M10-114, 2008-2009.

 

  1. Abbott Laboratories: “Open-label Study of Adalimumab in Subjects Who Have a Sub-optimal Response to Systemic Therapy or Phototherapy” Protocol M10-238; 2008-2009.

 

  1. Abbott Laboratories: “A Phase 3, Multi-center, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects with Moderate to Severe Chronic Plaque Psoriasis” Protocol M10-315, 2008-2009.

 

  1. Abbott Laboratories: “A Controlled Study of HUMIRA in Subjects with Chronic Plaque Psoriasis of the Hands and/or Fee,t” Protocol M10-405; 2008-2010.

 

  1. Amgen, Inc.: “A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Etanercept in Treating Scalp Involvement in subjects with Moderate to Severe Plaque Psoriasis,” Protocol 20080014; 2008-2009.

 

  1. aRigen Pharmaceuticals, Inc.: “Phase II/III Multicenter, Double-Blind, Controlled Trial Comparing topical ARYS-01 Cream (3% Sorivudine), Oral Valaciclovir, and combination Topical ARYS-01 Cream/Oral Valaciclovir for the Treatment of Herpes Zoster in Immunocompetent Patients 18 Years of Age or Older” Protocol ARYS-0701; 2008-2009.

 

  1. Galderma: “Efficacy and Safety comparison of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel associated with Doxycycline Hyclate 100 mg Tablets versus Adapalene 0.1% / Benzoyl Peroxide 2.5% Vehicle Gel associated with Doxycycline Hyclate 100 mg Tablets in the Treatment of Severe Acne Vulgaris” Protocol RD.03.SPR.29074; 2008-2009.

 

  1. Pfizer Inc.: “A Phase 2B, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial Evaluating The Efficacy And Safety Of Dose Regimens With Oral CP-690,550 In The Treatment Of Subjects With Moderate To Severe Chronic Plaque Psoriasis” Protocol A3921047; 2008-2010.

 

  1. Galderma: “Efficacy and Safety comparison of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel versus Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel Vehicle Gel as a 6-month Acne Maintenance Treatment” Protocol RD.03.SPR.29075; 2008-2009.

 

  1. Graceway Pharmaceuticals: “A Phase 3, Randomized, Double-blinded, Placebo-controlled, Multicenter Efficacy and Safety Study of Six Weeks of Treatment with Imiquimod Creams for Actinic Keratoses” Protocol GW01-0703; 2008-2009.

 

  1. Shionogi USA, Inc.: “A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Efficacy and Safety Study of Two Doses of S-777469 (400 mg BID and 800 mg BID) in Patients with Atopic Dermatitis” Protocol 0721D1424; 2008-2009.

 

  1. Stiefel Laboratories, Inc.: “A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-ranging Study to Investigate the Efficacy and Safety of 4 Dose Regimens of Oral Albaconazole in Subjects with Distal Subungual Onychomycosis” Protocol W0027-10; 2008-2009.

 

  1. Graceway Pharmaceuticals: “A Follow-up Study to Evaluate Sustained Clearance Rates of Actinic Keratoses up to One Year after Completion of Studies GW01-0702, GW01-0703, GW01-0704, and GW01-0705” Protocol GW01-0803; 2008-2010.

 

  1. Graceway Pharmaceuticals: “A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter, Efficacy and Safety Study of Imiquimod Creams in the Treatment of External Genital Warts” Protocol GW01-0805; 2008-2009.

 

  1. Amgen: “A Randomized Study to Evaluate the Efficacy and Safety of Adding Topical Therapy to Etanercept in Subjects with Moderate to Severe Plaque Psoriasis, Protocol 20080470,” 2008-2012.

 

  1. Merck:” A Phase IV Clinical Trial to Evaluate the Safety and Tolerability of ZOSTAVAX in Subjects >= 60 Years of Age, Protocol V211 020-01,” 2008-2009.

 

  1. Galderma: “Efficacy and Safety comparison of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel versus Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel Vehicle Gel as a 6-month Acne Maintenance Treatment, Protocol RD.03.SPR.29075,” 2008-2009.

 

  1. Epiphany Biosciences: “A Randomized, Double-blind, Active-controlled, Multi-center, Parallel-group Dose-ranging Study Assessing the Safety and Efficacy of EPB-348 Versus Valacyclovir Among Immunocompetent Patients with an Acute Episode of Herpes Zoster, Protocol EPB348-0201,” 2008-2009.

 

  1. Shionogi: “A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Efficacy and Safety Study of Two Doses of S-777469 (400 mg BID and 800 mg BID) in Patients with Atopic Dermatitis, Protocol 0721D1424,” 2008-2009.

 

  1. Inhibitex, Inc.: “A Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Comparative Study of FV-100 vs. Valacyclovir in Patients with Herpes Zoster” Protocol INH-FV1-005; 2009-2010.

 

  1. Basilea Pharmaceutica International, Ltd.: “Efficacy and Safety of Alitretinoin in the Treatment of Severe Chronic Hand Eczema Refractory to Topical Therapy” Protocol BAP01346; 2009-2011.

 

  1. Peplin Operations Pty Ltd: “A multi-center, Randomized, parallel group, double-blind, vehicle-controlled study to evaluate the Efficacy and safety of PEP005 (ingenol mebutate) Gel, 0.015% in patients with actinic keratoses ON the head (face or scalp) (REGION-IIa)” Protocol PEP005-016; 2009-2010.

 

  1. Taisho Pharmaceutical R&D Inc.: “A Multi-Center, Randomized, Double-Blind, Vehicle-Controlled Study of the Efficacy, Safety and Tolerability of TS-022 in Adults with a Diagnosis of Atopic Dermatitis (AD) with Moderate to Very Severe Pruritus” Protocol TS022-US201; 2009-2010.

 

  1. Amgen: “A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficiency and Safety of Adding Methotrexate to Etanercept in Subjects with Moderate to Severe Plaque Psoriasis, Protocol 20070559,” 2009-2011.

 

  1. Amgen: “A Phase 3 Mulicenter Study to Assess the Efficacy and Safety of Etanercept 50 mg Twice Weekly in Psoriasis, Protocol 20030117,” 2009-2010.

 

  1. Merck: “A Phase III Clinical Trial to Evaluate the Efficacy, Immunogenicity, Safety and Tolerabililty of ZOSTAVAX in subjects 50 to 59 Years of Age,” Protocol V211-022, 2009-2010.

 

  1. Peplin: “A 12 Month, Long-term Follow-up Study of Patients With Actinic Keratosis on the Head (face or scalp) who Have Completed Day 57 in Studies PEP005-016 or PEP005-025 (REGION IIa and IIb), Protocol PEP005-030,” 2009-2010.

 

  1. Amgen: “A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Etanercept in Treating Scalp Involvement in subjects with Moderate to Severe Plaque Psoriasis, Protocol 20080014,” 2008-2009.

 

  1. Amgen: “A Randomized, Double-blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects with Psoriasis, Protocol 20090062,” 2010-2011.

 

  1. Amgen: “A Randomized Study to Evaluate the Efficacy and Safety of Adding Topical Therapy to Etanercept in Subjects with Moderate to Severe Plaque Psoriasis, Protocol 20080470,” 2010-2011.

 

  1. NeurogesX: “A Multicenter Randomized, Double-blind, Controlled Study to Evaluate Safety, Tolerability and Preliminary Efficacy of Two Capsaicin Concentration Variations of NGX-1998 (10% or 20% w/w) in Subjects with Postherpetic Neuralgia (PHN), Protocol NEUROGESX PHN,” 2009-2011.

 

  1. Leo Pharmaceuticals: “Calcipotriol Plus Betamethasone Dipropionate Topical Suspension Compared to Betamethasone Dipropionate in the Topical Suspension Vehicle, Calcipotriol in the Topical Suspension Vehicle and the Topical Suspension Vehicle Alone in Psoriasis Vulgaris, Protocol LEO 80185-G23,” 2010-2011.

 

  1. Pfizer: “A Phase 3, Multi-site, Open-label Study of the Long Term Safety and Tolerability of 2 Oral Doses of CP-690,550 in Subjects with Moderate to Severe Chronic Plaque Psoriasis, Protocol A3921061,” 2010-Present.

 

  1. Amgen:” A Study To Evaluate the Safety of Long-term Exposure with AMG 827 in Subjects with Moderate to Severe Plaque Psoriasis, Protocol 20090403,” 2010-2016.

 

  1. Inhibitex: “A Sub-Study of the Pain Reduction Profile of 40-49 Year Old herpes Zoster Subjects Treated With Open-Label Valacyclovir Compared to Older Subjects in the Randomized, Double-Blind, Parallel-Group, Comparative Study, INH-FV1-005, Protocol INH-FV1-005-AGE,” 2010-2011.

 

  1. AiCuris: “A Double-Blind Randomized Placebo Controlled Dose-Finding Trial to Investigate Different Doses of a New Antiviral Drug in Subjects with Genital HSV Type 2 Infection, Protocol AIC-316-01-II-01,” 2010-2011.

 

  1. Pfizer: “Prevalence of Psoriatic Arthritis in Adults with Psoriasis: An Estimate from Dermatology Practice, Protocol 0081A6-4728,” 2010-2011.

 

  1. Pfizer: “A Phase 3, Multi-site, Randomized, Mixed-Blind, Parallel-Group Treatment Withdrawal and Re-Treatment Study of the Efficacy and Safety of 2 Oral Doses of CP-690,550 in Subjects with Moderate to Severe Chronic Plaque Psoriasis, Protocol A3921111,” 2010-2013.

 

  1. Galderma: “A Multi-center, Randomized, Double-Blind, Placebo-Controlled, 3-Arm, Parallel Group Study Comparing the Efficacy and Safety of CD2475/101 40mg Tablets versus Placebo and Doxycycline 100mg Capsules Once Daily in the Treatment of Inflammatory Lesions in Subjects with Acne Vulgaris, Protocol RD.06.SPR.18195,” 2010-2011.

 

  1. Inhibitex:” A Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Comparative Study of FV-100 vs. Valacyclovir in Patients with Herpes Zoster, Protocol INH-FV1-005,” 2010-2011.

 

  1. Celgene: “A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of Apremilast (CC-10004) in Subjects with Moderate to Severe Plaque Psoriasis, Protocol CC-10004-PSOR-009,” 2011-Present.

 

  1. Celgene:” A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Apremilast (CC-10004) in Subjects with Moderate to Severe Plaque Psoriasis, Protocol CC-10004-PSOR-008,” 2012-2015

 

  1. Maruho: “A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Multi-Center Phase IIb Dose Finding Study of M518101 in Plaque Psoriasis Patients, Protocol M51801-US01,” 2011-2012.

 

  1. Novartis: “ A Randomized, Double-blind, Placebo controlled, Multi-center Study of Subcutaneous Secukinumab to Demonstrate Efficacy after Twelve Weeks of Treatment, and to Assess the Safety, Tolerability and Long-Term Efficacy up to One Year in Subjects with Moderate to Severe Chronic Plaque-Type Psoriasis, Protocol CAIN457A2302,” 2011-2013.

 

  1. Celgene: “ A Phase 3, Multi-Center, Randomized, Double-blind, Placebo-controlled, Parallel-Group, Efficacy and Safety Study of Two Doses of Apremilast (CC-10004) in Subjects With Active Psoriatic Arthritis and a Qualifying Psoriasis Lesions, Protocol CC-10004-PSA-004,” 2011-Present

 

  1. Intendis: “ ADouble-Blind, Randomized,Vehicle-Controlled, Multi-Center, Multi-National, Parallel-Group Study of the Efficacy and Safety of ZK 245186 Ointment in Concentrations of 0.01, 0.03 and 0.1% Over 4 weeks in Patients with Atopic Dermatitis (AD), Protocol 1403380,” 2011-2012.

 

  1. Centocor: “A Phase 2 Multicenter, Randomized, Placebo- and Active-Comparator-Controlled, Dose-Ranging Trial to Evaluate CNTO 1959 for the Treatment of Subjects with Moderate to Severe Plaque-type Psoriasis, Protocol CNTO1959PSO2001,” 2011-2013.

 

  1. Pfizer: “A Phase 3, Multi-site, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Efficacy and Safety of 2 Oral Doses of CP-650,550 in Subjects With Moderate to Severe Chronic Plaque Psoriasis, Protocol A3921078,” 2011-2012.

 

  1. Celgene: “ A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Two Doses of Apremilast (CC-1004) in Subjects with Active Psoriatic Arthritis Who Have Not Been Previously Treated With Disease-Modifying AntiRheumatic Drugs, Protocol CC-10004-PSA-005,” 2011-Present.

 

  1. Celgene: “A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Two Doses Of Apremilast (CC-10004) In Subjects With Active Psoriatic Arthritis, Protocol CC-10004-PSA-002” 2011-2013

 

  1. Nycomed: “Antiviral and Immunomodulatory Effects of Veregen (sinecatechins ointment, 15%) in Patients with External Genital Warts: An Investigator-Initiated, Open-Label, Mechanism of Action Study, Protocol AIR2010-44-1002-01 MOA,” 2011-2012.

 

  1. Galderma: “A Phase 3 Randomized, Double-Blind, 12 Week Vehicle-Controlled, Parallel Group Study Assessing the Efficacy and Safety of CD5024 1 % Cream Versus Vehicle Cream in Subjects with Papulopustular Rosacea, Followed by a 40 Week Investigator Blinded Extension Comparing the Long-Term Safety of CD5024 1% Cream Versus Azelaic Acid 15 % gel, Protocol RD.06.SPR.1870,” 2011-2012.

 

  1. Galderma: “A Phase 3 Randomized, Double-Blind, 12 Week Vehicle-Controlled, Parallel Group Study Assessing the Efficacy and Safety of CD5024 1 % Cream Versus Vehicle Cream in Subjects with Papulopustular Rosacea, Followed by a 40 Week Investigator Blinded Extension Comparing the Long-Term Safety of CD5024 1% Cream Versus Azelaic Acid 15 % Gel, Protocol RD. 06. SPR.18171,” 2011-2013.

 

  1. Amgen: “An Open Label Study to Evaluate the Efficacy of Etancercept Treatment in Subjects with Moderate to Severe Plaque Psoriasis Who Have Lost a Satisfactory Response to Adalimumab, Protocol 20101145,” 2012-2015.

 

  1. Apo-Pharma: “A 12-week Randomized, Double-blind, Placebo-controlled, Multicenter, Multiple Sequential Dose Escalating Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of Apo805K1 in Subjects with Moderate to Severe Chronic Plaque Psoriasis, Protocol AP03-2010,” 2012-2013

 

  1. Pfizer: “A Phase 3, Multi-site, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of the Efficacy and Safety of 2 Oral Doses of CP-690,550 in Subjects With Moderate to Severe Chronic Plaque Psoriasis, Protocol A3921079,” 2012-2013.

 

  1. Novum: “A Randomized, Double-Blind, Placebo-Controlled, Multiple-Site, Study Comparing Metronidazole Topical Gel 1% (Taro Pharmaceutical Industries, Ltd.) to METROGEL (metronidazole gel) 1% (Galderma) in the Treatment of Moderate to Severe Rosacea, Protocol 71142601,” 2012-2013

 

  1. Idera: “A Randomized, Double-Blind, Placebo-Controlled, 4-week Trial of IMO-3100 in Patients With Moderate to Severe Plaque Psoriasis, Protocol 3100-202” 2012-2013

 

  1. Medicis: “A Parallel-group, Vehicle-controlled, Randomized, Double-blind Study of the Efficacy and Safety of Product 49778 and Product 10156 in Subjects With Seborrheic Dermatitis, Protocol MP-1001-01” 2012-2013

 

  1. Leo Pharma: “A Sequential Treatment Regimen of Cryotherapy and Picato® for the Treatment of Actinic Keratosis on the Face and Scalp, Protocol LP0041-21” 2012-2013.

 

  1. Eli Lilly: “A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Efficacy and Safety of LY2439821 to Etanercept and Placebo in Patients With Moderate-to-Severe Plaque Psoriasis, Protocol I1F-MC-RHBA” 2012-Present.

 

  1. Amgen: “A Phase 3 Study to Evaluate the Efficacy and Safety of Induction and Maintenance Regimens of Brodalumab Compared With Placebo and Ustekinumab in Subjects With Moderate to Severe Plaque Psoriasis, Protocol 20120104” 2012-2013.

 

  1. Genocea: “A Phase I/IIa, Randomized, Double-blind, Dose-ranging, Placebo-controlled Study of the Safety and Immunogenicity of a HSV-2 Vaccine Containing Matrix M-2 Adjuvant in Individuals With Documented Genital HSV-2 Genital Infection, Protocol GEN-003-001” 2012-2016

 

  1. Agenus: “A Phase 2a Multicenter, Double-blinded, Randomized Trial to Evaluate The Effect of HerpV on Viral Shedding in Adults With Recurrent Genital Herpes, Protocol C-400-02” 2012-2015.

 

  1. Galderma: “A Randomized, Multi-center, Investigator-blind, Vehicle- and Active-controlled, Phase 2 Study to Assess the Efficacy and Safety of Different Concentrations of CD5789 Cream Applied Once Daily in Subjects With Moderate to Severe Acne Vulgaris, Protocol RD.06.SPR.18223” 2012-2013.

 

  1. Asubio: “A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Parallel-group Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ASB17061 Capsules in Adult Subjects With Atopic Dermatitis, Protocol ASBI 704” 2012-2014.

 

  1. Merck: “A 64-Week, Phase 3, Randomized, Placebo-Controlled, Parallel Design Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous SCH 900222/MK-3222, Followed by an Optional Long-Term Safety Extension Study, in Subjects With Moderate-to-Severe Chronic Plaque Psoriasis, Protocol MK-3222-010” 2013-Present.

 

  1. Bayer: “A Randomized, Double-blind, Vehicle-controlled, Multicenter, Parallel-group Clinical Trial to Assess the Safety and Efficacy of Azelaic Acid Foam, 15% Topically Applied Twice Daily for 12 Weeks in Subjects With Papulopustular Rosacea, Protocol 1401846” 2013-2014.

 

  1. Novartis: “Phase II Randomized Double Blinded Placebo Controlled, Multiple-dose Regimen Study to Assess the Rate of Histological Clearance and Effect on Molecular Pathways as Well as on Biomarkers of 12 Months Secukinumab 300 mg s.c. Treated Patients With Chronic Plaque-type Psoriasis, Protocol CAIN457A2223” 2013-2015.

 

  1. Allergan: “A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of the Safety and Efficacy of a Single Treatment of AGN-214868 in Patients With Postherpetic Neuralgia, Protocol AGN 214868-007” 2013-2014.

 

  1. Maruho: “A Randomized, Vehicle Controlled, Double Blind, Parallel Group, Multi Center Phase III Study to Evaluate the Safety and Efficacy of M518101 in Subjects With Plaque Psoriasis, Protocol M518101-US02” 2013-2015.

 

  1. Novartis: “A Randomized, Double-blind, Placebo Controlled, Multicenter Study of Subcutaneous Secukinumab in Prefilled Syringes to Demonstrate Efficacy After Twelve Weeks of Treatment, and to Assess the Safety, Tolerability, Usability and Long-term Efficacy in Subjects With Chronic Plaque-type Psoriasis, Protocol CAIN457A2308” 2013-2017.

 

  1. Novartis: “A Multicenter, Double-blind, Randomized Withdrawal Extension Study of Subcutaneous Secukinumab in Prefilled Syringes to Demonstrate Long-term Efficacy, Safety, and Tolerability up to 2 Years in Subjects With Moderate to Severe Chronic Plaque-type Psoriasis Completing Preceding Psoriasis Phase III Studies With Secukinumab, Protocol CAIN457A2302E1” 2013-Present.

 

  1. Pfizer: “An Exploratory Phase 2A, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Assess Mechanism Of Action (MOA) Of CP-690,550 In The Skin When Administered Orally At 10 Mg Twice Daily (BID) For 12 Weeks In Subjects With Moderate To Severe Chronic Plaque Psoriasis, Protocol A3921147” 2013-2016.

 

  1. Regeneron: “A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study Investigating the Efficacy, Safety, Pharmacokinetic and Biomarker Profiles of REGN668 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis, Protocol R668-AD-1021” 2013-2014.

 

  1. Amgen: “A Phase 3 Study to Evaluate the Efficacy and Safety of Induction and Maintenance Regimens of Brodalumab Compared With Placebo and Ustekinumab in Subjects With Moderate to Severe Plaque Psoriasis, Protocol 20120103” 2013-2015

 

  1. Promius Pharma: “A Randomized, Double-Blind, Vehicle-Controlled, Multicenter, Parallel Group Study of the Efficacy and Safety of Betamethasone Dipropionate Spray 0.05% in the Treatment of Moderate Plaque Psoriasis, Protocol BDS1206” 2013-2016.

 

  1. Leo Pharma: “Safety and efficacy of escalating doses of ingenol mebutate once daily for two or three consecutive days when used on full face, full balding scalp or approximately 250 cm2 on the chest in subjects with actinic keratosis, Protocol LP0105-1012” 2013-2014
  2. Leo Pharma: “An Observational Study to Assess Patient Satisfaction and Control of Psoriasis With Calcipotriene/Betamethasone Dipropionate (Taclonex®) Topical Suspension, and Effect on Quality of Life, Protocol APPEAL” 2013-2014

 

  1. Vical: “A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation, Phase 1/2 Trial to Evaluate the Safety and Efficacy of Herpes Simplex Virus, Type 2 Therapeutic DNA Vaccines in Symptomatic HSV-2-Seropositive Adults, Protocol HSV2-101” 2013-2016.

 

  1. Allergan: “A Safety and Efficacy Study to Compare Dapsone Dermal Gel with Vehicle Control in Patients with Acne Vulgaris, Protocol 225678-007” 2013-2014.

 

  1. Regeneron: “An Open-label Study of Dupilumab in Patients With Atopic Dermatitis Who Participated in Previous Dupilumab Clinical Trials, Protocol R668-AD-1225” 2013-Present.

 

  1. Promius Pharma: “A Randomized, Double-Blind, Vehicle-Controlled, Multicenter, Parallel Group Study of the Safety of Betamethasone Dipropionate Spray 0.05% versus Diprolene® (augmented betamethasone dipropionate) Lotion 0.05% and the Efficacy of Betamethasone Dipropionate Spray 0.05% versus Vehicle Spray in the Treatment of Moderate Plaque Psoriasis, Protocol BDS1205” 2014-2016.

 

  1. Novartis: “A Randomized, Double-blind, Placebo-controlled, Multicenter, Study to Demonstrate the Efficacy at 16 Weeks of Secukinumab 150 and 300 mg s.c. and to Assess Safety, Tolerability and Longterm Efficacy up to 80 Weeks in Subjects With Moderate to Severe Nail Psoriasis, Protocol CAIN457A2313” 2014-2017.

 

  1. Novartis: “A 52-week, multicenter, randomized, double-blind study of subcutaneous secukinumab to demonstrate efficacy as assessed by Psoriasis Area and Severity Index at 16 weeks of treatment compared to ustekinumab and to assess long-term safety, tolerability and efficacy in subjects with moderate to severe plaque psoriasis, Protocol CAIN457A2317” 2014-2017.

 

  1. Amgen: “A Comparison of Psoriasis Symptom Severity and Health-Related Quality of Life in Patients With Clear and Almost Clear Levels of Skin Improvement, Protocol 20130127 (HRA 1889A)” 2014-2016.

 

  1. Merck: “A 52-Week, Phase 3, Randomized, Active Comparator and Placebo-Controlled, Parallel Design Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous SCH 900222 / MK-3222, Followed by an Optional Long-Term Safety Extension Study, in Subjects With Moderate-to-Severe Chronic Plaque Psoriasis, Protocol MK-3222-011” 2014-Present.

 

  1. Boehringer-Ingelheim: “A 48 weeks study of three different dose regimens of BI 655066 administered subcutaneously in patients with moderate to severe chronic plaque psoriasis (randomised, dose-ranging, active-comparator controlled (ustekinumab), double-blind within dose groups of BI 655066), Protocol 1311.2” 2014-2015.

 

  1. Promius Pharma: “A Randomized, Parallel, Open Label, Multicenter Study to Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing with Betamethasone Dipropionate Spray 0.05% versus Diprolene® (augmented betamethasone dipropionate) Lotion 0.05% in Subjects with Moderate to Severe Plaque Psoriasis, Protocol BDS1307” 2014-2016

 

  1. Amgen: “A Prospective, Observational Study to Estimate the Proportion of Subjects With Plaque Psoriasis who Achieve Complete Clearance on Biologics, Protocol 20120363” 2014-2016.

 

  1. Genocea: “A Randomized, Double-Blind, Factorial Study to Compare the Safety and Efficacy of Varying Combinations of GEN-003 and Matrix-M2 in Subjects With Genital HSV-2 Infection, Protocol GEN-003-002” 2014-2016.

 

 

  1. Regeneron: “A Randomized, Double-Blind, Placebo-Controlled, Study Investigating Vaccine Responses in Adults With Moderate to Severe Atopic Dermatitis Treated With Dupilumab, Protocol R668-AD-1314” 2014-2015.

 

  1. LEO Pharma: “Safety and Efficacy of Escalating Doses of LEO 43204 Applied Once Daily for Two Consecutive Days on Full Balding Scalp in Subjects With Actinic Keratosis, Protocol LP0084-1014” 2014-2015.

 

  1. Otsuka: “A Phase 2 Multi-center, Randomized, Double-blind, Vehicle-controlled, Three-arm, Parallel Group Study to Assess the Safety, Tolerability, and Efficacy of Topical OPA-15406 Ointment, in Subjects With Mild/Moderate Atopic Dermatitis, Protocol 271-12-205” 2014-2015.

 

  1. Anacor: “A Multicenter, Randomized, Double-Blind, Vehicle-Controlled Study of the Safety and Efficacy of AN2728 Topical Ointment, 2% in Children, Adolescents, and Adults (Ages 2 Years and Older) With Atopic Dermatitis, Protocol AN2728-AD-302” 2014-2015.

 

  1. Coherus: “A Double-Blind, Randomized, Parallel-Group, Active-Control Study to Compare the Efficacy and Safety of CHS-0214 versus Enbrel in Subjects with Chronic Plaque Psoriasis (RaPsOdy), Protocol CHS-0214-04” 2014-2016

 

  1. Janssen: “Exploratory Genetic Study in Subjects with Moderate to Severe Psoriasis, Protocol NOCOMPOUNDPSO0001” 2014.

 

  1. Sandoz: “A Randomized, Double-blind, Multicenter Study to Demonstrate Equivalent Efficacy and to Compare Safety and Immunogenicity of a Biosimilar Adalimumab (GP2017) and Humira® in Patients With Moderate to Severe Chronic Plaque-type Psoriasis, Protocol GP17-301” 2014-2016.

 

  1. Actavis: “A Randomized, Multicenter, Double-blind, Placebocontrolled Study to Evaluate the Efficacy and Safety of 1.5 mg/kg Per Day of Sarecycline Compared to Placebo in the Treatment of Acne Vulgaris, Protocol SC1401” 2014-2017.

 

  1. Janssen: “Phase 3, Multicenter, Randomized, Double-blind, Placebo and Active Comparator-controlled Study Evaluating the Efficacy and Safety of Guselkumab in the Treatment of Subjects With Moderate to Severe Plaque-type Psoriasis, Protocol CNTO1959PSO3001” 2014-Present.

 

  1. Janssen: “A Phase 3, Multicenter, Randomized, Double-blind, Placebo and Active Comparator-controlled Study Evaluating the Efficacy and Safety of Guselkumab for the Treatment of Subjects With Moderate to Severe Plaque-type Psoriasis With Randomized Withdrawal and Retreatment, Protocol CNTO1959PSO3002” 2014-Present.

 

  1. Janssen: “A Phase 3, Multicenter, Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Guselkumab for the Treatment of Subjects With Moderate to Severe Plaque-type Psoriasis and an Inadequate Response to Ustekinumab, Protocol CNTO1959PSO3003” 2014-2016.

 

  1. Dermira: “A Phase 3 Multicenter, Randomized, Double Blind, Parallel Group Study Followed by Dose Blind Period and Open Label Follow Up to Evaluate Efficacy and Safety of Certolizumab Pegol in Subjects With Moderate to Severe Chronic Plaque Psoriasis, Protocol PS0005” 2014-Present.

 

  1. Pfizer: “A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety and Efficacy of PF-04965842 in Subjects with Moderate to Severe Psoriasis, Protocol B7451005” 2014-2016.

 

  1. Polynoma: “A Multicenter, Double-blind, Placebo-controlled, Adaptive Phase 3 Trial of POL-103A Polyvalent Melanoma Vaccine in Post-resection Melanoma Patients With a High Risk of Recurrence, Protocol POL-103A” 2015-Present.

 

  1. Regeneron: “A Phase 3 Confirmatory Study Investigating the Efficacy and Safety of Dupilumab Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis, Protocol R668-AD-1416” 2015-2016.

 

  1. Boehringer Ingelheim: “An Open Label Extension Trial Assessing the Safety and Efficacy of BI 655066 Administered Subcutaneously in Patients With Moderate to Severe Chronic Plaque Psoriasis Protocol 1311.13” 2015-Present.

 

  1. Medimmune: “A Phase 2b, Randomized, Double-blinded, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy and Safety of Tralokinumab in Adult Subjects With Moderate-to-Severe Atopic Dermatitis, Protocol D2213C00001” 2015-2016.

 

  1. Tolmar: “A Double-blind, Randomized, Parallel-group, Vehicle-controlled, Multicenter Study Comparing TOLMAR Calcipotriene Ointment, 0.005% to Reference Listed Drug in the Treatment of Plaque Psoriasis, Protocol TOL2707A” 2015-2016.

 

  1. Genocea: “Rollover Trial for Placebo Subjects Previously Enrolled into GEN-003-002 – A Randomized, Double-Blind, Factorial Study to Compare the Safety and Efficacy of Varying Combinations of GEN-003 and Matrix-M2 in Subjects with Genital HSV-2 Infection, Protocol GEN-003-002a” 2015-2016

 

  1. LEO Pharma: “Safety of LEO 43204 0.018%, 0.037% and 0.1% for actinic keratosis applied once daily for three consecutive days on face/chest, scalp and trunk/extremities, respectively, Protocol LP0084-1148” 2015-2016.

 

  1. LEO Pharma: “Efficacy and Safety of Ingenol Mebutate Gel in Field Treatment of Actinic Keratosis on Full Face, Balding Scalp or Approximately 250 cm2 on the Chest, Protocol LP0105-1032” 2015-2017.

 

  1. Actavis: “A Multi-Center Open-Label Evaluation of the Safety of Sarecycline Tablets in the Treatment of Acne Vulgaris, Protocol SC1403” 2015-2016.

 

  1. Dermira: “A Phase 2, Randomized, Double-Blind, Vehicle-Controlled, Dose-Ranging, Study of DRM01B Topical Gel in Subjects with Acne Vulgaris, Protocol DRM01B-ACN02” 2015-2016

 

  1. Novartis: “A randomized, vehicle controlled, active comparator, parallel group study to evaluate efficacy, safety, and tolerability of topical LFX453 formulations in patients with external genital warts (EGWs), Protocol CLFX453X2202” 2015-2016.

 

  1. LEO Pharma: “Efficacy and safety of LEO 43204 in field treatment of Actinic keratosis on face or chest including 12 month follow- up, Protocol LP0084-1193”2015-Present.

 

  1. LEO Pharma: “ Efficacy and safety of LEO 43204 in Field Treatment of Actinic Keratosis on Balding Scalp including 12- month follow- up, Protocol LP0084-1195” 2015- Present.

 

  1. Cutanea: “ A Phase 2, Randomized, Double- Blind, Vehicle- Controlled, Parallel Group Multicenter Study to Evaluate the Safety and Efficacy of CLS001 Topical Gel versus Vehicle Applied Once Daily for 12 Weeks to Female Subjects with Moderate to Severe Acne Vulgaris, Protocol CLS001-CO-PR-009” 2015- 2016.

 

  1. Hologic: “Clinical Evaluation of the Aptima Herpes Simplex Viruses 1 & 2 Assay on the Panther System in Swab Specimens From Symptomatic Subjects Presenting With a Suspected Herpes Lesion(s)” 2015- 2016.

 

  1. Coherus: “ A Double- Blind, Randomized, Parallel- Group, Active- Control Study to Compare the Efficacy and Safety of CHS- 1420 Versus Humira in Subjects with Chronic Plaque Psoriasis, Protocol CHS-1420-02” 2015- 2017.

 

  1. Contravir: “ A Multicenter, Randomized, Double- Blind, Parallel- Group, Comparative Study of FV-100 vs. Valacyclovir for the Prevention of Post- Herpetic Neuralgia and Treatment of Acute Herpes Zoster- Associated Pain, Protocol CTRV-FV-2-007” 2015-Present.

 

  1. Novan: “A Phase 2 Multi-Center, Double- Blind, Randomized, Vehicle- Controlled, Ascending Dose Study assessing Tolerability, Safety, and Efficacy of Topical NVN1000 in Subjects with External Genital Warts and Perianal Warts, 2015- 2016.

 

  1. Valeant: “ A Pase 3, Multi- Center, Randomized, Double- Blind, Vehicle- Controlled, 2- Arm, Parallel Group Comparison Study Comparing the Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris, Protocol V01-121A-301” 2015- 2017.

 

  1. Eli Lilly: “ A Multicenter, Randomized, Double- Blind Study Comparing the
    Efficacy and Safety of Ixekizumab dosing Regimens in Patients with Moderate- to – Severe Plaque Psoriasis, Protocol I1F-MC- RHBP(a)” 2015- 2017.

 

  1. Galderma: “ A Multicenter, Randomized, Double- Blind, Parallel- Group Vehicle Controlled Study To Compare The Efficacy And Safety of CD5789 Cream Versus Vehicle Cream In Subjects With Acne Vulgaris, Protocol RD.06.SPR.18252” 2015- Present.

 

  1. GlaxoSmithKline: “Study 203121: A Randomized, Blinded, Vehicle- Controlled, Dose- Finding Study of GSK 2894512 Cream for the Treatment of Atopic Dermatitis” 2015- 2017.

 

  1. GlaxoSmithKline: “Study 203120: A Randomized, Blinded, Vehicle- Controlled, Dose- Finding Study of GSK 2894512 Cream for the Treatment of Plaque Psoriasis” 2015- 2016.

 

  1. Vitae Pharmaceuticals: A Randomized, double- Blind, Placebo- controlled Ascending Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VTP-43742 in Health volunteers and Proof-of- Concept in Psoriatic Patients” 2015- 2016

 

  1. Valeant: “A Phase 3, Multicenter, Open Label Study to Evaluate the Long- Term Safety of IDP- 118 Lotion in the Treatment of Plaque Psoriasis, Protocol V01-118A-303” 2015- 2017.

 

  1. Valeant: “A Phase 3, Multicenter, Double- Blind, Randomized, Vehicle Controlled Clinical Study to Assess the Safety and Efficacy of IDP-118 in the Treatment of Plaque Psoriasis, Protocol V01-118A-302” 2015- 2016.

 

  1. Lilly Chorus: “ A Randomized, Double- Blind, Placebo- Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of Baricitinib in Patients with Moderate- to- Severe Atopic Dermatitis, Protocol I4V-MC-JAHG (a)” 2016-2017.

 

  1. Boehringer Ingelheim: “BI 655066 versus placebo In a Multicenter randomized double blind study in patients with Moderate to severe chronic plaque psoriasis evaluating the efficacy and safety with randomized withdrawal and re- treatment, Protocol BIPI 1311.4” 2016- Present.

 

  1. Boehringer Ingelheim: “BI 655066 versus Ustekinumab and placebo comparators in a randomized double blind trials for Maintenance use in Moderate to severe plaquetype psoriasis, Protocol BIPI 1311.3” 2016- Present.

 

  1. Novartis: A randomized, double- blind, placebo- controlled, parallel- group, multicenter study to evaluate the effect of secukinumab on aortic vascular inflammation and cardiometaboloic biomarkers after 12 weeks of treatment, compared to placebo, and up to 52 weeks of treatment with secukinumab in adult subjects with moderate to severe chronic plaque- type psoriasis, Protocol CAIN457AUS02” 2016- Present.

 

  1. Abbvie: “A Phase 2b Multicenter, Randomized, Placebo-Controlled, Double-Blind Dose-Ranging Study to Evaluate ABT-494 in Adult Subjects with Moderate to Severe Atopic Dermatitis”, Protocol M16-048 2016- Present

 

  1. Genocea: “A Long-term Follow-up Study of Efficacy and Immunogenicity of GEN-003 in Subjects with Genital Herpes Simplex Virus Type 2 (HSV-2) Infection”, Protocol: GEN-003-002b 2016- Present

 

  1. UCB Biopharma: “A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, DOSE RANGING STUDY TO EVALUATE THE SAFETY, EFFICACY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF BIMEKIZUMAB IN ADULT SUBJECTS WITH MODERATE TO SEVERE CHRONIC PLAQUE PSORIASIS; PHASE 2B,Protocol: PS0010 2016- Present

 

  1. UCB Biopharma: “A MULTICENTER, 48-WEEK, OPEN-LABEL EXTENSION STUDY TO ASSESS THE LONG-TERM SAFETY,TOLERABILITY, AND EFFICACY OF BIMEKIZUMAB IN ADULT SUBJECTS WITH MODERATE TO SEVERE CHRONIC PLAQUE PSORIASIS, Protocol: PS0011 2016-Present

 

  1. Incyte: “INCB 18424-206: “A Phase 2, Randomized, Dose-Ranging, Vehicle-Controlled and Triamcinolone 0.1% Cream-Controlled Study to Evaluate the Safety and Efficacy of INCB018424 Phosphate Cream Applied Topically to Adults With Atopic Dermatitis”, Protocol: INCB18424-206 , 2016- Present

 

  1. Glenmark: A Phase 2a, Double-Blind, Randomized, Placebo-controlled, Exploratory Study to Evaluate the Safety, Biological Activity and Pharmacokinetics of GBR 830 in Adult Patients With Moderate-to-Severe Atopic Dermatitis, Protocol: GBR 830-201, 2016- Present

 

  1. Novartis: A multicenter, randomized, double-blind, placebo-controlled, 52-weeks study to demonstrate the efficacy, safety and tolerability of subcutaneous secukinumAb injections with 2mL pre-fiLLed syringes (300 mg) in adUlt subjects with moderate to seveRE plaque psoriasis, Protocol: CAIN457A2323, 2017- Present

 

  1. Cellceutix: A Randomized, Double Blind, Parallel Group, Placebo-controlled Trial to Study the Efficacy and Safety of Two Oral Doses of Prurisol Administered Twice Daily for Twelve Weeks to Subjects with Moderate to Severe Chronic Plaque Psoriasis. Protocol:CTIX-PRU-005, 2017- Present

 

  1. Roivant (Innovaderm): Phase 2 Study of RVT-501 in Adult and Adolescent Subjects with Atopic Dermatitis, Protocol: RVT-501-2001, 2017-Present

 

  1. Abbvie: A multicenter, open Label study to assess the safety and efficacy of rIsankizuMab for MaInTenance in moderate to severe pLaquE type pSoriaSis (LIMMITLESS), Protocol: M15-997, 2017- Present

 

  1. Topstone: A Randomised, Double-blind, Vehicle-Controlled, Phase IIb Study to Assess the Efficacy and Safety of Topically Applied DS107 Cream to Adults with Mild to Moderate Atopic Dermatitis. Protocol: DS107E-06, 2017- Present

 

 

 

VACCINE DEVELOPMENT AND TESTING

 

  1. Chiron Corp.: “A Phase III, Randomized, Double‑Blind, Placebo‑Controlled, Multi‑Center Study of the Efficacy of an HSV Vaccine Composed of Recombinant Herpes Simplex Virus Type 2 (HSV‑2) Subunit Antigens Combined with MF 59 Adjuvant Emulsion when Given to HSV‑2 Seronegative Monogamous Sex Partners of Persons with Genital Herpes Type 2, Protocol V5P16,” 1994‑1996.

 

  1. Chiron Corp.: “A Phase III, Double Blind, Randomized, Parallel Design, Multi Center, Lot‑to‑Lot Consistency Study of the Safety, Tolerability, and Immunogenicity of an HSV Vaccine Composed of Recombinant Herpes Simplex Virus Type 2 (HSV‑2) Subunit Antigens Combined with MF59 Adjuvant Emulsion When Given to Healthy HSV‑2 Seronegative Adults, Protocol V5P17” 1995-1996.

 

  1. Chiron Corp.: “A Phase III, Double Blind, Randomized, Placebo‑Controlled, Parallel Multi Center Study of the Efficacy of a Fourth Immunization with an HSV Vaccine Composed of Combined Recombinant Herpes Simplex Virus Type 2 Subunit Antigens Combined with MF59 Adjuvant Emulsion when given to Previously Immunized Subjects in Protocol V5P16, Protocol V5P12” 1995‑1997.

 

  1. Chiron Corp.: “A Phase III, Randomized, Double‑Blind, Placebo‑Controlled, Multi Center Study of the Efficacy of an HSV Vaccine Composed of Recombinant Herpes Simplex Virus Type 2 (HSV-2) Subunit Antigens Combined with MF 59 Adjuvant Emulsion When Given to HSV‑2 Seronegative Adults at High Risk for Acquisition of Sexually Transmitted Diseases, Protocol V5P15” 1994-1996.

 

  1. SmithKline Beecham Biologicals: “A Double‑Blind, Randomized, Placebo‑Controlled Study to Evaluate the Efficacy of SmithKline Beecham Biologicals’ Herpes Simplex Candidate Vaccine (gD2t) with MPL to Prevent Genital Herpes Disease in Healthy Consorts of Subjects with Genital Herpes Disease, Protocol 007” 1994‑1998.

 

  1. SmithKline Beecham Biologicals: “A Double‑Blind, Randomized, Placebo‑Controlled, Study to Evaluate the Safety of SmithKline Beecham Biologicals’ Herpes Simplex Candidate Vaccine (gD2t) with MPL and its Efficacy to Prevent Genital Herpes Disease in HSV Positive or Negative Consorts of Subjects with Genital Herpes Disease, Protocol 017” 1995‑1998.

 

  1. SmithKline Beecham Biologicals: “A Double‑Blind, Randomized, Placebo‑Controlled, Study to Evaluate the Safety of SmithKline Beecham Biologicals’ Herpes Simplex Candidate Vaccine (gD2t) with MPL in HSV Seropositive or Seronegative Subjects Without Genital Herpes Disease, Protocol 016” 1995-1997.

 

  1. VaxGen, Inc.: “A Phase III Trial to Determine the Efficacy of Bivalent AIDSVAX B/B Vaccine in Adults at Risk of Sexually Transmitted HIV‑I Infection in North America” 1998‑2003.

 

  1. Merck & Company, Inc.: “Multicenter, Randomized, Double‑Blind Study to Evaluate the Safety, Tolerability, and Immunogenicity of a 2‑dose Regimen of High Titered Process Upgrade Varicella Vaccine (PUVV) in subjects ³13 Years of Age” 1999‑2001.

 

  1. Glaxo Wellcome, Inc.: “A Phase II, Randomized, Double‑Blind, Placebo‑Controlled Study to Assess the Efficacy and Safety of TA‑HSV(GW419458X) Vaccine for the Treatment of Recurrent Herpes Genitalis” 1999‑2001.

 

  1. Med Immune: “A Phase II Double‑Blind, Randomized, Dose‑Comparison Study to Evaluate the Safety and Immunogenicity of MEDI‑517, a Virus‑Like Particle Vaccine Against Human Papillomavirus Types 16 and 18, in Healthy Adult Female Volunteers, Protocol MI‑CP057” 1999-2001.

 

  1. Med Immune: “A Phase I Study to Evaluate the Safety and Immunogenicity of MEDI‑517, a Virus‑like Particle Vaccine against Human Papillomavirus (HPV) Types 16 and 18, in Healthy Adult Female Volunteers who are HPV‑16 or HPV‑18 DNA Positive, Protocol MI‑CP058” 1999‑2001.

 

  1. SmithKline Beecham Biologicals: “A Multicenter, Epidemiology Study to Evaluate the Prevalence of Human Papillomavirus (HPV) Infections in Adolescent and Adult Females in North America and Brazil, Protocol HPV-106” 2000-2001.

 

  1. SmithKline Beecham Biologicals: “A Double-Blind Placebo-controlled, Randomised, Pilot Phase IIB Study of the Efficacy of an HPV-16/18 VLP vaccine in the Prevention of HPV-16 and/or HPV-18 Cervical Infection in Healthy Adolescent and Young Adult Women in North America and Brazil, Protocol HPV-001” 2001-2004.

 

  1. Merck & Co., Inc: “A Double-Blind Placebo Controlled, Randomized Study to Evaluate Safety, Tolerability and Immunogenicity After One and Two Doses of PHN/Zoster Vaccine, Protocol 007-00” 2001-2005.

 

  1. GlaxoSmithKline Biologicals’: “Open Study to Further Evaluate the Safety, Reactogenicity, and Immunogenicity of GlaxoSmithKline Biologicals’ Prophylactic Herpes Simplex Candidate Vaccine with gD-alum-MPL in HSV-1 and HSV-2 Seronegative (HSV 1-/2-) Women Who Previously Received Either, Alum-MPL or Alum as Placebo During One of GlaxoSmithKline Biologicals’ Phase III Studies 208141/005 (HSV-007), 208141/016 (HSV-016) or 208141/017 (HSV-017), Protocol 038” 2002-2004.

 

  1. GlaxoSmithKline: “A phase IIb, blinded, multi-center, long-term follow-up study of the efficacy of candidate HPV-16/18 VLP vaccine in the prevention of HPV-16 and/or HPV-18 cervical infection in adolescent and young adult women in North America and Brazil vaccinated in primary study 580299/001” Protocol 58099/007; 2003-2004.

 

  1. Merck: “A multicenter, double-blind, randomized, placebo-controlled probe study with an additional open-label control arm to evaluate the safety and immunogenicity of a 3-dose regimen of the MRKAd5 HIV-1 gag vaccine in subjects with chronic hepatitis C virus infection” Protocol 022; 2004-2005.

 

  1. PowderJect Vaccines Inc: “A phase I, single-center, open-label, dose-escalating study to investigate the safety, tolerability and immunogenicity of PPJV7630, a therapeutic DNA vaccine for herpes simplex virus type 2 (HSV-2) in subjects with recurrent genital herpes caused by HSV-2” Protocol PJ HSV-001; 2004-2006.

 

  1. GlaxoSmithKline: “A phase III, double-blind, randomized, controlled, multi-center study to evaluate the efficacy of GlaxoSmithKline Biologicals’ HPV-16/18 VLP/AS04 vaccine compared to hepatitis A vaccine as control in prevention of persistent HPV-16 or HPV-18 cervical infection and cervical neoplasia, administered intramuscularly according to a 0, 1, 6 month schedule in healthy females 15-25 years of age” Protocol 58099/008; 2004-2006.

 

  1. Merck: “A multicenter, double-blind, randomized, placebo-controlled phase II proof-of-concept study to evaluate the safety and efficacy of a 3-dose regimen of the Merck Adenovirus Serotype 5 HIV-1 gag/pol/nef vaccine (MRKAd5 HIV-1 gag/pol/nef) in adults at high risk of HIV-1 infection” Protocol V520/023-01; 2004-2009.

 

  1. Merck: “A phase III clinical trial to study the safety, tolerability and immunogenicity of zoster vaccine live (Oka/Merck) in subjects with a history of herpes zoster” Protocol V211/014-00; 2006-2008.

 

  1. Merck & Co., Inc: “A Phase IV Clinical Trial to Evaluate the Safety and Tolerability of ZOSTAVAX™ in Subjects ≥ 60 Years of Age” V211-020-00; 2007-2009.

 

  1. Merck & Co., Inc.: “A Phase III Clinical Trial to Evaluate the Efficacy, Immunogenicity, Safety and Tolerabililty of ZOSTAVAX in subjects 50 to 59 Years of Age” Protocol V211-022; 2007-2009.

 

  1. Merck & Co., Inc.: “A Double-blind, Randomized, Placebo-Controlled, Parallel Group Study to Evaluate Biomarkers of Immunity to Varicella Zoster Virus Following Immunization with V212/Heat-Treated Varicella-Zoster Virus (VAV) Vaccine or with ZOSTAVAX™ in Healthy Volunteers” Protocol V212-003; 2009-2011.

 

  1. GlaxoSmithKline: “Safety study of GSK Biologicals’ human papillomavirus vaccine (GSK580299) in female American and Canadian subjects who had received control vaccine in study 580299/008” Protocol HPV 111955/057); 2009-2010.

 

  1. Merck: “A Double-Blind, Randomized, Placebo-Controlled, Parallel Group Study to Evaluate Biomarkers of Immunity to Varicella Zoster Virus Following Immunization with V212/Heat Treated Varicella-Zoster Virus (VZV) Vaccine or with Zostavax in Health Volunteers, Protocol V212-003,” 2009-2010.

 

  1. Merck:” An Observational Follow-up of Adult Participants Enrolled in the Step Study (Merck V520 Protocol 023/HVTN 502), A 3-dose Regimen of the Merck MRK Ad5 HIV-1 gag/pol/nef Vaccine or Placebo, Protocol V520-030/HVTN 504,” 2009-2010.

 

 

PUBLICATIONS IN JOURNALS, CHAPTERS, MONOGRAPHS AND BOOKS    

 

ARTICLES IN PEER-REVIEWED JOURNALS (BASIC, BASIC & CLINICAL, CLINICAL)

 

  1. BASIC RESEARCH

 

  1. Tyring, S.K., F. Churchill, and W. Stevens. A seasonal bacterial survey of the honey mesquite (Prosopis glandulosa var. glandulosa Torr.). Biol. J. 4:39-49; 1978.

 

  1. Tyring, S.K., K. Klager, A. Luk, F. Messiha, and S. Lefkowitz. Ethanol, disulfiram and pyrazole: effects on interferon production in mice. Immunopharm. 2:63-72; 1979.

 

  1. Tyring, S.K., and S. Lefkowitz. Strain differences in production of murine interferons. S.E.B.M. 164:519-523; 1980.

 

  1. Tyring, S.K., and S. Lefkowitz. Induction of interferon by levamisole and concanavalin A in HA/ICR and NZB/W mouse spleen cells. Experientia 36:1323-1324; 1980.

 

  1. Nemeth, D., K. Tyring, and S. Lefkowitz. Hematological and immunological effects of methadone administration in mice. Res. Comm. In Substance Abuse 1:177-183; 1980.

 

  1. Tyring, S.K., A. Luk, and S. Lefkowitz. Antiviral action of murine interferons on heterologous cells. Intervirology 15:223-227; 1981.

 

  1. Tyring, S.K., G. Klimpel, W. Fleischmann, and S. Baron. Direct cytolysis by partially-purified preparations of immune interferon. J. Cancer 30:59-64; 1982.

 

  1. Tyring, S.K., A. Luk, and S. Lefkowitz. Priming of L cells by murine immune interferon. Intervirology 19:144-148; 1983.

 

  1. Fleischmann, W., G. Klimpel, K. Tyring, and S. Baron. Interferon: antitumor actions. Transplantation Proc. 16:516-523; 1984.

 

  1. Tyring, S.K., G. Klimpel, M. Brysk, V. Gupta, G.J. Stanton, W. Fleischmann, and S. Baron. Eradication of cultured human melanoma cells by IFN gamma and leukocytes. Natl. Cancer Inst. 73:1067-1073; 1984.

 

  1. Reyes, V., A. Luk, K. Tyring, G. Hillman, and S. Lefkowitz. Properties of bovine interferons. Experientia 40:1410-1412; 1984.

 

  1. Tyring, S.K., W. Fleischmann, and S. Baron. A convenient microassay for cytolysis and cytostasis. Enzymol. 119:574-579; 1986.

 

  1. Sarzotti, M., S. Baron, K. Tyring, and G.R. Klimpel. Interferon-mediated protection of B16 melanoma cells from cytotoxicity by activated macrophages. Cell Immunol. 100:280-287; 1986.

 

  1. Tyring, S.K., C. Albrecht, M. Brysk, W.R. Fleischmann, Jr., and S. Baron. Interferon-induced cytolysis correlates with the degree of transformation of epidermal cells. Invest. Dermatol. 89:136-141; 1987.

 

  1. Ghanta, V.K., N.S. Hiramoto, H.B. Solvason, K. Tyring, H.N. Spector, and R.N. Hiramoto. Conditional enhancement of natural killer cell activity, but not interferon, with camphor or saccharin-LiCl conditioned stimulus. J. Neurosci. Res. 18 :10-15 ; 1987.

 

  1. Fine, J.D., K. Tyring, and W. R. Gammon. The presence of intra-lamina lucida formation in epidermolysis bullosa acquisita: possible role of leukocytes. J. Invest. Dermatol. 92:27-32; 1989.

 

  1. Tyring, S.K., R. Cauda, M. Tumbarello, L. Ortona, R. Kennedy, T. Chanh, and P. Kanda. Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin 1 and tumor necrosis factor but depress production of interferon alpha, interferon gamma and interleukin 2. Viral Immunol. 4:33-42; 1991.

 

  1. Evers, M., S. Hurlbut, K. Tyring, C. Townsend, T. Uchida, and J. Thompson. Novel therapy for the treatment of human carcinoid. Ann. Surg. 213:411-416; 1991.

 

  1. Brysk, M.M., T. Bell, K. Tyring, and S. Rajaraman. Interferon gamma modulates terminal differentiation and the expression of desquamin in cultured keratinocytes. Exp. Cell Res. 191:140-147; 1991.

 

  1. Brysk, M.M., C.H. Santschi, T. Bell, R.J. Wagner, K. Tyring, and S. Rajaraman. Culture of basal cell carcinoma. J. Invest. Dermatol. 98:45-49; 1992.

 

  1. Rady, P., F. Scinicariello, R.F. Wagner Jr., and K. Tyring. P53 mutations in basal cell carcinomas. Cancer Res. 52:3804-3806; 1992.

 

  1. Rady, P.L., R. Chin, T.K. Hughes, and K. Tyring. Direct sequencing of consensus primer generated PCR fragments of human papillomaviruses. J. Virol. Meth. 43:335-350; 1993.

 

  1. Boldogh, I., E.-S. Huang, Rady, I. Arany, S.K. Tyring, and T. Albrecht. Alteration in the coding potential and expression of H-ras in human cytomegalovirus-transformed cells. Intervirology 37:321-329; 1994.

 

  1. Hughes, T.K., P. Cadet, P.L. Rady, K. Tyring, R. Chin, and E.M. Smith. Evidence for the production and action of interleukin 10 in pituitary cells. Cell. Molec. Neurobiol. 14:59-69; 1994.

 

  1. Brysk, M.M., T. Bell, K. Tyring, and S. Rajaraman. Cytokines modulate terminal differentiation and the expression of predesquamin in cultured keratinocytes. Exp. Cell Res. 211:49-52; 1994.

 

  1. Hughes, T.K., R. Chin, K. Tyring, and P.L. Rady. Distinction of mouse interferon a-subtypes by polymerase chain reaction utilizing consensus primers and type-specific oligonucleotide probes. J. Interferon Res. 14:117-120; 1994.

 

  1. Hsuem, C.M., K. Tyring, R.N. Hiramoto, and V.K. Ghanta. Efferent signals responsible for the conditional augmentation of natural killer cell activity. Neuroimmunomodulation 1: 74-81; 1994.

 

  1. Hughes, T.K., R. Chin, K. Tyring, and P.L. Rady. Distinction of mouse interferon a subtypes by polymerase chain reaction utilizing consensus primers and type specific oligonucleotide probes. J. Interferon Res. 14:117-120; 1994.

 

  1. Payne, D., S. Hoskins, H. Schowten, H. VanVleuken, and K. Tyring. Increased buffer pH enhances sensitivity and specificity of human papillomavirus detection using consensus primer based PCR. J. Virol. Meth. 52:105-110; 1995.

 

  1. Brysk, M.M., P. Selvanayagam, I. Arany, H. Brysk, K. Tyring, and S. Rajaraman. Induction of apoptotic nuclei by interferon g and by predesquamin in cultured keratinocytes. J. Interferon Cytokine Res. 15:1029-1035; 1995.

 

  1. Brysk, M.M., I. Arany, H. Brysk, S.H. Chen, K.M. Calhoun, and K. Tyring. Gene expression of markers associated with proliferation and differentiation in human keratinocytes cultured from epidermis and from buccal mucosa. Arch. Oral Biol. 40: 855-862; 1995.

 

  1. Brysk, M.M., I. Arany, H. Brysk, S-H Chen, K.H. Calhoun, and K. Tyring. Epithelial cell responsiveness to interferon g: Epidermis vs. buccal mucosa. Mol. Cell. Differ. 3:213-223; 1995.

 

  1. Rady, P.L., I. Arany, T.K. Hughes, and K. Tyring. Type specific primer mediated direct sequencing of consensus primer generated PCR amplicons of human papillomaviruses: A new approach for the simultaneous detection of multiple viral type infections. J. Virol. Meth.  53:245-254; 1995.

 

  1. Rady, P.L., P. Cadet, T.K. Bui, K. Tyring, S. Baron, G.J. Stanton, and T.K. Hughes. Production of interferon g messenger RNA by cells of non-immune origin. Cytokines 7:793-798; 1995.

 

  1. Memar, O.M., S. Rajaraman, R. Thotakura, K. Tyring, J.L. Fan, G.S. Seetharamaiah, R.E. A. Lopez, R. E. Jordan, and B.S. Prabhakar. Recombinant desmoglein 3 has the necessary epitopes to absorb and induce blister-causing antibodies. J. Invest. Derm. 106:261-268; 1996.

 

  1. Opp, M.R., P. Rady, T.K. Hughes, Jr., P. Cadet, K. Tyring, and E.M. Smith. Human immunodeficiency virus envelope glycoprotein 120 alters sleep and induces cytokine mRNA expression in rats. Am. J. Physiol. 270:R963-R970; 1996.

 

  1. Zhou, W., K. Tyring, M. Brysk, and T.-S. Chan. Immortalization of differentiated human keratinocytes by human papillomavirus (HPV) 16 DNA. J. Dermatol. Sci. 13:140-152; 1996.

 

  1. Memar, O., B. Christensen, S. Rajaraman, R. Goldblum, K. Tyring, M.M. Brysk, D.J. McCormick, and B.S. Prabhakar. Induction of blister-causing antibodies by a recombinant full-length, but not the extracellular domain of the pemphigus vulgaris antigen (desmoglein 3). J. Immunol. 157:3171-3177; 1996.

 

  1. Arany, I., M.M. Brysk, K.H. Calhoun, and K. Tyring. Differentiation and IFN g regulate WAF1/CIP1 transcription of p 53-independent and p53 dependent pathways in epithelial cells. In Vivo 10: 119-124; 1996.

 

  1. Arany, I., M.M. Brysk, H. Brysk, and K. Tyring. Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes. Biochem. Biophys. Res. Commun. 220:618-622; 1996.

 

  1. Arany, I., K. Tyring, S.L. Hoskins, H. Brysk, S-H. Chen, P. Selvanayagam, S. Rajaraman, and M.M. Brysk. Response of cultured cells from the epidermis and the buccal mucosa to TGF-b1 and comparison to interferon-g. In Vivo 10: 405-410; 1996.

 

  1. Arany, I., M.M. Brysk., H. Brysk, and K. Tyring. Induction of iNOS mRNA by interferon-g in epithelial cells is associated with growth arrest and differentiation. Cancer Lett. 110:93-96; 1996.

 

  1. Brysk, M.M., G. Lei, S. Rajaraman, P. Selvanayagam, C.H. Rassekh, H. Brysk, K. Tyring, and I. Arany. Gene expression of zinc-a2-glycoprotein in normal human epidermal and buccal epithelia. In Vivo 11:271; 1997.

 

  1. Trocme, S.D., C.K. Hallberg, K.S. Gill, G.J. Gleich, K. Tyring, and M.M. Brysk. Effects of eosinophil granule proteins on human corneal epithelium cell viability and morphology. Invest. Ophthal. Visual Sci. 38:593-599; 1997.

 

  1. Arany, I., M. Arany, H. Brysk, K. Tyring, and M.M. Brysk. Interferons a, b and g induce different patterns of gene expression in cultured human epidermal keratinocytes.  In Vivo 11:157-161; 1997.

 

  1. Lei, G., I. Arany, P. Selvanayagam, S. Rajaraman, S. Ram, H. Brysk, K. Tyring, and M.M. Brysk. Detection and cloning of epidermal zinc-a2 –glycoprotein CDNA and gene expression in normal human skin and in tumors. J. Cell. Biochem. 67:216-22; 1997.

 

  1. Brysk, M.M., G. Lei, P. Selvanayagam, H. Brysk, K. Tyring, and I. Arany. Modulation by interferon-g of zinc-a2-glycoprotein gene expression in human epithelial cell lines. Anticancer Res. 17:3387-3392; 1997.

 

  1. Arany, I., C.M. Fleischmann, K. Tyring, and W. R. Fleischmann, Jr. Interferon regulates expression of mda-6/WAF1/CIP1 and cyclin-dependent kinases independently from p53 in B16 murine melanoma cells.  Biochem. Biophys. Res. Commun. 233:678-680; 1997.

 

  1. Arany, I., C.M. Fleischmann, K. Tyring, and W.R. Fleischmann, Jr. Lack of mda‑6/WAF1/CIP1-mediated inhibition of cyclin-dependent kinases in interferon a resistant murine B16 melanoma cells. Cancer Lett. 119:237-240; 1997.

 

  1. Arany, I., T. Evans, and K. Tyring. Tissue-specific HPV expression and downregulation of local immune responses in condylomas from HIV-seropositive individuals. Sex. Transm. Inf. Dis. 74:349-353; 1998.

 

  1. Arany, I., K. Adler-Storthz, Z. Chen, K. Tyring, and M.M. Brysk. Tumor differentiation-dependent local immunity in human head and neck cancers. Cancer Lett. 123:173-176; 1998.

 

  1. Arany, I., K. Tyring, H. Brysk, and M.M. Brysk. Induction by interferon gamma of its receptor varies with epithelial differentiation and cell type. Arch. Dermatol. Res. 290:331-334; 1998.

 

  1. Horikoshi, T., J. Page, G. Lei, H. Brysk, I. Arany, K. Tyring, and M.M. Brysk. Proteasomal Rnase activity in human epidermis. In Vivo 12:155-158; 1998.

 

  1. Brysk, M.M., G. Lei, K. Adler-Storthz, Z. Chen, T. Horikoshi, H. Brysk, K. Tyring, and I. Arany. Differentiation and cathepsin D expression in human oral tumors. Laryngoscope 108:1234-1237; 1998.

 

  1. Lei G, I. Arany, K. Tyring, H. Brysk, and M.M. Brysk. Zinc-a2-glycoprotein has ribonuclease activity. Arch. Biochem. Biophys. 355:160-164; 1998.

 

  1. Brysk, M.M., G. Lei, K. Adler-Storthz, Z. Chen, H. Brysk, K. Tyring, and I. Arany. Zinc-a2-glycoprotein expression as a marker of differentiation in human oral tumors. Cancer Lett. 137:117-120; 1999.

 

  1. Horikoshi T, I. Arany, S. Rajaraman, S-H. Chen, H. Brysk, G. Lei, K. Tyring, and M.M. Brysk. Isoforms of cathepsin D and human epidermal differentiation. Biochimie 80:605-612; 1998.

 

  1. Wang, S., K. Tyring, C.M. Townsend, Jr., and B.M. Evers. Interferon-mediated activation of the STAT-signaling pathway in a human carcinoid tumor. Ann. Surg. Oncol. 5:642-649; 1998.

 

  1. Arany I, K. Adler-Storthz, Z. Chen, K. Tyring, H. Brysk, and M.M. Brysk. Local inflammation may influence oral tumor cell differentiation. Anticancer Res. 19:1065-1068; 1999.

 

  1. Lei, G, H. Brysk, I. Arany, K. Tyring, G. Srinivasan, and M.M. Brysk. Characterization of zinc- a2-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line. J. Cell Biochem. 75:160-169; 1999.

 

  1. Hudnall, S.D., P.L. Rady, K. Tyring, and J.C. Fish. Hydrocortisone activation of human herpesvirus 8 viral DNA replication and gene expression in vitro. Transplantation 67:648-652; 1999.

 

  1. Chen S-H, I. Arany, J. Apisarnthanarax, K. Tyring, S. Rajaraman, T. Horikoshi, H. Brysk, and M.M. Brysk. Response of keratinocytes from normal and psoriatic epidermis to interferon-g differs in the expression of zinc- a2-glycoprotein and cathepsin D. FASEB J. 14:565-571; 2000.

 

  1. Matalon, R., P.L. Rady, K.A. Platt, H.B. Skinner, M.J. Quast, G.A. Campbell, K. Matalon, J.D. Ceci, K. Tyring, M. Nehls, S. Surendran, J. Wei, E.L. Ezell, and S. Szucs. Knockout mouse for Canavan disease: a model for gene transfer to the central nervous system. J. Gene Med. 2:165-175; 2000.

 

  1. He N., H. Brysk, K. Tyring, I. Ohkubo, and M.M. Brysk. Zinc alpha 2 – glycoprotein hinders cell proliferation and reduces cdc2 expression. J Cell Biochem. 36 (Suppl): 162-169; 2001.

 

  1. Arany, I., K. G. Grattendick, and K. Tyring. Interleukin-10 induces transcription of the early promoter of human papillomavirus type 16 through the 5’-segment of the upper regulatory region.  Antiviral Res  55:331-339;2002.

 

  1. Surendran, S., K.A. Sacksteder, S.J. Gould, J.G. Coldwell, P.L. Rady, K. Tyring, and R. Matalon. Malonyl CoA decarboxylase deficiency: C to T transition in intron 2 of the MCD gene.  J. Neuroscience Research  65:591-594; 2001.

 

  1. Arany, I., W.E. Whitehead, K.J. Grattendick, and K. Tyring. Suppression of growth by all-trans retinoic acid requires prolonged induction of interferon regulatory factor 1 in cervical squamous carcinoma (SiHa) cells.  Clin Diagn Lab Immunol  9:  1102-1106; 2002.

 

  1. Arany, I., I.A. Ember, and K. Tyring. All-trans-retinoic acid activates caspase-1 in a dose-dependent manner in cervical squamous carcinoma cells.  Anticancer Research 23: 471-473; 2003.

 

  1. Arany, I., W.E. Whitehead, I.A. Ember, and K. Tyring. Dose-dependent  activation of p21WAF1transcription by all-trans-retinoic acid in cervical squamous carcinoma cells.  Anticancer Research 23: 495-497; 2003.

 

  1. Arany, I., S-H Chen, Z. Chen, J. Megyesi, S. Rajaraman, K. Adler-Storthz, I.A. Ember, K. Tyring, and M.M. Brysk. Differentiation-dependent expression of signal transducers and activators of transcription-3 (STAT3) in the cancers of the head and neck.  Cancer Lett 199: 83-89; 2003.

 

  1. Arany, I., K.J. Grattendick, W.E. Whitehead, I.A. Ember, and K. Tyring. A functional interferon regulatory factor-1 (IRF-1) binding site in the upstream regulatory region of the human papillomavirus type 16.  Virology  310: 280-286; 2003.

 

  1. Matalon, R., S. Surendran, P.L. Rady, M.J. Quast, G.A. Cambell, K.M. Matalon, K. Tyring, J. Wei, C.S. Peden, E.L. Ezell, N. Muzyczka, and R.J. Mandel. Adeno-associated virus mediated aspartoacylase gene transfer to the brain of knock out mouse for Canavan disease.  Mol Ther 7: 580-587; 2003.

 

  1. Matalon, R., S. Surendran, K.M. Matalon, K. Tyring, M. Quast, W. Jinga, E. Ezell and S. Szucs. Future role of large neutral amino acids in transport of phenylalanine into the brain. Pediatrics 112: 1570-1574; 2003.

 

  1. Surendran, S., G.A. Campbell, K. Tyring, K. Matalon, J.D. McDonald and R. Matalon. High levels of orexin A in the brain of the mouse model for phenylketonuria: possible role of orexin A in hyperactivity seen in children with PKU. Neurochem. Res. 28: 1891-1894; 2003.

 

  1. Surendran, S., K.M. Matalon, S. Szucs, K. Tyring and R. Matalon. Metabolic changes in the knockout mouse for Canavan’s disease: implications for patients with Canavan’s disease. J. Child. Neurol 18: 611-615; 2003.

 

  1. Surendran, S., K.M. Matalon, K. Tyring and R. Matalon. Molecular basis of Canavan’s disease: from human to mouse. J. Child. Neurol. 18: 604-610; 2003.

 

  1. Surendran, S., K. Michals-Matalon, M.J. Quast, K. Tyring, J. Wei, E.L. Ezell and R. Matalon. Canavan disease: a monogenic trait with complex genomic interaction. Mol. Genet. Metab. 80: 74-80; 2003.

 

  1. Surendran, S., P.L. Rady, K. Michals-Matalon, M.J. Quast, K.K. Rassin, G.A. Campbell, E.L. Ezell, K. Tyring, S. Szucs and R. Matalon. Expression of glutamate transporter, GABRA6, serine proteinase inhibitor and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease. Brain Res. Bull. 61: 427-435; 2003.

 

  1. Tu, H., T. Juelich, E.M. Smith, K. Tyring, P.L. Rady and T.K. Hughes Jr. Evidence for endogenous interleukin-10 during nociception. J. Neuroimmunol. 139: 145-149; 2003.

 

  1. Hudnall, S.D., T. Chen and K. Tyring. Species identification of all eight human herpesviruses with a single nested PCR assay. J. Virol. Methods 116: 19-26; 2004.

 

  1. Surendran, S., E.L. Ezell, M.J. Quast, J. Wei, K. Tyring, K. Michals-Matalon and R. Matalon. Mental retardation and hypotonia seen in the knock out mouse for Canavan disease is not due to succinate semialdehyde dehydrogenase deficiency. Neurosci. Lett. 358: 29-32; 2004.

 

  1. Li, C., Chi, N. He, X. Zhang, O. Guicherit, R. Wagner, S.K. Tyring and J. Xie. IFN alpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling. Oncogene 23: 1608-1617; 2004.

 

  1. Surendran S., P.L. Rady, S. Szucs, K. Michals-Matalon, K. Tyring and R. Matalon. High level of orexin A observed in the phenylketonuria (PKU) mouse brain is due to the abnormal expression of prepro-orexin. Biochem Biophys Res Comm 317: 522-526; 2004.

 

  1. Faluhelyi, Z., I. Rodler, A. Csejtey, K. Tyring, I.A. Ember and I. Arany. All-trans retinoic acid (ATRA) suppresses transcription of human papillomavirus type 16 (HPV 16) in a dose-dependent manner. Anticancer Res 24: 807-809; 2004.

 

  1. Surendran, S., E.L. Ezell, M.J. Quast, J. Wei, K. Tyring, K. Michals-Matalon and R. Matalon. Aspartoacylase deficiency does not affect N-acetylaspartylglutamate level or glutamate carboxypeptidase II activity in the knockout mouse brain. Brain Res 1016: 268-271; 2004.

 

  1. Surendran, S., L.S. Shihabuddin, J. Clarke, T.V. Taksir, G.R. Stewart, G. Parsons, W. Yang, K. Tyring, K. Michals-Matalon and R. Matalon. Mouse neural progenitor cells differentiate into oligodendrocytes in the brain of a knockout mouse model of Canavan disease. Brain Res Dev Brain Res. 153: 19-27; 2004.

 

  1. Tu, H., P.L. Rady, T. Jeulich, E.M. Smith, K. Tyring and T.K. Hughes. Cytokine regulation of tryptophan metabolism in the hypothalamic-pituitary-adrenal (HPA) axis: Implications for protective and toxic consequences in neuroendocrine regulation. Cell Mol Neurobiol 25: 673-680; 2005.

 

  1. Athar, M., C. Li, X. Tang, S. Chi, X. Zhang, A.L. Kim,K. Tyring, L. Kopelovich, J. Hebert, E.H. Epstein Jr., D.R. Bickers and J. Xie. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through induction of Fas expression and apoptosis. Cancer Res 64: 7545-7552; 2004.

 

  1. Surendran, S., G.A. Campbell, K. Tyring and R.Matalon. Aspartoacylase gene knockout results in severe vacuolation in the white matter and gray matter of the spinal cord in the mouse. Neurobiol Dis 18: 385-389; 2005.

 

  1. Surendran, S., K. Tyring and R. Matalon. Expression of calpastatin, minopontin, NIPSNAP1, rabaptin-5 and neuronatin in the phenylketonuria (PKU) mouse brain: Possible role on cognitive defect seen in PKU. Neurochem Int 46: 595-599; 2005.

 

  1. Surendran S., S. Szucs, K. Tyring and R. Matalon. Aspartoacylase gene knockout in the mouse: Impact on reproduction. Reprod Toxicol 20: 281-283; 2005.

 

  1. Surendran S., D. Matalon, K. Tyring, P.L. Rady, G.V. Velagaleti and R. Matalon. Altered expression of myocilin in the brain of a mouse model for phenylketonuria (PKU). Neurosci Lett 382: 323-326; 2005.

 

  1. Matalon R., S. Surendran, J.D. McDonald, O. Okorodudu, K. Tyring, K. Michals-Matalon and P. Harris. Abnormal expression of genes associated with development and inflammation in the heart of mouse maternal phenylketonuria offspring. Int J Immunopathol Pharmacol 18: 557-565; 2005.

 

  1. Koldzic-Zivanovic N., H. Tu, T.L. Juelich, P.L. Rady, K. Tyring, S.D. Hudnall, E.M. Smith and T.K. Hughes. Regulation of adrenal glucocorticoid synthesis by interleukin-10: A preponderance of IL-10 receptor in the adrenal zona fasciculata. Brain Behav. Immun. 2005.

 

  1. Matalon R., K. Michals-Matalon, S. Surendran and K. Tyring. Canavan disease: studies on the knockout mouse. Adv Exp Med Biol 576: 77-93; 2006.

 

  1. Ledeen, R.W., J. Wang, G. Wu, Z.H. Lu, G. Chakraborty, M. Meyenhofer, K. Tyring and R. Matalon. Physiological role of N-acetylaspartate: contribution to myelinogenesis. Adv Exp Med Biol. 576: 131-143; 2006.

 

  1. Surendran, S. R. Matalon and K. Tyring. Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy. Biochem Biophys Res Commun. 345: 973-975; 2006.

 

  1. Matalon, R., S. Surendran, G.A. Campbell, K. Michals-Matalon, K. Tyring, J. Grady, S. Cheng and E. Kaye. Hyaluronidase increases the biodistribution of acid alpha-1,4 glucosidase in the muscle of Pompe disease mice: an approach to enhance the efficacy of enzyme replacement therapy. Biochem. Biophys. Res. Commun. 350: 783-787; 2006.

 

  1. Tu, H., P.L. Rady, T. Juelich, K. Tyring, N. Koldzic-Zivanovic, E.M. Smith and T.K. Hughes. Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Cell Mol Neurobiol. 27: 161-170; 2007.

 

  1. Gohma, H., T. Kuramoto, R. Matalon, S. Surendran, Tyring, K. Kitada, M. Sasa, T. Serikawa. Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice. Exp Anim. 56: 161-165; 2007.

 

  1. Tyring, S.K. Sinecatechins: Effects on HPV-Induced Enzymes Involved in Inflammatory Mediator Generation. J Clin Aesthet Dermatol. 5:19-26; 2012.

 

  1. Tyring, S.K. Effect of sinecatechins on HPV-activated cell growth and induction of apoptosis. J Clin Aesthet Dermatol. 5: 34-41; 2012.

 

  1. Nguyen, H.P., A. Patel, R.A. Simonette, P. Rady and K. Tyring. Binding of the trichodysplasia spinulosa-associated polyomavirus small T antigen to protein phosphatase 2A: elucidation of a potential pathogenic mechanism in a rare skin disease. JAMA Dermatol. 150: 1234-1236; 2014.

 

  1. Wu, J.H., R.A. Simonette, T. Hsiao, D.Q.Doan, P.L.Rady and K. Tyring. Cutaneous Human Polyomavirus Small T Antigens and 4E-BP1 Targeting.

Intervirology. 58:382-385; 2015.

 

  1. Wu, J.H., R.A. Simonette, H.P. Nguyen, P.L. Rady and K. Tyring. Small T-antigen of the TS-associated polyomavirus activates factors implicated in the MAPK pathway. J Eur Acad Dermatol Venereol 30:1061-1062; 2016.

 

  1. WuH., R.A. Simonette, H.P. Nguyen, H.Q. Doan, P.L. Rady and S.K. Tyring. Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses. J Clin Virol. 76:40-43; 2016.

 

  1. Wang J, C. Dupuis, K.Tyring and M.P.Underbrink. Sterile α motif domain containing 9 is a novel cellular interacting partner to low-risk type human papillomavirus E6 proteins. PLoS One 11:e0149859; 2016.

 

  1. Underbrink, M.P., C. Dupuis, J. Wang and K. Tyring. E6 proteins from low risk human papillomavirus types 6 and 11 are able to protect keratinocytes from apoptosis via Bak degradation. J Gen Virol 97:715-724; 2016.

 

 

  1. Wu, J.H., R.A. Simonette, H.P. Nguyen, P.L. Rady and K. Tyring. Merkel cell polyomavirus in Merkel cell carcinogenesis: small T antigen-mediates c-Jun phosphorylation. Virus Genes 52:397-399; 2016.

 

  1. Wu, J.H., R.A. Simonette, H.P.Nguyen, P.L. Rady and S.K.Tyring.

Molecular mechanisms supporting a pathogenic role for human polyomavirus 6 small T antigen: Protein phosphatase 2A targeting and MAPK cascade activation.  J Med Virol. 89:742-747; 2017.

 

  1. Wu, J.H., D. Narayanan, R.A. Simonette, P.L. Rady and K. Tyring. Dysregulation of the MEK/ERK/MNK1 signaling cascade by middle T antigen of the trichoydsplasia spinulosa polyomavirus. J Eur Acad Dermatol Venereol. 2017 May 13. doi: 10.1111/jdv.14326.

 

 

 

 

  1. COMBINED BASIC AND CLINICAL RESEARCH

 

  1. Cauda, R., K. Tyring, C.E. Grossi, A.B. Tilden, K.D. Hatch, W.M. Sams, Jr., S. Baron, and R.J. Whitley. Patients with condyloma acuminatum exhibit decreased interleukin 2 and interferon gamma production and depressed natural killer activity. J. Clin. Immunol. 7:304-311; 1987.

 

  1. Tyring, S.K., R. Cauda, V. Ghanta, and R. Hiramoto. Activation of natural killer cell function during interferon-a treatment of patients with condyloma acuminatum is predictive of clinical response. Biol. Regul. Homeost. Agents 2:29-32; 1988.

 

  1. Cauda, R., K. Tyring, E. Tamburrini, G. Ventura, M. Tumbarello, and L. Ortona. Diminished interferon gamma production may be the earliest indicator of infection with the human immunodeficiency virus. Viral Immunol. 1:247-258; 1988.

 

  1. Tyring, S.K., P.C. Lee, P. Walsh, J.F. Garner, and W.P. Little. Papular protothecosis of the chest: Immunologic evaluation and treatment with a combination of oral tetracycline and topical amphotericin B. Dermatol. 125:1249-1252; 1989.

 

  1. Tyring, S.K., V. Chopra, L. Johnson, and J.D. Fine. Natural killer cell activity is reduced in patients with severe forms of inherited epidermolysis bullosa. Dermatol. 125:797-800; 1989.

 

  1. Plott, R.T., R.F. Wagner, and K. Tyring. Iatrogenic contamination of multidose vials in simulated use: A reassessment of current patient injection technique. Arch. Dermatol. 126:1441-1444; 1990.

 

  1. Chopra, V., K. Tyring, L. Johnson, and J.D. Fine. Patients with severe forms of inherited epidermolysis bullosa exhibit decreased lymphokine and monokine production. J. Clin. Immunol.10 : 321-329 ; 1990.

 

  1. Vaidya, S., K. Tyring, M. Feldkamp, L. Johnson, and J.D. Fine. HLA and epidermolysis bullosa: Lack of linkage between HLA complex and Weber-Cockayne subtype of epidermolysis bullosa. J. Dermatol. Sci. 2:155-160; 1991.

 

  1. Vaidya, S., K. Tyring, L.B. Johnson, and J.D. Fine. HLA and epidermolysis bullosa: Association between the HLA complex and recessive dystrophic epidermolysis bullosa. Arch. Dermatol. 127:1524-1527; 1991.

 

  1. Meyer, L.M., K. Tyring, and W.P. Little. Proliferating verrucous cyst. Arch. Dermatol. 127:1810-1812; 1991.

 

  1. Chopra, V., and K. Tyring. Suppression of interleukin-2 production and interleukin-2 activity by factor(s) released by peripheral blood mononuclear cells during papillomavirus infections. Viral Immunol. 4:237-248; 1991.

 

  1. Chopra, V., A. Chopra, and K. Tyring. Purification and partial characterization of a soluble suppressor factor from papillomavirus-infected patients. Viral Immunol. 4:249-258; 1991.

 

  1. Chopra, V., K. Tyring, L. Johnson, and J.D. Fine. Peripheral blood mononuclear cell subsets in patients with severe inherited forms of epidermolysis bullosa. Arch Dermatol. 128:201-209; 1992.

 

  1. Cohen, L.M., K. Tyring, P. Rady, and J.P. Callen. Human papillomavirus type 11 in multiple squamous cell carcinomas in a patient with subacute cutaneous lupus erythematosus. J. Am. Acad. Dermatol. 26:840-845; 1992.

 

  1. Zemtsov, A., K. Tyring, W. Koss, P. Rady, and L. Dixon. Anal verrucous carcinoma associated with HPV 11: MRI and flow cytometry evaluation. Arch. Dermatol. 128:564-565; 1992.

 

  1. Scinicariello, F., P. Rady, D. Saltzstein, E. Orihuela, and K. Tyring. Human papillomavirus 16 exhibits a similar integration pattern in primary squamous cell carcinoma of the penis and in its metastasis. Cancer 70:2143-2148; 1992.

 

  1. Evers, B.M., P. Rady, K. Tyring, R.L. Sanchez, S. Rajaraman, C.M. Townsend, and J.C. Thompson. Amplification of the HER-2/neu protooncogene in human endocrine tumors. Surgery 112:211-218; 1992.

 

  1. Scinicariello, F., T. Sato, C.S. Lee, H.C. Hsu, T.S. Chan, and K. Tyring. Detection of human papillomavirus in primary hepatocellular carcinoma. Anticancer Res. 12:757-762; 1992.

 

  1. Scinicariello, F., P. Rady, E. Hannigan, T.V. Dinh, and K. Tyring. Human papillomavirus type 16 in primary transitional cell carcinoma of the Bartholin’s gland and in a lymph node metastasis. Gynecol. Oncol. 47:263-266; 1992.

 

  1. Payne, D., Tyring, M. Doherty, D. Daya, and T.S. Chan. Detection of human papillomavirus type 16 in plasma cells. Gynecol. Oncol. 48:406-412; 1993.

 

  1. Brown, D.R., J.T. Bryan, K. Wools, M. Rodriquez, and K. Tyring. Detection of human papillomavirus L1 protein in condylomata acuminata from adults with defects in cell mediated immunity. J. Med. Virol. 41:79-84; 1993.

 

  1. Bonnez, W., C. Da Rin, R.C. Rose, K. Tyring, and R.C. Reichman. Evolution of the antibody response to human papillomavirus type 11 (HPV 11) in patients with condyloma acuminatum according to treatment response. J. Med. Virol. 39:340-344; 1993.

 

  1. Saltzstein, D.R., E. Orihuela, J.N. Kocurek, D.A. Payne, T.S. Chan, and K. Tyring. Failure of the polymerase chain reaction to detect human papillomavirus in transitional cell carcinoma of the bladder. Anticancer Res. 13:423-426; 1993.

 

  1. Martin, R.W., P. Rady, I. Arany, and K. Tyring. Benign Leydig cell tumor of the testis associated with human papillomavirus 33 presenting with the sign of Leser-Trelat. J. Urol. 150:1246-1250; 1993.

 

  1. Arany, I., P.L. Rady, and K. Tyring. Alterations in cytokine/antioncogene expression in skin lesions by “low risk” types of human papillomaviruses. Viral Immunol. 6:255-265; 1993.

 

  1. Tschen, J.A., K. Tyring, and R.L. Font. Paramyxovirus-like inclusions in an intradermal nevus from a healthy woman. Am. J. Dermatopathol. 16:422-425, 1994.

 

  1. Arany, I., P. Rady, B.M. Evers, K. Tyring, and C.M. Townsend, Jr. Analysis of multiple molecular changes in human endocrine tumors. Surg. Oncol. 3:153-159; 1994.

 

  1. Evers, B.M., P.L. Rady, K. Sandoval, I. Arany, K. Tyring, R.L. Sanchez, W.H.Nealon, C.M. Townsend, Jr., and J.C. Thompson. Gastrinomas demonstrate amplification of the HER-2/neu protooncogene. Ann. Surgery. 219:596-604; 1994.

 

  1. Arany, I., P.L. Rady, and K. Tyring. Interferon treatment enhances the expression of underphosphorylated (biologically active) retinoblastoma protein in human papilloma virus infected cells through the inhibitory TGFb/IFNb cytokine pathway. Antiviral Res. 23:131-141; 1994.

 

  1. Scinicariello, F., M.J. Dolan, I. Nedelcu, K. Tyring, and J.K. Hilliard. Occurrence of human papillomavirus and p53 mutations in Kaposi’s sarcoma. Virology 203:153-157; 1994.

 

  1. Hughes, T. K., P. Cadet, P. Rady, K. Tyring, and E. M. Smith. Evidence for production and action of interleukin-10 in the pituitary cells. Cell. Molec. Neurobiol. 14:57-67; 1994.

 

  1. Hughes, T. K., R. Chin, K. Tyring, and P. Rady. Distinction of mouse interferon-alpha subtypes by PCR utilizing consensus primers and type specific oligonucleotide probes. J. Interferon Res. 14:117-120; 1994.

 

  1. El-Zein, R., P. Shaw, K. Tyring, and W. Au. Chromosomal radiosensitivity of lymphocytes from skin cancer prone patients. Mutation Res. 335:143-149; 1995.

 

  1. Arany, I., P. Rady, and K. Tyring. The effect of interferon therapy on human papillomavirus copy number in patients with condyloma acuminatum. Am. J. Med. Sci. 310:14-18; 1995.

 

  1. Orihuela, E., K. Tyring, M. Pow-Sang, S. Dozier, R. Cirelli, I. Arany, P. Rady, and R. Sanchez. Development of human papillomavirus type 16 associated squamous cell carcinoma of the scrotum in a patient with Darier’s disease treated with systemic isotretinoin. J. Urol. 153:1940-1943; 1995.

 

  1. Payne, D., and K. Tyring. Human papillomavirus (HPV) DNA in non-anogenital kerato-acanthoma and squamous cell carcinoma in HIV patients. J. Am. Acad. Dermatol. 33:1047-1049; 1995.

 

  1. Cadet, P., P.L. Rady, K. Tyring, R.B. Yandell, and T.K. Hughes. Interleukin-10 message ribonucleic acid in human placenta: Implications of a role for interleukin-10 in fetal allograft protection. Am. J. Obstet. Gynecol. 173:25-29; 1995.

 

  1. Rady, P.L., A. Yen, J.L. Rollefson, I. Orengo, S. Bruce, T.K. Hughes, and K. Tyring. Herpesvirus-like DNA sequences in non-Kaposi’s sarcoma skin lesions of transplant patients. Lancet 345:1339-1340; 1995.

 

  1. Arany, I., K. Nagamani, and K. Tyring. Interferon resistance is independent from copy numbers in benign HPV-induced lesions. Anticancer Res. 15:1003-1006; 1995.

 

  1. Rady, P.L., A. Yen, R.W. Martin, I. Nedelcu, T.K. Hughes, and K. Tyring. Herpesvirus-like DNA sequences in classic Kaposi’s sarcomas. J. Med. Virol. 47:179-183; 1995.

 

  1. Payne, D.A., T.S. Chan, B. Patten, and K. Tyring. Extrachromosomal human papillomavirus (HPV) in multiple myeloma and monoclonal gammopathy of unknown significance (MGUS) patients. Anticancer Res. 15:2213-2216; 1995.

 

  1. Arany, I., A. Goel, and K. Tyring. Interferon response depends on viral transcription in human papillomavirus-containing lesions. Anticancer Res. 15:2865-2870; 1995.

 

  1. Rady, P.L., E.M. Smith, P. Cadet, M.R. Opp, K. Tyring, and T.K. Hughes, Jr. Presence of interleukin 10 transcripts in human pituitary and hypothalamus. Cell. Mol. Neurobiol. 15:289-296; 1995.

 

  1. Payne, D., T.S. Chan, P. Rady, R. Wagner, and K. Tyring. Cloning of mucosal and cutaneous HPV sequences in metastatic squamous cell carcinoma from an epidermodysplasia verruciformis patient. Anticancer Res. 16:1165-1166; 1996.

 

  1. Payne, D.A., T.S. Chan, B.O. Schoaib, B.M. Patten, and K. Tyring. Human papillomavirus (HPV) is associated with monoclonal gammopathies of unknown significance (MGUS). J. Biomed. Sci. 3:319-322; 1996.

 

  1. Payne, D.A., K. Tyring, S. Kumar, B.M. Patten, B. Ostermeyer Shoaib, and T.S. Chan. Human papillomaviruses (HPV) are associated with multiple myeloma. Internat. J. Oncology 9:345-349; 1996.

 

  1. Arany, I., and K. Tyring. Activation of local cell-mediated immunity in interferon responsive patients with human papillomavirus-associated lesions. J. Interferon and Cytokine Res. 16:453-460; 1996.

 

  1. Arany, I., and K. Tyring. Status of local cellular immunity in interferon responsive and nonresponsive human papillomavirus-associated lesions. Sexual. Transm. Dis. 23 :475-480 ; 1996.

 

  1. Arany, I., M.M. Brysk, H. Brysk, and K. Tyring. Response to interferon treatment decreases with epidermal dedifferentiation in condylomas. Antivir. Res. 32:19-26; 1996.

 

  1. Ratoosh, S., A.P. Glombicki, S.G. Lockhart, P. Rady, R. Chin, I. Arany, T.K. Hughes, and K. Tyring. Mastication of verruca vulgaris associated with esophageal papilloma: HPV-45 sequences detected in oral and cutaneous tissues. J. Am. Acad. Dermatol. 36:853-857; 1997.

 

  1. Maurer, T.A., K.V. Christian, R.Z. Kershmann, B. Berzin, J.M. Palefsky, D. Payne, K. Tyring, and T.G. Berger. Cutaneous squamous cell carcinoma in human immunodeficiency virus-infected patients – A study of epidemiologic risk factors and detection of human papillomavirus and p53 expression. Arch. Dermatol. 133:577-583; 1997.

 

  1. Arany, I., A. Yen, and K. Tyring. P53, WAF1/CIP1 and mdm 2 expression in skin lesions associated with human papillomavirus and human immunodeficiency virus. Anticancer Res. 17:1281-1285; 1997.

 

  1. Cortez-Franco, R., K. Tyring, E. Vega, D. Payne, J. Granados, and L. Dominquez-Soto. Divergent clinical course of epidermodysplasia verruciformis in siblings. Int. J. Dermatol. 36:435-452; 1997.

 

  1. Yan J., K. Tyring, M.M. McCrary, P.C. Lee, S. Haworth, R. Raymond, S.J. Olson, and R.B. Diasio. The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster. Clin. Pharmacol. Ther. 61:563-573; 1997.

 

  1. Colomé-Grimmer, M.I., D.A. Payne, K. Tyring, and R.L. Sánchez. Borrelia burgdorferi and Borrelia hermsii DNA are not associated with morphea or lichen sclerosus et atrophicus in the Southwestern United States. Arch. Dermatol. 133:1174; 1997.

 

  1. Yen, A., P.L. Rady, R. Cortes-Franco, and K. Tyring. Detection of Mycobacterium tuberculosis in erythema induratum of Bazin using polymerase chain reaction. Arch. Dermatol. 133:532-533; 1997.

 

  1. Memar, O.M., P.L. Rady, R.M. Goldblum, A. Yen, and K. Tyring. Human herpesvirus 8 DNA sequences in blistering skin from patients with pemphigus.  Arch. Dermatol. 133:1247-1251; 1997.

 

  1. Scheel, M.M., P.L. Rady, K. Tyring, and A.G. Pandya. Sinus histocytosis with massive lymphadenopathy.  Presentation as giant granuloma annulare and detection of human herpesvirus 6.  J. Am. Acad. Dermatol. 37:643-646; 1997.

 

  1. Burdick, A.E., C. Carmichael, P.L. Rady, K. Tyring, and E. Badiavas. Resolution of Kaposi’s sarcoma associated with undetectable level of human herpesvirus 8 DNA in an AIDS patient following protease inhibitor therapy.  J. Am. Acad. Dermatol. 37:648-649; 1997.

 

  1. Gaspari, A.A., S. Marchese, D. Powell, P.L. Rady, and K. Tyring. Identification of HHV-8 DNA in the skin lesions of Kaposi’s sarcoma in an immunocompromised patient with bullous pemphigoid.  J. Am. Acad. Dermatol. 37:843-847; 1997.

 

  1. Gaspari, A.A., A.D. Zalka, D. Payne, M. Menegus, L.A. Bunce, C.N. Abboud, and K. Tyring. Successful treatment of a generalized human papillomavirus infection with granulocyte-macrophage colony-stimulating factor and interferon gamma immunotherapy in a patient with a primary immunodeficiency and cyclic neutropenia. Arch. Dermatol. 133:491-496; 1997.

 

  1. Arany, I., K. Adler-Storthz, K. Tyring, H. Brysk, and M.M. Brysk. Differentiation markers in oral carcinomas and cell lines. Anticancer Res. 17:4607-4610; 1997.

 

  1. Kumar, D., S. Kumar, D. Payne, K. Tyring, and T.V. Dihn. Synchronous endometrial and endocervical adenocarcinoma. Int. J. Gynecol. 7:466-470; 1997.

 

  1. Hudnall, S.D., P.L. Rady, K. Tyring, and J.C. Fish. Serologic and molecular evidence of human herpesvirus 8 activation in renal transplant patients. J. Infect. Dis. 178 :1791-1794 ; 1998.

 

  1. Rassekh, C.H., P.L. Rady, I. Arany, K. Tyring, S. Knudsen, K.H. Calhoun, H. Seikaly, and B.J. Bailey. Combined EBV and HPV infection in nasopharyngeal carcinomas. Laryngoscope 108:362-367; 1998.

 

  1. Arany, I., and K. Tyring. Systemic immunosuppression by HIV infection influences HPV transcription and thus local immune responses in condyloma acuminatum. Int. J. STD and AIDS 9:268-271; 1998.

 

  1. Arany, I., and K. Tyring. Status of cytokine and antigen presentation genes in Merkel cell carcinomas of the skin.  J. Cut. Med. Surg. 2:138-141; 1998.

 

  1. Tyring, S.K., I. Arany, M.A. Stanley, M.A. Tomai, R.L. Miller, M.H. Smith, D.J. McDermott, and H.B. Slade. A molecular study of condylomata acuminata clearance during treatment with imiquimod: A randomized, double blind, vehicle-controlled study. Infect. Dis. 178 :551-555 ; 1998.

 

  1. Bryan, J.T., M.H. Stoler, K. Tyring, T. McClowrey, K.H. Fife, and D.R. Brown. High-grade dysplasia in genital warts from patients infected with the human immunodeficiency virus. J. Med. Virol. 54:69-73; 1998.

 

  1. Rady, P.L., V.J. Schnadig, R.L. Weiss, T.K. Hughes, and K. Tyring. Malignant transformation of recurrent respiratory papillomatosis associated with integrated HPV-11 DNA and mutation of p53. Laryngoscope 108:735-740; 1998.

 

  1. Rady, P.L., E. Hodak, A. Yen, O. Memar, A. Trattner, M. Feinmesser, M. David, S.D. Hudnall, and K. Tyring. Detection of human herpesvirus 8 DNA in Kaposi’s sarcomas from iatrogenically immunosuppressed patients. J. Am. Acad. Dermatol. 38:429-437; 1998.

 

  1. Arany, I., K. Tyring, M.A. Stanley, M.A. Tomai, R.L. Miller, M.N. Smith, D.J. McDermott, and H.B. Slade. Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5%.  Antiviral Res. 43:55-63; 1999.

 

  1. Zong, J.C., D.M. Ciufo, D.J. Alcendor, X. Wan, J. Nichols, P. Browning, P. Rady, K. Tyring, J. Orenstein, C. Rabkin, I.J. Su, K.F. Powell, M. Croxson, K. Foreman, B. Nickoloff, S. Alkan, and G.S. Hayward. High level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi’s sarcoma associated herpesvirus (HHV8) genome defines four major virus subtypes and multiple variants or clades in different human populations. J. Virol. 73:4156-4170; 1999.

 

  1. Arany, I., M.M. Brysk, Z. Chen, K. Adler-Storthz, and K. Tyring. Differentiation-dependent expression of growth regulatory cytokines and their receptors in squamous cell carcinomas of the head and neck.  Anticancer Res 19:3623-3626; 1999.

 

  1. Schell, B., T., Rosen, P. Rady, I. Arany, M. Mack, and K. Tyring. Verrucous carcinoma of the foot associated with human papillomavirus type 16. J. Am. Acad. Dermatol. 45: 49-55; 2001.

 

  1. Rady, P.L., K. Tyring, D.S. Hudnall, T. Vargas, L.H. Kellner, H. Nitowsky, and R. Matalon. Methylene-tetrahydrofolate reductase (MTHFR): The incidence of mutations C677T and A1298c in the Ashkenazi Jewish population. Am. J. Med. Genet. 8:380-384; 1999.

 

  1. Payne, D.A., S. Mehta, K. Tyring, R.P. Stowe, and D. Pierson. Incidence of Epstein Barr virus in astronaut saliva during spaceflight. Space, Aviation and Environmental Medicine 70:1211-1213; 1999.

 

  1. Rady, P. L., R. Matalon, T. Vargas, K. Tyring, and U. Langenbeck. Novel missense mutation (Y231C) in a Turkish patient with Canavan disease. Am. J. Med. Genet.  87(3): 273-275; 1999.

 

  1. Yen-Moore, A., S.D. Hudnall, P.L. Rady, R.F.Wagner, T.O. Moore, O. Memar, T.K. Hughes, and K. Tyring. Differential expression of the HHV-8 vGCR cellular homolog gene in AIDS-associated and classic Kaposi’s Sarcoma: Potential role of HIV-1 Tat. Virology 267:247-251; 2000.

 

  1. Arany I., K. Tyring, M.M. Brysk, M.A. Stanley, M.A. Tomai, R.L. Miller, M.H. Smith, D.J. McDermott, and H.B. Slade. Correlation between pretreatment levels of interferon response genes and clinical responses to an immune response modifier (Imiquimod) in genital warts. Antimicrobial Agents and Chemotherapy. 44: (7) 1869-1873; 2000.

 

  1. Mehta, S.K., R.P. Stowe, A.H. Feiveson, K. Tyring, and D.L. Pierson. Reactivation and shedding of Cytomegalovirus in astronauts during spaceflight.  J. Infect. Dis.  182: 1761-1764; 2000.

 

  1. Rady, P. L., M. J. Penzien, T. Vargas, S K. Tyring, and R. Matalon. Novel splice site mutation of aspartoacylase gene in a Turkish patient with Canavan disease. J. Pediat. Neurol. 4: 27-30; 2000.

 

  1. Arany, I., M. Muldrow, and K. Tyring. The endogenous interferon system in anal squamous epithelial lesions with different grades from HIV-positive individuals.  Int J STD AIDS 12: 229-233; 2001.

 

  1. Arany, I., M. Muldrow, and K. Tyring. Correlation between mRNA levels of IL-6 and TNF a and progression rate in anal squamous epithelial lesions from HIV positive men.  Anticancer Res 21: 425-428; 2001.

 

  1. Stetson, C.L., R.P. Rapini, K. Tyring, and R.C. Kimbrough. CD4+ lymphocytopenia with disseminated HPV J. Cutan. Pathol. 29: 502-505; 2002.

 

  1. Rady, P.L., S. Szucs, J. Grady, S.D. Hudnall, L.H. Kellner, H. Nitowsky, K. Tyring, and R.K. Matalon. Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A.  Am. J. Med. Genetics 107: 162-168; 2002..

 

  1. Arrastia, C.D., S.C. Robazetti, T.V. Dinh, Z. Gatalica, S.K. Tyring, and E.V. Hanigan. Clinical and molecular responses in high grade intraepithelial neoplasia treated with topical imiquimod 5%.  Cancer Res.  7: 30331-3033; 2001.

 

  1. Dianzani, F., G. Antonnelli, K. Tyring, D. Carrasco, D. Nguyen, J. Pan, J. Poast, M. Cloyd, and S. Baron. The HIV RNA load in chronically infected patients circulates mainly as neutralized immune complexes.  J. Infect. Dis. 185: 1051-1054; 2002.

 

  1. Zong, J., D.M. Ciufo, R. Viscidi, L. Alagiozoglou, Tyring, P. Rady, J. Orenstein, W. Boto, H. Kalumbuja, N. Romano, M. Melbye, G.H. Kang, C. Boshoff, and G.S. Hayward. Genotypic analysis at multiple loci across Kaposi’s sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism.  J. Clin. Virol.  23(3): 119-48; 2002.

 

  1. Patera, A., M.A. Ali, K. Tyring, T. Warren, P. Hohman, E.Yu, and J. Cohen. Polymorphisms in the genes for herpesvirus entry.  J. Infect. Dis.  186(3): 444-445; 2002.

 

  1. Chen, J., L. Wang, J.J. Chen, G.K. Sahu, K. Tyring, K. Ramsey, A.J. Indrikovs, J.R. Petersen, D. Paar, and M.W. Cloyd. Detection of antibodies to human immunodeficiency virus (HIV) that recognize conformational epitopes of glycoproteins 160 and 41 often allows for early diagnosis of HIV infection.  J. Infect. Dis. 186(3): 321-331; 2002.

 

  1. Roncalli, W., S. Carrasco, C.F. Neto, P.L. Rady, and K. Tyring. Nonspecific cell-mediated immunity in epidermodysplasia verruciformis.  J. Dermatol 30: 203-209; 2003.

 

  1. Roncalli, W., C.F. Neto, P.L. Rady, and K. Tyring. Seborrheic keratosis-like lesions in patients with epidermodysplasia verruciformis.  J. Dermatol 30: 48-53; 2003.

 

  1. Roncalli, W., C.F. Neto, P.L. Rady, and K. Tyring. Clinical aspects of epidermodysplasia verruciformis.  J. Eur. Acad. Venereol. 17: 394-398; 2003.

 

  1. Rady, P.L., S. Surendran, A.T. Vu, J.C. Hawkins, K. Michals-Matalon, K. Tyring, J. Merren, A.K. Kumar, and R.K. Matalon.  Founder mutation, R 245H, of Sanfilippo syndrome type A in the Cayman Islands.  Genetic Testing 6: 211-215; 2002.

 

  1. Surendran S., K. Michals-Matalon, S. Krywawych, Q.H. Qazi, R. Tuchman, P.L. Rady, K. Tyring, and R. Matalon, DOOR syndrome:  Deficiency of E1 component of the 2-oxoglutarate dehydrogenase complex.  Am. J. Med. Genetics 113: 371-374; 2002.

 

  1. Hudnall, S.D., T. Chen, P. Rady, K. Tyring, and P. Allison. Human herpesvirus 8 seroprevalence and viral load from southeast Texas blood donors.  Transfusion 43: 85-90; 2003.

 

  1. Sierra-Torres, C. H., W. Au, C. Arrastia, N. Cajas-Salazar, S. Robazetti, D. Payne, and K. Tyring. Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia.  Environ. Mol. Mutagen. 41: 69-76; 2003.

 

  1. Sierra-Torres, C.H., K. Tyring, and W. Au. Risk contribution of sexual behavior and cigarette smoking to cervical neoplasia. Int. J. Gynecol. Cancer 13: 617-625; 2003.

 

  1. Hudnall, S.D., T. Chen, K. Brown, T. Angel, M. Schwartz and K. Tyring. Human herpesvirus 8 positive microvenular hemangioma in POEMS syndrome. Arch. Pathol. Lab. Med. 127: 1034-1036; 2003.

 

  1. Cajas-Salazar, N., W. Au, J. B. Zwishcenberger, C.H. Sierra-Torres, S.A. Salama, S.K. Alpard, and K. Tyring. Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer.  Cancer Genet. Cytogenet.  145: 97-102; 2003.

 

  1. Surendran, S., F.J. Bamforth, A. Chan, K. Tyring, S.I. Goodman, and R. Matalon. Mild elevation of N-acetyl aspartic acid and macrocephaly:  a diagnostic problem.  J. Child. Neurol. 18: 809-812; 2003.

 

  1. Roncalli, W., P.L. Rady, J. Grady, T.K. Hughes, C.F. Neto, E.A. Rivitti, and K. Tyring. Polymorphisms of the interleukin-10 gene promotor in epidermodysplasia verruciformis patients from Brazil.  J. Am. Acad. Dermatol. 49: 639-643; 2003.

 

  1. Carrasco, D.A., Z Trizna, M. Colome-Grimmer, and K. Tyring. Verrucous herpes of the scrotum in a human immunodeficiency virus-positive man:  case report and review of the literature.  JEADV 16:  511-515; 2002.

 

  1. Au, W.W., C.H. Sierra-Torres and K. Tyring. Acquired and genetic susceptibility to cervical cancer. Mutat. Res. 544: 361-364. 2003.

 

  1. Matalon R., R. Koch, K. Michals-Matalon, K. Moseley, S. Surendran, K. Tyring, H. Erlandsen, A. Gamez, R.C. Stevens, A. Romstad, L.B. Moller and F. Guttler. Biopterin responsive phenylalanine hydroxylase deficiency. Genet Med 6: 27-32; 2004.

 

  1. Roncalli, W., Q. He, P.L. Rady, T.K. Hughes, C.F. Neto, E.A. Rivitti, and K. Tyring. HPV typing in Brazilian patients with epidermodysplasia verruciformis:  high prevalence of EV-HPV 25.  J. Cutan. Med. Surg. J Cutan Med Surg 8: 110-115; 2004.

 

  1. Roncalli, W., P.L. Rady, J. Grady, T.K. Hughes, C.F. Neto, E.A. Rivitti and K. Tyring. Association of p53 polymorphism with skin cancer. Int. J. Dermatol. 43: 489-493; 2004.

 

  1. Rady, P.L., R. Matalon, J. Grady, E.M. Smith, S.D. Hudnall, L.H. Kellner, H.Nitowsky, K. Tyring, and T.K. Hughes. Comprehensive analysis of genetic polymorphisms in the interleukin-10 promotor: implications for immune regulation in specific ethnic populations. Genet. Test. 8: 194-203; 2004.

 

  1. Erlandsen, H., A.L. Pey, A. Gamez, B. Perez, L.R. Desviat, C. Aguado, R. Koch, S. Surendran, Tyring, R. Matalon, C.R. Scriver, M. Ugarte, A. Martinez and R.C. Stevens. Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc Natl Acad Sci USA 101: 16903-16908; 2004.

 

  1. Fuessel Haws, A.L., Q. He, P.L. Rady, L. Zhang, J. Grady, T.K. Hughes, K. Stisser, R. Konig and K. Tyring. Nested PCR with the PGMY09/11 and GP5(+)/6(+) primer sets improves detection of HPV DNA in cervical samples. J. Virol Methods 122: 87-93; 2004.

 

 

  1. Surendran, S., K. Tyring, K. Michals-Matalon and R. Matalon. Therapeutic options in prevention and treatment of aspartoacylase gene mutation resulting abnormalities in Canavan disease. Current Pharmacogenomics 2: 13-20; 2004.

 

  1. Gonzalez, L., A.M. Gaviria, G. Sanclemente, P.L. Rady, K. Tyring, R. Carlos, L. Correa, and G. Sanchez. Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Columbia. Int. J. Dermatol 44:274-279; 2005.

 

  1. Dao, D.D., C.H. Sierra-Torres, S.C. Robazetti, M.N. de Gomez, R. Konig, J. Lester, W. Au, and K. Tyring. HLA-DQB1 and cervical cancer in Venezuelan women. Gyn Oncol 96: 349-354; 2005.

 

  1. Sra, K.K., J. Waguespack-LaBiche, R. Jordon, S. Raimer and K. Tyring. T/natural killer-cell lymphomas. J. Amer. Acad. Dermatol 52: 708-710; 2005.

 

  1. Haws, A.L., S. Woeber, M. Gomez, N. Garza, Y. Gomez, P. Rady, Q. He, L. Zhang, J.J. Grady, J.B. McCormick, S.P. Fisher-Hoch and K. Tyring. Human papillomavirus infection and p53 codon 72 genotypes in a Hispanic population at high-risk for cervical cancer. J. Med. Virol. 77: 265-272; 2005.

 

  1. Matalon, R., K. Michals-Matalon, R. Koch, J. Grady, K. Tyring and R.C. Stevens. Response of patients with phenylketonuria in the US to tetrahydrobiopterin. Mol Genet Metab. 86: 17-21; 2005.

 

  1. Chi, S., S. Huang, C. Li, X. Zhang, N. He, M.S. Bhutani, D. Jones, C.Y. Castro, R. Logrono, A. Haque, J. Zwischenberger, K. Tyring, H. Zhang and J. Xie. Activation of the hedgehog pathway in a subset of lung cancers. Cancer Lett. 244: 53-60; 2006.

 

  1. Pan, J., J. Chen, H. Lee, G.K. Sahu, J.S. Poast, K. Tyring, M. Cloyd and S. Baron. Antiviral Res. 70: 21-27; 2006.

 

  1. Lema, C., A.L. Fuessel-Haws, L.R. Lewis, P.L. Rady, P. Lee, E.A. Turbat-Herrera, Q. He, L. T. Nguyen, K. Tyring and D.D. Dao. Association between HLA-DQB1 and cervical dysplasia in Vietnamese women. Int J. Gynecol Cancer 16: 1269-1277; 2006.

 

  1. Gober, M.D., P.L. Rady, Q. He, S.B. Tucker, K. Tyring and A.A. Gaspari. Novel homozygous frameshift mutation of EVER 1 gene in an epidermodysplasia verruciformis patient. J. Invest. Dermatol. 127: 817-820; 2006.

 

  1. Mark, K.E., L. Corey, T.C. Meng, A.S. Magaret, M.L. Huang, S. Selke, H.B. Slade, K. Tyring, T. Warren, S.L. Sacks, P. Leone, V.A. Bergland, A. Wald. Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial. J Infect Dis. 195: 1324-1331; 2007.

 

  1. Michals-Matalon, K., G. Bhatia, F. Guttler, K. Tyring, R. Matalon. Response of phenylketonuria to tetrahydrobiopterin. J Nutr. 137: 1564S-1567S; 2007.

 

  1. Wang, L., S. Surendran, K. Michals-Matalon, G. Bhatia, S. Tanskley, R. Koch, J. Grady, K. Tyring, R.C. Stevens, F. Guttler, R. Matalon. Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin. Genet Test. 11: 174-178; 2007.

 

  1. Rady, P.L., W.R. De Oliveira, Q. He, C. Festa, E.A. Rivitti, S.B. Tucker, K. Tyring. Novel homozygous nonsense TMC8 mutation detected in patients with epidermodysplasia verruciformis from a Brazilian family. Br J Dermatol. 157: 831-833; 2007.

 

  1. Sanclemente, G., S. Herrera, K. Tyring, P.L. Rady, J.J. Zuleta, L.A. Correa, Q. He, J.C. Wolff. Human papillomavirus (HPV) viral load and HPV type in the clinical outcome of HIV-positive patients treated with imiquimod for anogenital warts and anal intraepithelial neoplasia. J Eur Acad Dermatol Venereol. 21: 1054-1060; 2007.

 

  1. Vu, J., G.R. Wallace, R. Singh, H. Diwan, V. Prieto, P. Rady, Tyring, M. Duvic. Common variable immunodeficiency syndrome associated with epidermodysplasia verruciformis. Am J Clin Dermatol. 8: 307-310; 2007.

 

  1. Kunishige, J.H., S.R. Hymes, V. Madkan, A.J. Wyatt, D. Uptmore, A.J. Lazar, S. Giralt, P. Rady, Tyring. Epidermodysplasia verruciformis in the setting of graft-versus-host disease. J Am Acad Dermatol. 57: S78-80; 2007.

 

  1. Mehta, S.K., K. Tyring, D.H. Gilden, R.J. Cohrs, M.J. Leal, V.A. Castro, A.H. Feiveson, C.M. Ott, D.L. Pierson. Varicella-zoster virus in the saliva of patients with herpes zoster. J Infect Dis. 197: 654-657; 2008.

 

  1. Cohen, P.R., K.E. Schulze, P.L. Rady, K. Tyring, Q. He, P.T. Martinelli, B.R. Nelson. Detection of human papillomavirus in cutaneous clear cell squamous cell carcinoma in situ: viral-associated oncogenesis may contribute to the development of this pathologic variant of skin cancer. J Cutan Pathol. 35: 513-514; 2008.

 

  1. Hudnall, S.D., T. Chen, P. Allison, K. Tyring, A. Heath. Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction. Transfusion. 48: 1180-1187; 2008.

 

  1. Rohwedder, A., H. Foong, K. Tyring, P. Rady, J.A. Carlson. Incidental epidermodysplasia verruciformis human papillomavirus infection (EV acanthoma): evidence for ‘field cancerization’ and a putative cofactor in seborrheic keratosis. J Cutan Pathol. 35: 1151-1155; 2008.

 

  1. Donaghy, H., L. Bosnjak, A.N. Harman, V. Marsden, K. Tyring, T.C. Meng, A.L. Cunningham. Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infection. J Virol. 83: 1952-1961; 2009.

 

  1. Rogers, H.D., J.L. Macgregor, K.M. Nord, Tyring, P. Rady, D.E. Engler, M.E. Grossman. Acquired epidermodysplasia verruciformis. J. Am Acad Dermatol. 60: 315-320; 2009.

 

  1. Trottier, H., S.M. Mahmud, L. Lindsay, D. Jenkins, W. Quint, S.L. Wieting, A. Schuind, E.L. Franco, GSK HPV-001 Vaccine Study Group (i.e. K. Tyring). Persistence of an incident human papillomavirus infection and timing of cervical lesions in previously unexposed young women. Cancer Epidemiol Biomarkers Prev. 18: 854-862; 2009.

 

  1. Satyaprakash, A.K., A.M. Tremaine, A.A. Stelter, R. Creed, P. Ravanfar, N. Mendoza, S.K. Mehta, P.L. Rady, D.L. Pierson, K. Tyring. Viremia in Acute Herpes Zoster. J Infect Dis. 200:26-32; 2009.

 

  1. Vidulich, K.A., P.L. Rady, Q. He, K. Tyring, M. Duvic. Detection of high-risk human papillomaviruses in verrucae of patients with mycosis fungoides and Sezary syndrome: a case series. Int J Dermatol. 48:598-602; 2009.

 

  1. Vickers, J.L., R.J. Matherne, A. W. Allison, M.G. Wilkerson, K. Tyring, B.L. Bartlett, P.L. Rady and B.C. Kelly. Transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type 11. J Cutan Pathol. 37:793-6; 2010.

 

  1. Hoshino, Y., H. Katano, P. Zou, P. Hohman, A. Marques, K. Tyring, D. Follmann and J.I.l Cohen. Long-term administration of valacyclovir reduces the number of Epstein-Barr virus (EBV)-infected B cells but not the number of EBV DNA copies per B cell in healthy volunteers. J Virol. 83:11857-11861; 2009.

 

  1. Alijahbana B., R. Dinata, E. Sutedja, I. Suryahudaya, H. Soedjana, N.N. Hidajat, R.D. Soetikno, E. Oktaliansah, A. Deng, P. Rady, K. Tyring and A.A. Gaspari. Disfiguring generalized verrucosis in an Indonesian man with idiopathic CD4 lymphopenia. Arch Dermatol. 146(1):69-73; 2010.

 

  1. Oliveira, W.R., M.N. Sotto, C. Festa, P. Rady and K. Tyring. Merkel cell polyomavirus in Merkel cell carcinoma from a Brazilian epidermodysplasia verruciformis patient. J Am Acad Dermatol.  62:889-890; 2010.

 

  1. Slodkowska, E.A., J. Schwartz, P.L. Rady, K. Tyring and J.A. Carlson. Atopic dermatitis associated with HPV 38 lower leg verrucosis.  Am J Dermatopathol.  32:610-613; 2010.

 

  1. Palm, M.D., K. Tyring, P.L. Rady and M.D. Tharp. Human papillomavirus typing of verrucae in a patient with WHIM syndrome. Arch Dermatol. 146:931-932; 2010.

 

  1. Cragun, W.C., B.L. Bartlett, M.W. Ellis, A.Z. Hoover, K. Tyring, N. Mendoza, T.J. Vento, W.L. Nicholson, M.E. Eremeeva, J.P. Olano, R.P. Rapini and C.D. Paddock. The expanding spectrum of eschar-associated rickettsioses in the United States. Arch Dermatol. 146:641-648. 2010.

 

  1. Diamantis, M.L., H.M. Richmond, P.L. Rady, K. Tyring, J.E. Cutlan, C. Torres-Cabala and S.R. Hymes. Detection of human papillomavirus in multiple eccrine poromas in a patient with chronic graft-vs-host disease and immunosuppression.  Arch Dermatol. 147:120-122; 2011.

 

  1. Pierson, D.L., S.K. Mehta, D. Gilden, R.J. Cohrs, M.A. Nagel, D.S. Schmid, and K. Tyring. Varicella zoster virus DNA at inoculation sites and in saliva after Zostavax immunization. J Infect Dis. 203:1542-1545; 2011.

 

  1. Hunt, R., C. Hwa, J. Tzu, R. Patel, K. Tyring and J. Stein. Multiple human papillomavirus-16 associated digital squamous-cell carcinomas in an immunocompetent woman with prior human papillomavirus-related genital carcinoma. Dermatol Online J. 17:20; 2011.

 

  1. Nagel, M.A., A. Choe, R.J. Cohrs, I. Traktinskiy, K. Sorensen, S.K. Mehta, D.L. Pierson, K. Tyring, K. Haitz, C. DiGiorgio, W. LaPolla and D. Gilden. Persistence of varicella zoster virus DNA in saliva after herpes zoster. J Infect Dis. 204:820-824; 2011.

 

  1. Arnold, A.W., B. Burger, E. Kump, A. Rufle, K. Tyring, W. Kempf, P. Hausermann and P.H. Itin. Homozygosity for the c.917A→T (p.N306l) polymorphism in the EVER2/TMC8 gene of two sisters with epidermodysplasia verruciformis Lewandowsky-Lutz originally described by Wilhelm Lutz. Dermatology. 222:81-86; 2011.

 

  1. Roteli-Martins, C.M., N.S. de Carvalho, P. Naud, J. Teixeira, P. Borba, S. Derchain, K. Tyring, S. Gall, A. Diaz, M. Blatter, R.M. Schier, B. Romanowski, W.G. Quint, J. Issam, C. Galindo, A. Schuind and G. Dubin. Prevalence of human papillomavirus infection and associated risk factors in young women in Brazil, Canada, and the United States: a multicenter cross-sectional study. Int J Gynecol Pathol. 30:173-184; 2011.

 

  1. Moore, R.L., V. de Schaetzen, M. Joseph, I.A. Lee, Y. Miller-Monthrope, B.R. Phelps, S.S. Lekalake, S.J. Ratcliffe, H. Nguyen, Q. He, P. Rady, K. Tyring and C.L. Kovarik. Acquired epidermodysplasia verruciformis syndrome in HIV-infected pediatric patients: prospective treatment trial with topical glycolic acid and human papillomavirus genotype characterization. Arch Dermatol. 148:128-130; 2012.

 

  1. Fisher, M.K., G.F. Kao, H.P. Nguyen, C.B. Drachenberg, P.L. Rady, K. Tyring and A.A. Gaspari. Specific Detection of Trichodysplasia Spinulosa-Associated Polyomavirus DNA in Skin and Renal Allograft Tissues in a Patient With Trichodysplasia Spinulosa. Arch Dermatol. 148: 726-733;2012.

 

  1. Tyring, S.K.,E. Stek, J.G. Smith, J. Xu, M. Pagnoni, I.S. Chan, J.L. Silber, J. Parrino and M.J. Levin. Varicella-zoster virus-specific enzyme-linked immunospot assay responses and zoster-associated pain in herpes zoster subjects. Clin Vaccine Immunol 19: 1411-1415; 2012.

 

  1. Mendoza, N., P.O. Hernandez, K. Tyring, K.A. Haitz and A. Motta. Antimicrobial susceptibility of Propionibacterium acnes isolates from acne patients in Colombia. Int J Dermatol 52: 688-692; 2013.

 

  1. Falchook G.S., P. Rady, S. Hymes, H.P. Nguyen, K. Tyring, V.G. Prieto, D.S. Hong and R. Kurzrock. Merkel cell polyomavirus and HPV-17 associated with cutaneous squamous cell carcinoma arising in a patient with melanoma treated with the BRAF inhibitor dabrafenif. JAMA Dermatol 149: 322-326; 2013.

 

  1. Mehta, S.K., K. Tyring, R. J. Cohrs, D. Gilden, A.H. Feiveson, K.J. Lechler and D.L. Pierson. Rapid and sensitive detection of varicella zoster virus in saliva of patients with herpes zoster. J Virol Methods 193: 128-130; 2013.

 

  1. Zahir, A., L. Craig, P. Rady, K. Tyring and A. Ehrlich. Epidermodysplasia verruciformis associated with HPV 10. Dermatol Online J 19: 2; 2013.

 

  1. Wanat, K.A., K. Tyring, P. Rady and C.L. Kovarik. Human papillomavirus type 27 associated with multiple verruca within a tattoo: report of a case and review of the literature. In J Dermatol 53: 882-884; 2014.

 

  1. Sagdeo, A., R.H. Gormley, K. Abuabara, K. Tyring, P. Rady, D.E. Elder and C. L. Kovarik. The diagnostic challenge of vulvar squamous cell carcinoma: Clinical manifestations and unusual human papillomavirus types. J Am Acad Dermatol 70: 586-588; 2014.

 

  1. Umanoff, N., B. Werner, P.L. Rady, K. Tyring and J.A. Carlson. Persistent toenail onycholysis associated with beta-papillomavirus infection of the nail bed. Am J Dermatopathol; 2014.

 

  1. Nguyen, H. P., H.Q. Doan, D.J. Brunell, P. Rady and K. Tyring. Apoptotic gene expression in sinecatechins-treated external genital and perianal warts. Viral Immunol 27: 556-558; 2014.

 

  1. Gormley, R.H., E.J. Kim, A.H. Rook, C.L. Kovarik, A. Sun, P. Rady and K. Tyring. Merkel cell polyomavirus in low levels in folliculotropic mycosis fungoides represents a passenger, not a driver. Int J Dermatol 54: 182-183; 2015.

 

  1. Doan, H.Q., H.P. Nguyen, P. Rady and K. Tyring. Expression patterns of immune-associated genes in external genital and perianal warts treated with sinecatechins. Viral Immunol 28: 236-240; 2015.

 

  1. Cohen, D.N., S.K. Lawson, A.C. Shaver, L. Du, H.P. Nguyen, Q. He, D.B. Johnson, W.A. Lumbang, B.R. Moody, J.L. Prescott, P.K. Chandra, A.S. Boyd, J. P. Zwerner, J.B. Robbins, K. Tyring, P.L. Rady, J.D. Chappell, Y. Shyr, J.R. Infante and J.A. Sosman. Contribution of beta-HPV infection and UV damage to rapid-onset cutaneous squamous cell carcinoma during BRAF-inhibition therapy. Clin Cancer Res 21: 2624-2634; 2015.

 

  1. Nguyen, H.P., H.Q. Doan, P. Rady and K. Tyring. Cellular signaling in sinecatechins-treated external genital and perianal warts: unraveling the mechanism of action of a botanical therapy. Virol Sin 30: 214-217; 2015.

 

  1. Valenzuela, F., K.A. Papp, D. Pariser, K. Tyring, R. Wolk, M. Buonanno, J. Wang, H. Tan and H. Valdez. Effects of tofacitinib on lymphocyte sub-populations, CMV and EBV viral load in patients with plaque psoriasis. BMC Dermatol 15:8; 2015.

 

  1. Kehdy, J., C. Erickson, P. Rady, K. Tyring and A.A. Gaspari. Epidermdysplasia verruciformis: successful treatment with squaric acid dibutylester. Cutis 96: 114-118; 2015.

 

  1. Nguyen, H.P., B.B. Pickrell, J.A. Tschen, Q. He andK. Tyring. Distinct gene expression profiles in two cases of Merkel cell polyomavirus-negative merkel cell carcinoma: shedding light on an esoteric entity. Int J Dermatol e549-e551; 2015.

 

  1. Wu, J.H., H.P. Nguyen, P.L. Rady and K. Tyring. Molecular insight into the viral biology and clinical features of trichodysplasia spinulosa. Br J Dermatol 174:490-498; 2016.

 

  1. Chahoud J, A. Semaan, Y. Chen, M. Cao, A.G. Rieber, P. Rady and K.Tyring. Association between β-genus human papillomavirus and cutaneous squamous cell carcinoma in immunocompetent individuals-a meta-analysis. JAMA Dermatol 152:1354-1364; 2016.

 

  1. Falchook, G.S., P. Rady, J.C. Konopinski, N. Busaidy, K. Hess, S. Hymes, H.P. Nguyen, V.G. Prieto, E. Bustinza-Linares, Q. Lin, K.L. Parkhurst, D.S. Hong, S. Sherman, K. Tyring and Kurzrock R. Merkel cell polyomavirus and human papilloma virus in proliferative skin lesions arising in patients treated with BRAF inhibitors. Arch Dermatol Res. 308:357-365; 2016.

 

  1. Ramanakumar, A.V., P. Naud, C.M. Roteli-Martins, N.S. de Carvalho, C. de Borba, J.C. Teixeira, M. Blatter, A.B. Moscicki, D.M.Harper, B. Romanowski, S.K.Tyring, B. Ramjattan, A. Schuind, G. Dubin, E.L.Franco; HPV-007 Study Group. Incidence and duration of type-specific human papillomavirus infection in high-risk HPV-naïve women: results from the control arm of a phase II HPV-16/18 vaccine trial. BMJ Open. 6:e011371; 2016.

 

  1. Aung, P.P., P.L.Rady, P. Nagarajan, D. Ivan, M.T. Tetzlaff, J.L.Curry, K.Tyring, V.G. Prieto, and C.A. Torres-Cabala. Detection of Merkel Cell Polyoma Virus and Beta Human Papillomavirus in Multiple Eccrine Poromas in a Patient With Acute Leukemia Treated With Stem Cell Transplant. Am J Dermatopathol. Sep 19, 2016.

 

  1. Nemeth, K., A. Gorog, E. Mezey, D. Pinter, E. Kuroli, J. Harsing, L. Kovacs, M. Fischer, P. Rady, P. Sillo, K. Tyring and S. Karpati. Cover Image: Detection of hair follicle-associated Merkel cell polyomavirus in an immunocompromised host with follicular spicules and alopecia. Br J Dermatol. 175:1409; 2016.

 

  1. Wu, J.H., D.N. Cohen, P.L. Rady and K. Tyring. BRAF inhibitor-associated cutaneous squamous cell carcinoma: new mechanistic insight, emerging evidence for a viral involvement, and perspectives on clinical management. Br J Dermatol.  doi: 10.1111/bjd.15348; 2017.

 

  1. Carlson, J.A., P. Rady, P. Kadam, Q. He, R. Simonette and S.K. Tyring. Beta Human Papillomavirus Infection Is Prevalent in Elephantiasis and Exhibits a Productive Phenotype: A Case-Control Study.

Am J Dermatopathol.  doi: 10.1097/DAD.0000000000000681; 2017.

 

  1. Mehta, S.K., M. Nelman-Gonzalez, K. Tyring, Y. Tong, A. Beitman, B.E. Crucian, A.N. Renner and D.L. Pierson. Localization of VZV in saliva of zoster patients. J Med Virol. doi: 10.1002/jmv.24807; 2017.

 

  1. Matsumoto, A., N. Gregory, P.L. Rady, K. Tyring and Carlson, J.A. Brief Report: HPV-17 Infection in Darier Disease With Acrokeratosis Verrucosis of Hopf. Am J Dermatopathol. 39:370-373; 2017.

 

  1. Edwards, L., J.C. Reuttner, T.E. Foster, P.L. Rady and K. Tyring. Perianal Epidermodysplasia Verruciformis Associated With Human Papillomavirus 5 After a Renal Transplant. J Low Genit Tract Dis. 2017 May 12.

 

 

 

 

C.    CLINICAL RESEARCH

 

  1. Reichman, R.C., D. Oakes, W. Bonnez, C. Greisberger, K. Tyring, L. Miller, R.J. Whitley, H. Corvath, M. Weidner, G.G. Krueger, L. Yorkey, N.J. Roberts, Jr., and R. Dolin. Treatment of condyloma acuminatum with three different interferons administered intralesionally: A multicentered, placebo-controlled trial. Ann. Intern. Med. 108:675-679, 1988.

 

  1. Reichman, R.C., D. Oakes, W. Bonnez, D. Brown, H.R. Mattison, A. Bailey- Farchione, M.H. Stoler, L.M. Demeter, K. Tyring, L. Miller, R. Whitley, H. Carveth, M. Weidner, G. Krueger, and A. Choi. Treatment of condyloma acuminatum with three different alpha interferon preparations administered parenterally: A double blind, placebo-controlled trial. J. Infect. Dis. 162 :1270-1276 ; 1990.

 

  1. Kaspar, T.A., R.F. Wagner, S. Jablonska, M. Niimura, and K. Tyring. Prognosis and treatment of advanced squamous cell carcinoma secondary to epidermodysplasia verruciformis: A worldwide multicenter analysis of 11 patients. J. Dermatol. Surg. Oncol. 17:237-240; 1991.

 

  1. Purvis, R.S., and K. Tyring. An outbreak of lindane-resistant scabies treated successfully with 5% Permethrin Cream. J. Am. Acad. Dermatol. 25:1015-1016, 1991.

 

  1. Shepherd, M.E., S.S. Raimer, K. Tyring, and E.B. Smith. Treatment of necrolytic migratory erythema in glucagonoma syndrome. J. Am. Acad. Dermatol. 25:925-928, 1991.

 

  1. Newman, C., R.F. Wagner, K. Tyring, and G.T. Spigel. Squamous cell carcinoma secondary to recessive dystrophic epidermolysis bullosa: A report of 4 patients with 17 primary cutaneous malignancies. J. Dermatol. Surg. Oncol. 18:301-305; 1992.

 

  1. Edwards, L., B. Berman, R.P. Rapini, D.A. Whiting, K. Tyring, H.T. Greenway, S.P. Eyre, D.J. Tanner, E.L. Taylor, E. Peets, and K.A. Smiles. Eradication of cutaneous squamous cell carcinomas by intra-lesional interferon alfa 2b therapy. Arch. Dermatol. 128:1486-1489; 1992.

 

  1. Tyring, S., J. Nahlik, A. Cunningham, J. Marley, M. Heng, and T. Rea. A double blind, randomized, placebo-controlled, parallel group study of oral famciclovir for the treatment of uncomplicated herpes zoster. Intern. Med.123: 89-96; 1995.

 

  1. Gnann, J.W. Jr., C.S. Crumpacker, J.P. Lalezari, J.A. Smith, K. Tyring, K.F. Baum, R.B. Pollard, W.P. Joseph, G.J. Mertz, R.T. Steigbigel, G.A. Cloud, S. Soong, L.C. Sherrill, D.A. DeHertogh, C.A. Laughlin, R.J. Whitley, and the NIAID Collaborative Antiviral Study Group (CASG)/AIDS Clinical Trials Group (ACTG) Herpes Zoster Study Group. Sorivudine versus acyclovir for dermatomal herpes zoster in HIV-infected patients: Results from a randomized, controlled clinical trial. Antimicrob. Agents Chemother. 42:1139-1145; 1998.

 

  1. Tyring, S.K., J. Douglas, L. Corey, S. Spruance, J. Esmann, N. Thin, and the Valaciclovir International Study Group. A randomized, placebo-controlled comparison of oral acyclovir and valacyclovir HCl in patients with recurrent genital herpes infections. Dermatol. 134:185-191; 1998.

 

  1. Söltz-Szöts, J., K. Tyring, P.L. Anderson, R.F. Lucht, M.W. McKendrick, J.L. Diaz Perez, S. Shukla, A.P. Fiddian, and The International Zoster Study Group. A randomized controlled study of acyclovir versus netivudine for treatment of herpes zoster. J. Antimicrobial Chemother. 41:549-556; 1998.

 

  1. Whitley, R.J., H. Weiss, J.W. Gnann, Jr., K. Tyring, G. Mertz, P. Pappas, C.C. Schleupner, F. Hayden, J. Wolfe, S-j. Soong, and the National Institute of Allergy and Infectious Diseases (NIAID) and Collaborative Antiviral Study Group (CASG). Acyclovir with and without prednisone for the treatment of herpes zoster: A randomized, placebo-controlled trial. Ann. Intern. Med. 125: 376-383; 1996.

 

  1. Spruance, S.L., K. Tyring, B. DeGregorio, C. Miller, K. Beutner, and the Valacyclovir Study Group. A large-scale placebo-controlled, dose-ranging trial of peroral valaciclovir for episodic treatment of recurrent herpes genitalis. Arch. Int. Med. 156:1729-1735; 1996.

 

  1. Mertz, G.J., M.O. Loveless, M.J. Levin, S.J. Kraus, S.L. Fowler, D.T. Goade, K. Tyring, and the Collaborative Famciclovir Genital Herpes Research Group. Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women. A multicenter, double blind, placebo-controlled trial. Arch. Int. Med. 157:343-349; 1997.

 

  1. Meadows, K.P., K. Tyring, A.T. Pavia, and T.M. Rallis. Resolution of recalcitrant molluscum contagiosum lesions in HIV-infected patients treated with cidofovir. Arch. Dermatol. 133:987-990; 1997.

 

  1. Tyring, S.K., L. Edwards, D.J. Friedman, W.M. Ransdell, S. Kotner, M.D. Greenberg, J.C. Vance, L. Corey, and C.W. Christensen. Safety and Efficacy of 0.5% podofilox gel in the treatment of external genital and/or perianal warts: A double blind, vehicle-controlled study. Dermatol. 134:33-38; 1998.

 

  1. Zimet, G.D., J. Fortenberry, K.H. Fife, K. Tyring, K. Herne, and J.M. Douglas. Acceptability of genital herpes immunization: The role of health beliefs and health behaviors. Sex. Transm. Dis. 24:555-560; 1997.

 

  1. Swinehart, J.M., R.B. Skinner, J.M. McCarthy, B.H. Miller, K. Tyring, A. Korey, and E.K. Orenberg. Development of intralesional therapy with fluorouracil/adrenaline injectable gel for management of condyloma acuminata: two phase II clinical studies. Genitourin. Med. 73:481-487; 1997.

 

  1. Reitano, M., K. Tyring, W. Lang, C. Thoming, A-M. Worm, S. Borelli, L.O. Chambers, A.T. Gibb, J.M. Robinson, and the International Valaciclovir HSV Study Group. Valaciclovir for the suppression of recurrent genital HSV infection: A large scale dose range-finding study. J. Infect. Dis. 178 :603-610 ; 1998.

 

  1. Beutner, K.R., K. Tyring, K.F. Trofatter, J.M. Douglas, S. Spruance, M.L. Owens, T.L. Fox, A.J. Hougham, and K.A. Schmitt. Imiquimod, a patient applied immune response modifier for the treatment of external genital warts. Antimicro. Agents Chemother. 42:789-794; 1998.

 

  1. Trizna, Z., T. Evans, S. Bruce, K. Hatch, and K. Tyring. A randomized phase II study comparing four different interferon therapies in patients with recalcitrant condylomata acuminata. Sex. Trans. Dis. 25:361-365; 1998.

 

  1. Corey, L., A.G.M. Langenberg, R. Ashley, R.E. Seklovich, A.E. Izu, J. Douglas, H.H. Handsfield, T. Warren, L. Marr, K. Tyring, R. Dicarlo, A. Adimora, P. Leone, C.L. Dekker, R.L. Burke, P. Leong, and S.E. Straus. Recombinant glycoprotein vaccine for the prevention of genital HSV-2 acquisition: two double blind, placebo-controlled trials. JAMA 282:331-340; 1999.

 

  1. Bensen, C., J. Stern, E. Skinner, K. Beutner, M. Conant, K. Tyring, M. Reitano, G. Davis and A. Wald. An interactive, computer-based program to educate patients about genital herpes. J. Sex. Trans. Dis. 26:364-368; 1999.

 

  1. Patel, R., K. Tyring, A. Strand, M.J. Price and D.M. Grant. Impact of suppressive antiviral therapy on the health-related quality of life of patients with recurrent genital herpes infection. Sex. Trans. Inf. 75:398-402; 1999.

 

  1. Tyring, S.K., K.R. Beutner, B.A. Tucker, W.C. Anderson, and R.J. Crooks. Antiviral therapy for herpes zoster.  Fam. Med.  9:863-869; 2000.

 

  1. Tyring, S.K., R. Belanger, W. Bezwoda, P. Ljungman, R. Boon, and R.L. Saltzman. A randomized, double blind trial of famciclovir versus acyclovir for the treatment of localized dermatomal herpes zoster in immunocompromised patients. Cancer Invest. 19:13-22; 2001.

 

  1. Tyring, S.K., R. Engst, C. Corriveau, N. Robillard, S. Trottier, S. Van Slycken, R. Crann, L. Locke, R. Saltzman, and the Collaborative Famciclovir Ophthalmic Zoster Research Group. Famciclovir for ophthalmic zoster: A randomized acyclovir-controlled study. J. Ophthalmol.  85: 576-581; 2001.

 

  1. Wald, A., A.G.M.Langenberg, K. Link, A. Izu, R. Ashley, T. Warren, K. Tyring, J.M.Douglas, Jr., and L. Corey. Effect of condoms on reducing the transmission of herpes simplex virus type-2 from men to women.  JAMA  285:3100-3106; 2001.

 

  1. Spruance, S.L., K. Tyring, M.H. Smith, and T.C. Meng. Application of a topically applied immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes:  a pilot study.  J. Infect. Dis.  184: 196-200; 2001.

 

  1. D., M. Vander Straten, S.K. Tyring.  Treatment of anogenital warts with imiquimod 5% cream followed by surgical excision of residual lesions.  J. Am. Acad. Dermatol. 47(4 Suppl): S212-216; 2002.

 

  1. Stanberry, L.R., S.L. Spruance, L. Cunningham, D. I. Bernstein, A. Mindel, S. Sacks, K. Tyring, F.Y. Aoki, M. Slaoui, M. Denis, P. Vandepapeliere, and G. Dubin. Glycoprotein D adjuvant vaccine to prevent genital herpes.  N. Engl. J. Med.  347: 1652-1661; 2002.

 

  1. Tyring, S.K., Diaz-Mitoma, S.D. Shafran, L.A. Locke, S.L. Sacks and C.L. Young. Oral famciclovir for the suppression of recurrent genital herpes:  The combined data from two randomized controlled trials.  J. Cutan. Med. Surg. 7: 449-454; 2003.

 

  1. Lebwohl, M., K. Tyring, T. Hamilton, D. Toth, S. Glazer, N. Tawfik, P. Walicke, W. Dummer, X. Wang, M Garovay, and D. Pariser. A novel targeted T-cell modulator, efalizumab, for plaque psoriasis. N. Engl. J. Med. 349: 2004-2013; 2003.

 

  1. Corey, L., A. Wald, R. Patel, S.L. Sacks, K. Tyring, T. Warren, J. Douglas, J. Paavonen, R.A. Morrrow, K.R. Beutner, L.S. Stratchounsky, G. Mertz, O.N. Keene, H.A. Watson, D. Tait and M. Vargas-Cortes. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N. Engl. J. Med. 350: 11-20; 2004.

 

  1. Shafran, S.D., K. Tyring, R. Ashton, J. Decroix, C. Forszpaniak, A. Wade, C. Paulet and D. Candaele. Once, twice, or three times daily famciclovir compared with acyclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial. J. Clin. Virol. 29: 248-253; 2004.

 

  1. Bernstein, D.I., F.Y. Aoki, K. Tyring, L.R. Stanberry, C. St-Pierre, S.D. Shafran, G. Leroux-Roels, K. Van Herck, A. Bollaerts and G. Dubin. Safety and Immunogenicity of glycoprotein-D.adjuvant genital herpes vaccine. Clin. Infect. Dis. 40: 1271-1281; 2005.

 

  1. Rana, R.K., J.M. Pimenta, D.M. Rosenberg, K. Tyring, J. Paavonen, S.F. Cook, and N.J. Robinson. Demographic, behavioral and knowledge factors associated with herpes simplex virus type 2 infection among men whose current female partner has genital herpes. Sex Transm Dis 32: 308-313; 2005.

 

  1. Papp, K.A., K. Tyring, M. Lahfa, J. Prinz, C.I. Griffiths, A.M. Nakanishi, R. Zitnik, P.C. van de Kerkhof, L. Melvin and the Etanercept Psoriasis Study Group. A global phase III randomized controlled trial of etanercept in psoriasis: safety, efficacy and effect of dose reduction. Br J Dermatol 152: 1304-1312; 2005.

 

  1. DeBruyn, G., L., M. Vargas-Cortez, T. Warren, K. Tyring, K.H. Fife, J. Lalezari, R.C. Brady, M. Shahmanesh, G. Kinghorn, K.R. Beutner, R. Patel, M.A. Drehobl, P. Horner, T.O. Kurtz, S. McDermott, A. Wald and L. Corey. A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. Vaccine 24: 914-920; 2006.

 

  1. Langley, R.G., W.P. Carey, E.S. Rafal, K. Tyring, I. Caro, X. Wang, G. Wetherill and K.B. Gordon. Incidence of infection during efalizumab therapy for psoriasis: analysis of the clinical trial experience. Clin Ther 27: 1317-1328; 2005.

 

  1. Tyring, S.K., A. Gottlieb, K. Papp, K. Gordon, C. Leonardi, A. Wang, D. Lalla, M. Woolley, A. Jahreis, R. Zitnik, D. Cella and R. Krishnan. Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomized phase III trial. Lancet 367: 29-35; 2006.

 

  1. Aoki, F.Y., K. Tyring, F. Diaz-Mitoma, G. Gross, J. Gao and K. Hamed. Single-day, patient-initiated famciclovir therapy for recurrent genital herpes: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis 42: 8-13; 2006.

 

  1. Wu, J.J., C.C. Ramirez, C.A. Alonso, N. Mendoza, B. Berman and K. Tyring. Dermatology residency program characteristics that correlate with graduates selecting an academic dermatology career. Arch Dermatol. 142: 845-850; 2006.

 

  1. Oliveira, W.R., P.L. Rady, C. Festa, E.A. Rivitti and K. Tyring. Skin cancer in epidermodysplasia verruciformis patients from Brazil. JEADV 20: 1154-1156; 2006.

 

  1. Matalon, R. K. Michals-Matalon, G. Bhatia, E. Grechanina, P. Novikov, J.D. McDonald, J. Grady, K. Tyring and F. Guttler. Large neutral amino acids in the treatment of phenylketonuria (PKU). J. Inherit. Metab. Dis. 29: 732-738; 2006.

 

  1. Spruance, S., F.Y. Aoki, Tyring, L. Stanberry, R. Whitley, K. Hamed. Short-course therapy for recurrent genital herpes and herpes labialis. J Fam Pract. 56: 30-36; 2007.

 

  1. Tyring, S.K., F. Diaz-Mitoma, L.G. Padget, M. Nunez, G. Poland, W.M. Cassidy, N.D. Bundick, J. Li, I.S. Chan, J.E. Stek, P.W. Annunziato, Protocol 009 Study Group. Safety and tolerability of a high-potency zoster vaccine in adults >/= 50 or years of age. 26: 1877-1883; 2007.

 

  1. Matalon, R., K. Michals-Matalon, G. Bhatia, A.B. Burlina, C. Braga, L. Fiori, M. Giovannini, E. Grechanina, P. Novikov, J. Grady, K. Tyring, F. Guttler. Double blind placebo control trial of large neutral amino acids in treatment of PKU: effect on blood phenylalanine. J Inherit Metab Dis. 30: 153-158; 2007.

 

  1. Madkan, V.K., A. Arora, M. Babb-Tarbox, S. Aboutlabeti, Tyring. Open-label study of valacyclovir 1.5 g twice daily for the treatment of uncomplicated herpes zoster in immunocompetent patients 18 years of age or older. J Cutan Med Surg. 11: 89-98; 2007.

 

  1. Herrera, S., L.A. Correa, J.C. Wolff, A. Gaviria, K. Tyring, G. Sanclemente. Effect of imiquimod in anogenital warts from HIV-positive men. J Clin Virol. 39: 210-214; 2007.

 

  1. Tyring, S., K.B. Gordon, Y. Poulin, R.G. Langley, A.B. Gottliev, M. Dunn, A. Jahreis. Long-term safety and efficacy of 50 mg of etanercept twice weekly in patients with psoriasis. Arch Dermatol. 143: 719-726; 2007.

 

  1. Ahmed, B., J.A. Tschen, P.R. Cohen, M.H. Zaki, P.L. Rady, K. Tyring, R.E. Corringham, R. Kurzrock. Cutaneous castleman’s disease responds to anti interleukin-6 treatment. Mol Cancer Ther. 6:2386-2890; 2007.

 

  1. Menter, A., K. Tyring, K. Gordon, A.B. Kimball, C.L. Leonardi, R.G. Langley, B.E. Strober, M. Kaul, Y. Gu, M. Okun, K. Papp. Adalimumab therapy for moderate to severe psoriasis: A randomized, controlled phase III trial. J Am Acad Dermatol. 58: 106-115; 2008.

 

  1. Wu, J.J., K.F. Davis, C.C. Ramirez, C.A. Alonso, B. Berman, K. Tyring. MD/PhDs are more likely than MDs to choose a career in academic dermatology. Dermatol Online J. 14: 27; 2008.

 

  1. Wu, J.J., C.C. Ramirez, C.A. Alonso, B. Berman, K. Tyring. Ranking the dermatology programs based on measurements of academic achievement. Dermatol Online J. 13: 3; 2007.

 

  1. Gollnick, H., R. Kaufmann, D. Stough, H. Heikkila, K. Andriano, A. Grinienko, P. Jimenez, Pimecrolimus Cream 1% in (adult) Eczema: Prevention of Progression Multicentre Investigator Study Group (i.e. K. Tyring). Pimecrolimus cream 1% in the long-term management of adult atopic dermatitis: prevention of flare progression. A randomized controlled trial. Br J Dermatol. 158: 1083-1093; 2008.

 

  1. Bavaro, J.B., L. Drolette, D.M. Koelle, J. Almekinder, T. Warren, Tyring, A. Wald. One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection. Sex Transm Dis. 35: 383-386; 2008.

 

  1. Arora, A., N. Mendoza, J. Brantley, B. Yates, L. Dix, Tyring. Double-blind study comparing 2 dosages of valacyclovir hydrochloride for the treatment of uncomplicated herpes zoster in immunocompromised patients 18 years of age and older. J Infect Dis. 197- 1289-1295; 2008.

 

  1. Hicks, L.D., R.H. Cook-Norris, N. Mendoza, V. Madkan, A. Arora, K. Tyring. Family history as a risk factor for herpes zoster: a case-control study. Arch Dermatol. 144: 603-608; 2008.

 

  1. Abudalu, M., Tyring, W. Koltun, N. Bodsworth, K. Hamed. Single-day, patient-initiated famciclovir therapy versus 3-day valacyclovir regimen for recurrent genital herpes: a randomized, double-blind, comparative trial. Clin Infect Dis. 47: 651-658; 2008.

 

  1. Buchbinder, S.P., D.V. Mehrotra, A. Duerr, D. W. Fitzgerald, R. Mogg, D. Li, P.B. Gilbert, J. R. Lama, M. Marmor, C. Del Rio, M.J. McElrath, D.R. Casimiro, K.M. Gottesdiener, J.A. Chodakewitz, L. Corey, M.N. Robertson, Step Study Protocol Team (i.e. K. Tyring). Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomized, placebo-controlled, test-of-concept trial. Lancet. 372: 1881-1893; 2008.

 

  1. McElrath, M.J., S.C. De Rosa, Z. Moodie, S. Dubey, L. Kierstead, H. Janes, O.D. Defawe, D.K. Carter, J. Hural, R. Akondy, S.P. Buchbinder, M.N. Robertson, D.V. Mehrotra, S.G. Self, L. Corey, J.W. Shiver, D.R. Casimiro, Step Study Protocol Team (i.e. K. Tyring). HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet. 372: 1894-1905; 2008.

 

  1. Bodsworth, N., K. Fife, W. Koltun, Tyring, M. Abudalu, M. Prichard, K. Hamed. Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance. Curr Med Res Opin. 25: 483-487; 2009.

 

  1. Dworkin, R.H., R.L. Barbano, K. Tyring, R.F. Betts, M.P. McDermott, J. Pennella-Vaughan, G.J. Bennett, E. Berber, J.W. Gnann, C. Irvine, C. Kamp, K. Kieburtz, M.B. Max, K.E. Schmader. A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster. Pain. 142: 209-217; 2009.

 

  1. GlaxoSmithKline Vaccine HPV-007 Study Group, B. Romanowski, P.C. de Borba, P.S. Naud, C.M. Roteli-Martins, N.S. De Carvalho, J.C. Teixeira, F. Aoki, B. Ramjattan, R.M. Shier, R. Somani, S. Barbier, M.M. Blatter, C. Chambers, D. Ferris, S.A. Gall, F.A. Guerra, D.M. Harper, J.A. Hedrick, D.C. Henry, A.P. Korn, R. Kroll, A.B. Moscicki, W.D. Rosenfedl, B.J. Sullivan, C.S. Thoming, K. Tyring, C.M. Wheeler, G. Dubin, A. Schuind, T. Zahaf, M. Greenacre and A. Sgriobhadair. Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 years. Lancet. 2009 374:1975-1985; 2009.

 

  1. Mills, R. K. Tyring, M.J. Levin, J. Parrino, X. Li, K.E. Coll, J.E. Stek, K. Schlienge, I.S. Chan and J.L. Silber. Safety, tolerability, and immunogenicity of zoster vaccine in subjects with a history of herpes zoster. Vaccine. 28:4204-4209; 2010.

 

  1. Tyring, S.K., N. Mendoza, M. Appell, A. Bibby, R. Foster, T. Hamilton and M. Lee. A calcipotriene/betamethasone dipropionate two-compound scalp formulation in the treatment of scalp psoriasis in Hispanic/Latino and Black/African American patients: results of the randomized, 8-week, double-blind phase of a clinical trial. Int J Dermatol. 49:1328-1333; 2010.

 

  1. Hull, C.M., J. Harmenberg, E. Arlander, F. Aoki, J. Bring, B. Darpo, M.J. Levin, K. Tyring, S.L. Spruance and the ME-609 Study Group. Early treatment of cold sores with topical ME-609 decreases the frequency of ulcerative lesions: a randomized, double-blind, placebo-controlled, patient-initiated clinical trial. J Am Acad Dermatol. 64:696.e1-11; 2011.

 

  1. Leonardi, C., R.G. Langley, K. Papp, K. Tyring., N. Wasel, R. Vender, K. Unnebrink, S.R. Gupta, W.C. Valdecantos and J. Bagel. Adalimumab for treatment of moderate to severe chronic plaque psoriasis of the hands and feet: efficacy and safety results from REACH, a randomized, placebo-controlled, double-blind trial. Arch Dermatol. 147:429-436; 2011.

 

  1. LaPolla, W., C. DiGiorgio, K. Haitz, G. Magel, N. Mendoza, J. Grady, W. Lu and K. Tyring. Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study. Arch Dermatol. 147:901-907; 2011.

 

  1. Leonardi, C., K. Papp, B. Strober, K. Reich, A. Asahina, Y. Gu, J. Beason, S. Rozzo and K. Tyring. The long-term safety of adalimumab treatment in moderate to severe psoriasis: a comprehensive analysis of all adalimumab exposure in all clinical trials. Am J Clin Dermatol. 12:321-337; 2011.

 

  1. Baker, D.A., D.G. Ferris, M.G. Martens, K.H. Fife, K. Tyring, L. Edwards, A. Nelson, K. Ault, K.F. Trofatter, T. Liu, S. Levy and J. Wu. Imiquimod 3.75% cream applied daily to treat anogenital warts: combined results from women in two randomized, placebo-controlled studies. Infect Dis Obstet Gynecol. 2011:806105; 2011.

 

  1. Javed, S., Q.U. Kamili, N. Mendoza and K. Tyring. Possible association of lower rate of postherpetic neuralgia in patients on anti-tumor necrosis factor-α. J Med Virol. 83:2051-2055; 2011.

 

  1. Hernandez, P.O., S. Javed, N. Mendoza, W. LaPolla, L.D. Hicks and K. Tyring. Family history and herpes zoster risk in the era of shingles vaccination. J Clin Virol. 52:344-348; 2011.

 

  1. Bagel, J., C. Lynde, K. Tyring, G. Kricorian, Y. Shi and P. Klekotka. Moderate to severe plaque psoriasis with scalp involvement: A randomized, double-blind, placebo-controlled study of etanercept. J Am Acad Dermatol. 67: 86-92; 2012.

 

  1. Pariser, D.M., C.L. Leonardi, K. Gordon, A.B. Gottlieb, K. Tyring, K.A. Papp, J. Li and S.W. Baumgartner. Integrated safety analysis: Short- and long-term safety profiles of etanercept in patients with psoriasis. J Am Acad Dermatol. 67: 245-256; 2012.

 

  1. Brodell, R.T., B.J. Schlosser, E. Rafal, D. Toth, K. Tyring, A. Wertheimer, N. Kerrouche and D. Bucher. A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne. J Dermatol Treat. 23:26-34; 2012.

 

  1. Vermeulen, J.N., J.M. Lange, K. Tyring, P.H. Peters, M. Nunez, G. Poland, M.J. Levin, C. Freeman, I. Chalikonda, J. Li, J.G. Smith, M.J. Caulfield, J.E. Stek, I.S. Chan, R. Vessey, F.P. Schodel, P.W. Annunziato, K. Schlienger and J.L. Silber. Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults ≥60 years of age. Vaccine. 30:904-910; 2012.

 

 

  1. K. Tyring, S. Plunkett, A.R. Scribner, R.E. Broker, J.N. Herrod, L.T. Handke, J.M. Wise and P.A. Martin. Valomaciclovir versus valacyclovir for the treatment of acute herpes zoster in immunocompetent adults: A randomized, double-blind, active-controlled trial. J Med Virol 84: 1224-1232; 2012.

 

  1. Tyring, S.K., A. Wald, N. Zadeikis, S. Dhadda, K. Takenouchi and R. Rorig.

ASP2151 for the Treatment of Genital Herpes: A Randomized, Double-Blind, Placebo- and Valacyclovir-Controlled, Dose-Finding Study. J Infect Dis. 205: 1100-1110; 2012.

 

  1. Duerr, A., Y. Huang, S. Buchbinder, R.W. Coombs, J. Sanchez, C. del Rio, M. Casapia, S. Santiago, P. Gilbert, L. Corey, M.N. Robertson and Step/HVTN 504 Study Team (i.e. K. Tyring). Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study). J Infect Dis 206: 258-266; 2012.

 

  1. Javed, S., F. Javed, R.M. Mays and K. Tyring. Herpes zoster vaccine awareness among people > 50 years of age and its implications on immunization. Dermatol Online J 18:2; 2012.

 

 

  1. Tyring, S.K., Bagel, C. Lynde, P. Klekotka, E.H. Thompson, S.R. Gandra, Y. Shi and G. Kricorian. Patient-reported outcomes in moderate-to-severe plaque psoriasis with scalp involvement: results from a randomized, double-blind, placebo-controlled study of etanercept. J Eur Acad Dermatol Venereol. 27: 125-128; 2013.

 

  1. Lebwohl, M., S. Shumack, L. SteinGold, A. Melgaard, T. Larsson and K. Tyring. Long-term follow-up study of ingenol mebutate gel for the treatment of actinic keratosis. JAMA Dermatol 149; 666-670; 2013.

 

  1. Javed, S., S.A. Javed, R.M. Mays and K. Tyring. Clinical characteristics and awareness of skin cancer in Hispanic patients. Dermatol Online J 19: 19623; 2013.

 

  1. Hull, C.M., M.J. Levin, K. Tyring and S.L. Spruance. Novel composite efficacy measure to demonstrate the rationale and efficacy of combination antiviral-anti-inflammatory treatment for recurrent herpes simplex labialis. Antimicrob Agents Chemother 58: 1273-1278; 2014.

 

  1. Wald, A., L. Corey, B. Timmler, A. Magaret, T. Warren, K. Tyring, C. Johnston, J. Kriesel, K. Fife, L. Galitz, S. Stoelben, M.L. Huang, S. Selke, H.P. Stobernack, H. Ruebsamen-Schaeff and A. Birkmann. Helicase-primase inhibitor pritelivir for HSV-2 infection. N Engl J Med 370: 201-210; 2014.

 

  1. Berman, B., G. Goldenberg, C.W. Hanke, K. Tyring, W.P. Werschler, K. M. Knudsen, J. Goncalves, T. Larsson, T. Skov and N. Swanson. Efficacy and safety of ingenol mebutate 0.015% gel 3 weeks after cryosurgery of actinic keratosis: 11 week results. J Drugs Dermatol 13: 154-160; 2014.

 

  1. Menter, A., K.A. Papp, H. Tan, K. Tyring, R. Wolk and M. Buonanno. Efficacy of tofacitinib, an oral janus kinase inhibitor, on clinical signs of moderate-to-severe plaque psoriasis in different body regions. J Drugs Dermatol 13: 252-256; 2014.

 

  1. Berman, B., G. Goldenberg, C.W. Hanke, K. Tyring, W.P. Werschler, K.M. Knudsen, T. Larsson and N. Swanson. Efficacy and safety of ingenol mebutate 0.015% gel after cryosurgery of actinic keratosis: 12-month results. J Drugs Dermatol 13: 741-747; 2014.

 

  1. Bieber, T., O. Chosidow, N. Bodsworth, K. Tyring, J. Hercogova, M. Bloch, M. Davis, M. Lewis, D. Boutolleau, P. Attali and LIP Study Group. Efficacy and safety of aciclovir mucoadhesive buccal tablet in immunocompetent patients with labial herpes (LIP Trial): a double-blind, placebo-controlled, self-initiated trial. J Drugs Dermatol 13: 791-798; 2014.

 

  1. Langley, R.G., B.E. Elewski, M. Lebwohl, K. Reich, C.E. Griffiths, K. Papp, L. Puig, H. Nakagawa, L. Spelman, B. Sigurgeirsson, E. Rivas, T.F. Tsai, N. Wasel, K. Tyring, T. Salko, I. Hampele, M. Notter, A. Karpov, S. Helou, C. Papavassilis, ERASURE Study Group and FIXTURE Study Group. Secukinumab in plaque psoriasis-results of two phase 3 trials. N Engl J Med 371: 326-338; 2014.

 

  1. Bagel, J., E. Levi, K. Tyring and M.L. Knuckles. Real-life treatment profile of calcipotriene and betamethasone dipropionate topical suspension in patients with psoriasis vulgaris. J Drugs Dermatol 13: 1374-1379; 2014.

 

  1. SteinGold, L., L. Kircik, J. Fowler, J.M. Jackson, J. Tan, Z. Draelos, A. Fleischer, M. Appell, M. Steinhoff, C. Lynde, J. Sugarman, H. Liu, J. Jacovella and Ivermectin Phase 3 Study Group (i.e. K. Tyring). Long-term safety of ivermectin 1% cream vs azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials. J Drugs Dermatol 13: 1380-1386; 2014.

 

  1. Blauvelt, A., J.C. Prinz, A.B. Gottlieb, K. Kingo, H. Sofen, M. Ruer-Mulard, V. Singh, R. Pathan, C. Papavassilis, S. Cooper and FEATURE Study Group (i.e. K. Tyring). Secukinumab administration by pre-filled syringe: efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE). Br J Dermatol 172: 484-493; 2015.

 

  1. Apter, D., C.M. Wheeler, J. Paavonen, X. Castellsague, S.M. Garland, S.R. Skinner, P. Naud, J. Salmeron, S.N. Chow, H.C. Kitchener, J.C. Teixeira, U. Jaisamrarn, G. Limson, A. Szarewski, B. Romanowki, F.Y. Aoki, T.F. Schwarz, W.A. Poppe, F.X. Bosch, A. Mindel, P. deSutter, K. Hardt, T. Zahaf, D. Descamps, F. Struyf, M. Lehtinen, G. Dubin and HPV PATRICIA Study Group (i.e. K. Tyring). Efficacy of human papillomavirus 16 and 18 (HPV 16/18) AS04-adjuvanted vaccine against cervical infection and precancer in young women: final event-driven analysis of the randomized, double-blind PATRICIA trial. Clin Vaccine Immunol 22: 361-373; 2015.

 

  1. De Oliveira, W.R., S.L.L. da Cruz, C.F. Neto and K. Tyring. Deleterious effect of radiation therapy on epidermodysplasia verruciformis patients. J Cutan Med Surg 19: 416-421; 2015.

 

  1. Koo, J., K. Tyring, W.P. Werschler, S. Bruce, M. Olesen, J. Villumsen and J. Bagel. Superior efficacy of calcipotriene and betamethasone dipropionate aerosol foam versus ointment in patients with psoriasis vulgaris-A randomized phase II study. J Dermatolog Treat 7: 1-8; 2015.

 

  1. Champagne, C., L. Moore, R. Reule, J.A. Dyer, P. Rady, K. Tyring and J.P. North. Cornoid lamella-like structures in HIV-associated epidermodysplasia verruciformis: a unique histopathologic finding. Am J Dermatopathol 37: 929-932; 2015.

 

 

  1. Lebwohl, M., B. Strober, A. Menter, K. Gordon, J. Weglowska, L. Puig, K. Papp, L. Spelman, D. Toth, F. Kerdel, A.W. Armstrog, G. Stingl, A.B. Kimball, H. Bachelez, J. Wu, J. Crowley, R.G. Langley, T. Blicharski, C. Paul, J. Lacour, K. Tyring, L. Kircik, S. Chimenti, K.C. Duffin J. Bagel, J. Koo, G. Aras, J. Li, W. Song, C.E. Milmont, Y. Shi, N. Erondu, P. Klekotka, B. Kotzin and A. Nirula. AMAGINE-2 and AMAGINE-3: Phase 3 studies to evaluate the efficacy and safety of induction and maintenance regimens of brodalumab compared with placebo and ustekinumab in patients with moderate to severe plaque psoriasis. N Engl J Med 373: 1318-1328; 2015.

 

  1. Papp, K.A., J.G. Krueger, S.R. Feldman, R.G. Langley, D. Thaci, H. Torii, K. Tyring, R. Wolk, A. Gardner, C. Mebus, H. Tan, Y. Luo, P. Gupta, L. Mallbris and S. Tatulych. Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: Long-term efficacy and safety results from 2 randomized phase-III studies and 1 open-label long-term extension study. J Am Acad Dermatology 74:841-850; 2016.

 

  1. Lebwohl, M., K.Tyring, M. Bukhalo, J. Alonso-Llamazares, M. Olesen, D. Lowson and P. Yamauchi. Fixed Combination Aerosol Foam Calcipotriene 0.005% (Cal) Plus Betamethasone Dipropionate 0.064% (BD) is More Efficacious than Cal or BD Aerosol Foam Alone for Psoriasis Vulgaris: A Randomized, Double-blind, Multicenter, Three-arm, Phase 2 Study. J Clin Aesthet Dermatol. 9:34-41; 2016.

 

  1. Tong, Y., Y.K.Song and S.K. Tyring. Resolution of Porphyria Cutanea Tarda in Patients With Hepatitis C Following Ledipasvir-Sofosbuvir Combination Therapy. JAMA Dermatol. 152:1393-1395; 2016.

 

  1. Solomon, J.A., K.Tyring, G. Staedtler, M. Sand, R. Nkulikiyinka and K. Shakery. Investigator-reported efficacy of azelaic acid foam 15% in patients with papulopustular rosacea: secondary efficacy outcomes from a randomized, controlled, double-blind, phase 3 trial. Cutis. 98:187-194; 2016.

 

  1. Korman, N.J., H. Sofen, S. Fretzin, P. Rich, Y. Zhao, V. Herrera, J. Nyirady, N. Williams, M. Mordin and K. Tyring. Secukinumab provides better relief from the impact of psoriasis on daily activities and personal relationships than etanercept: results of two phase 3 placebo-controlled randomized clinical trials in moderate-to-severe psoriasis. J Dermatolog Treat. 21:1-6; 2016.

 

  1. Tyring, S.K., J.A. Solomon, G. Staedtler, J.P.Lott, R. Nkulikiyinka and Shakery. Patient-reported outcomes of azelaic acid foam 15% for patients with papulopustular rosacea: secondary efficacy results from a randomized, controlled, double-blind, phase 3 trial. Cutis. 98:269-275; 2016.

 

  1. Thiboutot, D.M., L. Kircik, A. McMichael, F.E. Cook-Bolden, K. Tyring, D.R. Berk, J.E. Chang-Lin, V. Lin and A. Kaoukhov. Efficacy, Safety, and Dermal Tolerability of Dapsone Gel, 7.5% in Patients with Moderate Acne Vulgaris: A Pooled Analysis of Two Phase 3 Trials. J Clin Aesthet Dermatol. ;9:18-27; 2016.

 

  1. Tyring, S.K., P. Lee, G.T. HillJr, J. C. Silverfield, A. Y. Moore, T. Matkovits and J. Sullivan-Bolyai. FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial. J Med Virol. Dec 12. doi: 10.1002/jmv.24750; 2016.

 

  1. Wald, A., B. Timmler, A. Magaret, T. Warren, K. Tyring, C. Johnston, K. Fife, S. Selke, M.L. Huang, H.P. Stobernack, H. Zimmermann, L. Corey, A. Birkmann and H. Ruebsamen-Schaeff. Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial. JAMA. 316:2495-2503; 2016. doi: 10.1001/jama.2016.18189. Erratum in: JAMA. 317:648; 2017.

 

  1. Bagel, J., K. Tyring, K.C.Rice, D.H.Collier, G. Kricorian, J. Chung, J. Iles, B.S. Stolshek, A. Kaliyaperumal and K.A. Papp. Open-label study of etanercept treatment in patients with moderate to severe plaque psoriasis who lost a satisfactory response to adalimumab. Br J Dermatol. doi: 10.1111/bjd.15381; 2017.

 

 

  1. Blauvelt, A., K. Reich, T.F. Tsai, K. Tyring, F. Vanaclocha, K. Kingo, M. Ziv, A. Pinter, R. Vender, S. Hugot, R. You, M. Milutinovic and D. Thaçi. Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate-to-severe plaque psoriasis up to 1 year: Results from the CLEAR study. J Am Acad Dermatol. 76:60-69; 2017.

 

  1. Bernstein, D.I., A. Wald, T. Warren, K. Fife, K.Tyring, P. Lee, N. Van Wagoner, A. Magaret, J.B. Flechtner, S. Tasker, J. Chan, A. Morris and S. Hetherington. Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings from a Randomized Trial. J Infect Dis. doi: 10.1093/infdis/jix004; 2017.

 

  1. Blauvelt, A., K. Reich, R.B. Warren, J.C. Szepietowski, B. Sigurgeirsson, K. Tyring, I. Messina, V. Bhosekar, J. Oliver, C. Papavassilis, J. Frueh and R.G.B. Langley. Secukinumab re-initiation achieves regain of high response levels in patients who interrupt treatment for moderate to severe plaque psoriasis. Br J Dermatol. 2017 May 12. doi: 10.1111/bjd.15656

 

  1. Papp, K.A., A. Blauvelt, M. Bukhalo, M. Gooderham, J. Krueger, J.P. Lacour, A. Menter, S. Philipp, H. Sofen, K. Tyring, B.R. Berner, S. Visvanathan, C. Pamulapati, N. Bennett, M. Flack, P. Scholl and S.J. Padula. Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis.

N Engl J Med. 376:1551-1560; 2017.

 

 

 

 

 

 

 

 

  1. REVIEWS

 

  1. Tyring, S.K. Antitumor actions of interferons: direct, indirect, and synergy with other treatment modalities. In J. Dermatol. 26:549-556, 1987.

 

  1. Tyring, S.K. Treatment of condyloma acuminatum with interferon. Seminars Oncol. 15:35‑40, 1988.

 

  1. Baron, S., K. Tyring, W.R. Fleischmann, Jr., D.H. Coppenhaver, D.W. Niesel, G.R. Klimpel, G.J. Stanton, and T.K. Hughes. The interferons: Mechanisms of action and clinical applications. JAMA 266:1375-1383, 1991.

 

  1. Purvis, R.S., E.L. Beightler, D.G. Diven, R.L. Sanchez, and K. Tyring. Strongyloides stercoralis hyperinfection. Int. J. Dermatol. 31:160-164, 1992.

 

  1. Tyring, S.K. Natural history of varicella virus.  Seminars Dermatol. 11:211-217; 1992.

 

  1. Lewis, G.L., K. Tyring, and R.F. Wagner. Nonsurgical therapy of thin melanoma. Cutis 50:377-379; 1992.

 

  1. Tyring, S.K. Reactive erythemas: Erythema annulare centrifugum and erythema gyratum repens. Clinics Dermatol. 11:135-139; 1993.

 

  1. Tyring, S.K. The role of human papillomaviruses in skin cancer. Cancer Bulletin 45:212-219; 1993.

 

  1. Rockley, P.F., R.F. Wagner, P. Rady, and K. Tyring. The role of oncogenes and anti-oncogenes in skin cancer. Skin Cancer 8:7-17; 1993.

 

  1. Schlesinger, I.H., R.F. Wagner, and K. Tyring. Potential and limitations of topical sunscreens. Skin Cancer 8:19-32; 1993.

 

  1. Schlesinger, I.H., M. Oelrich, and K. Tyring. The range of clinical presentations of Norwegian scabies in AIDS patients. South. Med. J. 87:352-356; 1994.

 

  1. Rockley, P.F., N.Trieff, R.F. Wagner, Jr., and K. Tyring. Nonsunlight risk factors for malignant melanoma. Part I: Chemical agents, physical conditions and occupation. Int. J. Dermatol. 33:398-406; 1994.

 

  1. Rockley, P.F., N. Trieff, R.F. Wagner, and K. Tyring. Nonsunlight risk factors for malignant melanoma. Part II: Immunity, genetics and work place prevention. Int. J. Dermatol. 33:462-467; 1994.

 

  1. Tyring, S.K., A.E. Friedman-Kien, H.L.Kent, J.L. Currie, and R.T. Brodell. Alpha interferon in the management of genital warts. Female Patient 18:33-39; 1993.

 

  1. Rockley, P.F., and K. Tyring. Pathophysiology and clinical manifestations of herpes zoster virus infection. Int. J. Dermatol. 33:227-232; 1994.

 

  1. Cirelli, R.A., and K. Tyring. Interferons in human papillomavirus infections. Antiviral Res. 24:191-204; 1994.

 

  1. Herne, K., R. Cirelli, P.F. Rockley, and K. Tyring. From chickenpox to shingles: Clinical manifestations and pathophysiology of VZV infections. J. Geriatr. Derm. 2:3A-10A; 1994.

 

  1. Rockley, P.F., and K. Tyring. Interferons alpha, beta and gamma therapy of ano-genital human papillomavirus infections. Pharmac. Therap. 65:265-287; 1995.

 

  1. Cirelli, R.A., and K. Tyring. Major therapeutic uses of interferons. Clin. Immunotherap. 3:27-87; 1995.

 

  1. Memar, O., and K. Tyring. Cutaneous viral infections. J. Am. Acad. Dermatol. 33:279-287; 1995.

 

  1. Memar, O., and K. Tyring. Antiviral agents in dermatology: current status and future prospects. Int. J. Dermatol. 34:597-606; 1995.

 

  1. Memar, O., R. Cirelli, P.C. Lee, and K. Tyring. Cutaneous manifestations of human immunodeficiency virus infection. J. Am. Podiatric Assoc. 85:362-374; 1995.

 

  1. Cirelli, R.A., P.C. Lee, and K. Tyring. Therapy and prophylaxis of viral diseases with cutaneous manifestations. Can. J. Dermatol. 7:795-804; 1995.

 

  1. Tyring, S.K. Interferons: Biochemistry and mechanisms of action. J. Obstet. Gynecol. 172:1350-1353; 1995.

 

  1. Memar, O.M., I. Arany, and K. Tyring. Skin associated lymphoid tissue in human immunodeficiency virus 1, human papillomavirus, and herpes simplex virus infections. J. Invest. Dermatol. 105:99-104; 1995.

 

  1. Herne, K., R. Cirelli, P. Lee, and K. Tyring. Current experience with famciclovir for the treatment of herpesvirus infections. Today’s Therapeutic Trends 13:29-37; 1995.

 

  1. Memar, O.M, P.L. Rady, and K. Tyring. Human herpesvirus-8: Detection of novel herpesvirus-like DNA sequences in Kaposi’s sarcoma and other lesions. J. Mol. Med. 73:603-609; 1995.

 

  1. McCrary, M.L., O.M. Memar, and K. Tyring. The role of HHV-8 in malignancy. Fitzpatrick J. Clin. Dermatol. 3:27-28; 1995.

 

  1. McCrary, J.L., O.M. Memar, K.B. Herne, and K. Tyring. Drugs with antiviral activity used in clinical dermatology. Fitzpatrick J. Clin. Dermatol. 3:44-51; 1995.

 

  1. Cirelli, R., K. Herne, and K. Tyring. Interferons: an overview of their pharmacology. Clin. Immunotherap. 5:22-30; 1996.

 

  1. K. Tyring. Efficacy of famciclovir in the treatment of herpes zoster. Seminars Dermatol. 15:527-531; 1996.

 

  1. Au, W.W., G.S. Wilkenson, K. Tyring, M.S. Legator, R. El Zein, L. Hallberg, and M.Y. Heo. Monitoring populations for DNA repair deficiency and for cancer susceptibility. Environmental Health Perspectives 104(sup.3): 579-584; 1996.

 

  1. Lavoie, S.R., S.E. Starr, and K. Tyring. New Antiviral agents: are they really better? Patient Care 30:61-71; 1996.

 

  1. Tyring, S.K. Herpes zoster: Effective therapy means early treatment. Hospital Pract. 31:137-144; 1996.

 

  1. Cirelli, R., K. Herne, M. McCrary, P. Lee, and K. Tyring. Famciclovir; review of clinical efficacy and safety. Antiviral Res. 29:141-151; 1996.

 

  1. Herne, K., R. Cirelli, P. Lee, and K. Tyring. Antiviral therapy of acute herpes zoster in older patients. Drugs and Aging 8:97-112; 1996.

 

  1. Huse, D.M., S. Schainbaum, A.J. Kirsch, and K. Tyring. Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia. Am. J. Health-Syst. Pharm. 54:1180-84; 1997.

 

  1. Wagner, R.F., H. Brysk, and K. Tyring. Revisiting the Michel/Green controversy of 1879: Was Carron du Villards the first to use probe/needle electrolysis for permanent hair destruction? Int J. Dermatol. 36:947-951; 1997.

 

  1. Chopra, K.F., and Tyring, S.K. The impact of the human immunodeficiency virus on the human papillomavirus epidemic. Dermatol. 133:629-633; 1997.

 

  1. Tyring, S.K. Introduction: Perspectives on human papillomavirus infection. J. Med. 102(5A):1-2; 1997.

 

  1. Beutner, K.R. and K. Tyring. Human papillomavirus and human disease. Am. J. Med. 102(5A): 9-15; 1997.

 

  1. Evans, T., and K. Tyring. Treatment of viral diseases with retinoids. Dermatol. Therapy 7:31-36; 1998.

 

  1. Tyring, S.K. Immune response modification : imiquimod. Australasian J. Dermatol. 39:511-513; 1998.

 

  1. Tyring, S.K. Advances in the treatment of herpesvirus infection: The role of famciclovir. Therap. 20:661-670; 1998.

 

  1. Trizna, Z., and K. Tyring. Antiviral treatment of diseases in pediatric dermatology. Dermatol. Clinics 16:539-552; 1998.

 

  1. Evans, T., and K. Tyring. Review of antivirals in dermatology. Dermatol. Clinics 16:409-420; 1998.

 

  1. Carlton, S., T. Evans, and K. Tyring. New antiviral agents for dermatologic disease. Seminars in Cutaneous Medicine and Surgery 17:243-255; 1998.

 

  1. Carlton, S.D., T.Y. Evans, and K. Tyring. Herpes : atypical clinical manifestations. Dermatol. Clinics 16:783-788; 1998.

 

  1. Czelusta, A.J., T.Y. Evans, I. Arany, and K. Tyring. A guide to immunotherapy of genital warts. Bio. Drugs 11:319-332; 1999.

 

  1. Langley, P., K. Tyring, and M. Smith. The cost effectiveness of patient applied vs. provider administered intervention strategies for the treatment of external genital warts. Am. J. Managed Care 5:69-77; 1999.

 

  1. Severson, J.L., and K. Tyring. Viral disease update. Current Problems in Dermatology 11:37-72; 1999.

 

  1. Beutner, K., D.J. Wiley, J.M. Douglas, K. Tyring, K. Fife, K. Trofatter and K.M. Stone. Genital warts and their treatment. Clin. Inf. Dis. 28(supp. 1): S37-S56; 1999.

 

  1. McCrary, M.L., J. Severson, and K. Tyring. Varicella zoster virus. J. Am. Acad. Dermatol. 41:1-14; 1999.

 

  1. Vander Straten, M., D. Carrasco, M.S. Patterson, M.L. McCrary, D. J. Meyer, and K. Tyring. Tobacco use and skin diseases. South. Med. J. 94: 621-634; 2001.

 

  1. Czelusta, A.J., T.Y. Evans, and K. Tyring. Periodic synopsis: Sexually transmitted diseases. J. Am. Acad. Dermatol. 41:614-623; 1999.

 

  1. Matalon, R., P.L. Rady, and K. Tyring. Progress in Canavan disease: Creation of knock out mouse. J. Mol. Neurosci. 13:225-227; 1999.

 

  1. Severson, J.L., and K. Tyring. Relation between herpes simplex viruses and human immunodeficiency virus infections. Arch. Dermatol. 135:1393-1397; 1999.

 

  1. Richart, R.M, A. Ferenczy, K.F. Trofatter, and K. Tyring. New approaches to management of external genital warts.  Contemporary OB/Gyn. 44(10) supplement 1-22; 1999.

 

  1. Brown, T.J., A. Yen-Moore, and K. Tyring. An overview of sexually transmitted diseases Part I (bacterial STDs). J. Am. Acad. Dermatol. 41:511-529; 1999.

 

  1. Brown, T.J., A. Yen-Moore, and K. Tyring. An overview of sexually transmitted diseases Part II (viral STDs).  J. Am. Acad. Dermatol. 41:661-677; 1999.

 

  1. Czelusta, A., A. Yen-Moore, M. Vander Straten, D. Carrasco, and K. Tyring. An overview of sexually transmitted diseases Part III.  Sexually transmitted diseases in HIV infected patients.  J. Am. Acad. Dermatol. 43:409-432; 2000.

 

  1. Tyring, S.K., Human papillomavirus infections: epidemiology, pathogenesis and host immune response. Am. Acad. Dermatol. 43:S18-S26; 2000.

 

  1. Carrasco, D.A., C. Newman, M. Vander Straten, and K. Tyring. Treatment of viral hepatitis. Dermatologic Therapy. 13:318-325; 2000.

 

  1. Vander Straten, M.R., D. Carrasco, and K. Tyring. Treatment of human herpesvirus 8 Infections. Dermatologic Therapy. 13:277-284; 2000.

 

  1. Carrasco, D.A., M. Vander Straten, and K. Tyring. Treatment of varicella-zoster virus and postherpetic neuralgia. Dermatologic Therapy. 13:258-268; 2000.

 

  1. Carrasco, D.A., M. Vander Straten, and K. Tyring. A review of antiretroviral drugs. Dermatologic Therapy. 13:305-317; 2000.

 

  1. Yen-Moore, A., M. Vander Straten, D. Carrasco, T.Y. Evans, and K. Tyring. Cutaneous viral infections in HIV-infected individuals. Clinics in Dermatology. 18:423-432; 2000.

 

  1. Tyring, K., Immune-Response Modifiers: A New Paradigm in the Treatment of Human Papillomavirus. Current Therapeutic Research. 61: (9) 584-596; 2000.

 

  1. Vander Straten, M.R., P.C. Lee, S. Weitzul, C.J. Cockerell, and K. Tyring. Advances in the treatment of basal cell carcinoma:  The promise of pharmacological therapy.  Advances in Dermatology. 16: 299-318; 2000.

 

  1. Brown, T.J., M. Vander Straten, and K. Tyring. Antiviral agents.  Dermatol. Clinics.  19: 23-34; 2001.

 

  1. Severson, J., T. Evans, P. Lee, T. Chan, I. Arany, and K. Tyring. Human papillomavirus infections: epidemiology, pathogenesis, and therapy.  J. Cut. Med. Surg. 5: 43-60; 2001.

 

  1. Payne, D., M. Vander Straten, D. Carrasco, and K. Tyring. Molecular diagnosis of skin-associated infectious agents.  Arch. Dermatol. 137: 1497-1502; 2001.

 

  1. Carrasco, D., and K. Tyring. Advances in HIV treatment and treatment toxicities.  Dermatol. Clinics 19: 757-771; 2001.

 

  1. Carrasco, D., and K. Tyring. A review of antibiotics in dermatology.  J. Cutan. Med. Surg. 6: 128-150;2002..

 

  1. Vander Straten, M., D. Carrasco, P. Lee, and K. Tyring. Reduction of postherpetic neuralgia in herpes zoster.  J. Cutan. Med. Surg.  5: 409-416; 2001.

 

  1. Moore, T. O., A. Yen-Moore, D. Carrasco, M. Vander Straten, I. Arany, W. Au, and K. Tyring. Human papillomavirus, smoking and cancer.  J. Cutan. Med. Surg.  5:323-328; 2001.

 

  1. Vander Straten, M., D. Carrasco, P. Lee, and K. Tyring. A review of antiviral therapy for herpes labialis.  Arch. Dermatol.   137: 1232-1235; 2001.

 

  1. Vander Straten, M., and K. Tyring. Mucocutaneous manifestations of viral diseases  in children.  Clin. Dermatol. 20(1): 67-73; 2002.

 

  1. Hengge, U.R., T. Ruzicka, K. Tyring, M. Stuschke, M. Roggendorf, R.A. Schartz, and S. Seeber.  Update on Kaposi’s sarcoma and other HHV8 associated diseases.  Part 1:  epidemiology, environmental predispositions, clinical manifestations, and therapy.  Lancet Infect. Dis. 2(5): 281-292; 2002.

 

  1. Hengge, U.R., T. Ruzicka, K. Tyring, M. Stuschke, M. Roggendorf, R.A. Schartz, and S. Seeber.  Update on Kaposi’s sarcoma and other HHV8 associated diseases.  Part 2:  pathogenesis, Castleman’s disease, and pleural effusion lymphoma. Lancet Infect. Dis. 2(6): 344-352; 2002.

 

  1. Perna, A.G., and K. Tyring. A review of the dermatologic manifestations of poxvirus infections.  Dermatol. Clin.  20(2); 343-346; 2002.

 

  1. Brentjens, M.H., K.A. Yeung-Yue, P.C. Lee, and K. Tyring. Human papillomavirus: a review.  Dermatol. Clin. 20(2): 315-331;2002.

 

  1. Martinelli, P.T., and K. Tyring. Human herpesvirus 8.  Dermatol. Clin. (20(2): 307-314;2002.

 

  1. Khoshnevis, M., and K. Tyring. Cytomegalovirus infections.  Dermatol. Clin. 20(2): 291-299; 2002.

 

  1. Ikediobi, N.I., and K. Tyring. Cutaneous manifestations of Epstein-Barr virus infection.  Dermatol. Clin. 20(2): 283-289; 2002.

 

  1. Yeung-Yue, K.A., M.H. Brentjens, P.C. Lee, and K. Tyring. Herpes simplex viruses 1 and 2.  Dermatol. Clin. 20(2): 249-266; 2002.

 

  1. Jones, A.M., K. Warken, and K. Tyring. The cutaneous manifestations of viral hepatitis.  Dermatol. Clin. 20(2): 233-247; 2002.

 

  1. Vander Straten, M., and K. Tyring. Rubella.  Dermatol. Clin. 20(2): 225-231; 2002.

 

  1. Garman, M.E., and K. Tyring. The cutaneous manifestations of HIV infection.  Dermatol. Clin. 20(2): 193-208.

 

  1. Yeung-Yue, K.A., M.H. Brentjens, P.C. Lee, and K. Tyring. The management of herpes simplex virus infections.   Curr. Opin. Infect. Dis. 15(2): 115-122; 2002.

 

  1. Tyring, S.K., Baker, and W. Snowden. Valacyclovir for herpes simplex virus infection:  long-term safety and sustained efficacy after 20 years’ experience with acyclovir.  J. Infect. Dis. 186 Suppl 1:S40-46; 2002.

 

  1. Brown, T.J., M. McCrary, and K. Tyring. Antiviral agents: Nonantiretroviral drugs.  J. Am. Acad. Dermatol. 47(4):581-599; 2002.

 

  1. K. Tyring, M. Conant, M. Marini, W. Van der Meijden, and K. Washenik. Imiquimod:  an international update on therapeutic uses in dermatology.  Int. J. Dermatol.  41 :  810-816 ; 2002.

 

  1. Geraminejad, P., O. Memar, I. Aronson, P.L. Rady, U. Hengge, and K. Tyring. Kaposi’s sarcoma and other manifestations of human herpesvirus 8.  J. Am. Acad. Dermatol.  47: 641-655; 2002.

 

  1. Roncalli, W., C.F. Neto, and K. Tyring. Aspectos clinicos da epidermodisplasia verruciforme.  An. Bras. Dermatol.  77: 545-556; 2002.

 

  1. Wu, J., M.H. Brentjens, G. Torres, K. Yeung-Yue, P. Lee, and K. Tyring. Valacyclovir for the therapy of genital herpes, herpes zoster and other viral infections.  J. Cutan. Med. Surg. 7: 372-381; 2003.

 

  1. Lin, P., G. Torres, and K. Tyring. Changing paradigms in dermatology: antivirals in dermatology. Clin. Dermatol. 21: 426-446; 2003.

 

  1. Lupi, O. and S.K. Tyring. Tropical dermatology: viral tropical diseases. Am. Acad. Dermatol. 49: 979-1002; 2003.

 

  1. Brentjens, M.H., K. Sra, G. Torres, P.C. Lee and K. Tyring. Advances in the development of new vaccines for bacterial and viral diseases. Adv. Dermatol. 19: 73-112; 2003.

 

  1. Tyring, S.K. Vulvar squamous cell carcinoma: guidelines for early diagnosis and treatment. J. Obstet. Gynecol. 189: S17-23; 2003.

 

  1. Tyring, S. Molluscum contagiosum: the importance of early diagnosis and treatment. Am J. Obstet. Gynecol. 189: S12-16; 2003.

 

  1. Wu, J.J. and K. Tyring. The academic strength of current dermatology residency applicants. Dermatol. Online J. 9: 22; 2003.

 

  1. Wu, J.J. and K. Tyring. The esprit de corps of dermatology residents. Dermatol. Online J. 9: 21; 2003.

 

  1. Brentjens, M.H., K.A. Yeung-Yue, P.C. Lee and K. Tyring. Recurrent genital herpes treatments and their impact on quality of life. Pharmacoenonomics 21: 853-863; 2003.

 

  1. Hengge, U.R., A. Tannapfel, K. Tyring, R. Erbel, G. Arendt and T. Ruzicka. Lyme borreliosis. Lancet Infect. Dis. 3: 489-500; 2003.

 

  1. Brentjens, M.H., K.A. Yeung-Yue, P.C. Lee and K. Tyring. Vaccines for viral diseases with dermatologic manifestations. Dermatol. Clin. 21: 349-369; 2003.

 

  1. Torres, G., M. Schinstine, P. Krusinski and K. Tyring. Herpes simplex. eMedicine J.4: 1-16; 2003.

 

  1. Wu, J., D. Huang, K. Pang and K. Tyring. Vaccines and immunotherapies for the prevention of infectious diseases having cutaneous manifestations. J. Am. Acad. Dermatol. 50: 495-528; 2004.

 

  1. Kim, W., H. Erlandsen, S. Surendran, R.C. Stevens, A. Gamez, K. Michols-Matalon, K. Tyring and R. Matalon. Trends in enzyme therapy for phenylketonuria. Mol Ther 10: 220-224; 2004.

 

  1. Huang, D.B., J.J. Wu, and K.Tyring. Viral vaccines: A review of the recent advances in the development of current and investigational viral vaccines. J. Infect. 49:179-209; 2004.

 

  1. Wu, J.J., D.B. Huang and K. Tyring. Resiquimod: a new immune response modifier with potential as vaccine adjuvant for Th1 immune responses. Antiviral Res 64: 79-83; 2004.

 

  1. Chakrabarty, A., K. Tyring, K. Beutner and M. Rauser. Recent clinical experience with famciclovir—a “third generation” nucleoside prodrug. Antivir Chem Chemother 15: 251-253; 2004.

 

  1. Jogi, R. and K. Tyring. Therapy of nontuberculous mycobacterial infections. Dermatol Ther. 17: 491-498; 2004.

 

  1. Chang, Y.C. and K. Tyring. Therapy of HIV infection. Dermatol Ther. 17: 449-464; 2004.

 

  1. Rivera, A. and K. Tyring. Therapy of cutaneous human papillomavirus infections. Dermatol Ther. 17: 441-448; 2004.

 

  1. Chakrabarty, A., K.R. Pang, J.J. Wu, J. Narvaez, M. Rauser, D.B. Huang, K.R. Beutner and K. Tyring. Emerging therapies for herpes viral infections (types 1-8). Expert Opin Emerg Drugs. 9: 237-256; 2004.

 

  1. Sra, K.K. and K. Tyring. Treatment of postherpetic neuralgia. Skin Therapy Lett. 9:1-4; 2004.

 

  1. Pang, K.R., J.J. Wu, D.B. Huang and K. Tyring. Subcutaneous fungal infections. Dermatol Ther. 17: 523-531; 2004.

 

  1. Wu, J.J., K.R. Pang, D.B. Huang and K. Tyring. Therapy of systemic fungal infections. Dermatol Ther. 17: 532-538; 2004.

 

  1. Huang, D.B., L. Ostrosky-Zeichner, J.J. Wu, K.R. Pang and K. Tyring. Therapy of common superficial fungal infections. Dermatol Ther. 17: 517-522; 2004.

 

  1. Sra, K.K., J. Sracic and K. Tyring. Treatment of protozoan infections. Dermatol Ther. 17: 513-516; 2004.

 

  1. Maender, J.L. and K. Tyring. Treatment and prevention of rickettsial and ehrlichial infections. Dermatol Ther. 17: 499-504; 2004.

 

  1. Wu, J.J., D.B. Huang, K.R. Pang and K. Tyring. Selected sexually transmitted diseases and their relationship to HIV. Clin Dermatol 22: 499-508; 2004.

 

  1. Gupta, A.K., A.M. Cherman and K. Tyring. Viral and nonviral uses of imiquimod: A review. J Cutan Med Surg 8: 338-352; 2004.

 

  1. Sra, K.K., M. Babb-Tarbox, S. Aboutalebi, P. Rady, G.L. Shipley, D.D. Dao and K. Tyring. Molecular diagnosis of cutaneous diseases. Arch Dermatol 141: 225-241; 2005.

 

  1. Chakrabarty, A., N.J. Anderson, K. Beutner and K. Tyring. Valacyclovir for the management of herpes viral infections. Skin Therapy Lett. 10: 1-4; 2005.

 

  1. Wu, J.J., K.R. Pang, D.B. Huang and K. Tyring. Advances in antiviral therapy. Dermatol Clin 23: 313-322; 2005.

 

  1. Wu, J., D. Huang, K. Pang, S. Hsu and K. Tyring. Thalidomide: dermatological indications, mechanisms of action and side-effects. Br. J. Dermatol 153: 254-273: 2005.

 

  1. Pang, K.R., J.J. Wu, D.B. Huang, K. Tyring and S. Baron. Biological and clinical basis for molecular studies of interferons. Methods Mol. Med. 116: 1-23; 2005.

 

  1. Chang, C.C., V. Madkan, R. Cook-Norris, K. Sra and K. Tyring. Current and potential uses of imiquimod. South. Med. J. 98: 914-920; 2005.

 

  1. Sra, K., G. Torres, P. Rady, T.K. Hughes, D.A. Payne and K. Tyring. Molecular diagnosis of infectious diseases in dermatology. J. Am. Acad. Dermatol. 53: 749-765; 2005.

 

  1. Wu, J.J., D.B. Huang, K.R. Pang and K. Tyring. Rickettsial infections around the world, Part 1: Pathophysiology and the spotted fever group. J Cutan Med Surg 9: 54-62; 2005.

 

  1. Wu, J.J., D.B. Huang, K.R. Pang and K. Tyring. Rickettsial infections around the world, Part 2: Rickettsialpox, the typhus group, and bioterrorism. J. Cutan Med Surg 9: 105-115; 2005.

 

  1. Madkan, V.K., A.A. Giancola, K.K. Sra and K. Tyring. Sex differences in the transmission, prevention and disease manifestations of sexually transmitted diseases. Arch. Dermatol. 142: 365-370; 2006. (commentary in JAMA 295: 1443-1445; 2006).

 

  1. Lupi, O., K. Tyring and M.R. McGinnis. Tropical dermatology: fungal diseases. J. Am. Acad. Dermatol. 53: 931-951; 2005.

 

  1. Lupi, O., V. Madkan and K. Tyring. Tropical dermatology: Bacterial tropical diseases. J. Am. Acad. Dermatol. 54: 559-578; 2006.

 

  1. Hull, C., S. Spruance, K. Tyring and K. Hamed. Single-dose famciclovir for the treatment of herpes labialis. Curr. Med. Res. Opin. 22: 1699-1702; 2006.

 

  1. Chiao, E., T. Giordano, J. Palefsky, K. Tyring and H. El Seray. Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin. Infect. Dis. 43: 223-233; 2006.

 

  1. Brantley, J.S., L. Hicks, K. Sra and K. Tyring. Valacyclovir for the treatment of genital herpes. Expert Rev Anti Infect Ther. 4: 367-376; 2006.

 

  1. Ahmed, A.M., V. Madkan and K. Tyring. Human papillomaviruses and genital disease. Dermatol Clin. 24: 157-165; 2006.

 

  1. Berman, B., L. Bienstock, L. Kuritzky, E.J. Mayeaux Jr. and K. Tyring. Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel. J. Fam Pract. 55: suppl. 1-8; 2006.

 

  1. Speck, L.M. and K. Tyring. Vaccines for the prevention of human papillomavirus infections. Skin Therapy Lett. 11: 1-3; 2006.

 

  1. Tyring, S., Berger, A. Yen-Moore, M. Tharp and K. Hamed. Single-day therapy for recurrent genital herpes. Am J Clin Dermatol. 7: 209-211; 2006.

 

  1. Dworkin, R.H., R.W. Johnson, J. Breuer, J.W. Gnann, M.J. Levin, M. Backonja, R.F. Betts, A.A. Gershon, M.L. Haanpaa, M.W. McKendrick, T.J. Nurmikko, A.L. Oaklander, M.N. Oxman, D. Pavan-Langston, K.L. Petersen, M.C. Rowbotham, K.E. Schmader, B.R. Stacey, K. Tyring, A.J. van Wijck, M.S. Wallace, S.W. Wassilew and R.J. Whitley. Recommendations for the management of herpes zoster. Clin. Infect. Dis. 44 (Suppl 1): S1-S26; 2007.

 

  1. Tyring, S.K., Richwald and K. Hamed. Single-day therapy: an expert opinion on a recent development for the episodic treatment of recurrent genital herpes. Arch. Gynecol. Obstet. 275: 1-3; 2007.

 

  1. Wu, J.J., K. Tyring. Patients seen and lessons learned. Clin Dermatol. 25: 144-145; 2007.

 

  1. Madkan, V.K., R.H. Cook-Norris, M.C. Steadman, A. Arora, N. Mendoza, K. Tyring. The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors. Br J Dermatol. 157: 228-241; 2007.

 

  1. Arora, A.E. Chiao, K. Tyring. AIDS malignancies. Cancer Treat Res. 133: 21-67; 2007.

 

  1. Ahmed, A.M., J.S. Brantley, V. Madkan, N. Mendoza, K. Tyring. Managing herpes zoster in immunocompromised patients. Herpes. 14: 32-36; 2007.

 

  1. Bartlett, B.L., M. Khambaty, N. Mendoza, A.M. Tremaine, A. Gewirtzman, K. Tyring. Dermatological management of human immunodeficiency virus (HIV). Skin Therapy Lett. 12: 1-3; 2007.

 

  1. Tyring, S.K. Management of herpes zoster and postherpetic neuralgia. J Am Acad Dermatol. 57: S136-142; 2007.

 

  1. Gewirtzman, A.B. Bartlett, K. Tyring. Epidermodysplasia verruciformis and human papilloma virus. Curr Opin Infect Dis. 21: 141-146; 2008.

 

  1. Galindo, M.P., B.L. Bartlett, A. Gewirtzman, N. Mendoza, A.M. Tremaine, K. Tyring. Etanercept: an overview of its role in the treatment of psoriasis. Expert Opin Drug Metab Toxicol. 4: 305-310; 2008.

 

  1. Bartlett, B.L., K. Tyring. Ustekinumab for chronic plaque psoriasis. Lancet. 371: 1639-1640; 2008.

 

  1. Bartlett, B.L., K. Tyring, K. Fife, J.W. Gnann, Jr., J.T. Hadala, F. Kianifard, E. Berber. Famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the RELIEF trial. J Clin Virol. 43: 190-195; 2008.

 

  1. Mendoza, N., M. Diamantis, A. Arora, B. Bartlett, A. Gewirtzman, A.M. Tremaine, Tyring. Mucocutaneous manifestations of Epstein-Barr virus infection. Am J Clin Dermatol. 9: 295-305; 2008.

 

  1. Modi, S., L. Van, A. Gewirtzman, N. Mendoza, B. Bartlett, A.M. Tremaine, Tyring. Single-day treatment for orolabial and genital herpes: a brief review of pathogenesis and pharmacology. Ther Clin Risk Manag. 4: 409-417; 2008.

 

  1. Bartlett, B.L., M.N. Moody, K. Tyring. IL-12/IL-23 Inhibitors: The Advantages and Disadvantages of this Novel Approach for the Treatment of Psoriasis. Skin Therapy Lett. 13: 1-4; 2008.

 

  1. Bartlett, B.L., K. Tyring. Vaccines for the prevention of infectious diseases with mucocutaneous manifestations. Dermatol Ther. 22: 95-96; 2009.

 

  1. Bartlett, B.L., K. Tyring. Safety and efficacy of vaccines. Dermatol Ther. 22: 97-103; 2009.

 

  1. Bartlett, B.L., A.J. Pellicane, K. Tyring. Vaccine immunology. Dermatol Ther. 22: 104-109; 2009.

 

  1. Conner, K., A. Wuu, V. Maldonado, B.L. Bartlett,K. Tyring. Vaccines under study: non-HIV vaccines. Dermatol Ther. 22: 168-185; 2009.

 

  1. Lupi, O., B.L. Bartlett, R.N. Haugen, L.C. Dy, A. Sethi, S.N. Klaus, J. Machado Pinto, F. Bravo, K. Tyring. Tropical dermatology: Tropical diseases caused by protozoa. J Am Acad Dermatol. 60: 897-925; 2009.

 

  1. Gaspari, A.A., K. Tyring, T. Rosen. Beyond a decade of 5% imiquimod topical therapy. J Drugs Dermatol. 8: 467-474; 2009.

 

  1. Diamantis, M.L., B.L. Bartlett and K. Tyring. Safety, efficacy & recurrence rates of imiquimod cream 5% for treatment of anogenital warts.  Skin Therapy Lett. 14:1-3; 2009.

 

  1. Wu, J.J., K.F. Davis, C.C. Ramirez, C.A. Alonzo, B. Berman and K. Tyring. Graduates-of-foreign-dermatology residencies and military dermatology residencies and women in academic dermatology.  Dermatol Online J. 15:2; 2009.

 

  1. Haddad Jr., V., O. Lupi, J.P. Lonza and S.K. Tyring. Tropical dermatology: marine and aquatic dermatology. J Am Acad Dermatol. 61:733-752; 2009.

 

  1. Mendoza, N., A. Li, A. Gill and S.K. Tyring. Filariasis: diagnosis and treatment. Dermatol Ther. 22:475-490; 2009.

 

  1. Satyaprakash, A.K. and K. Tyring. Human papillomaviruses vaccine: a dermatologic perspective.  Indian J Dermatol Venereol Leprol. 76:14-19; 2010.

 

  1. Moody, M.N., L.K. Morrison and S.K. Tyring. Retapamulin: what is the role of this topical antimicrobial in the treatment of bacterial infections in atopic dermatitis? Skin Therapy Lett. 15:1-4; 2010.

 

  1. Willison, C.B., L.K. Morrison, N. Mendoza and K. Tyring. Shingles vaccine. Expert Opin Biol Ther. 10:631-638; 2010.

 

  1. Mendoza, N and K. Tyring. Emerging drugs for complicated skin and skin-structure infections.  Expert Opin Emerg Drugs. 15:509-520; 2010.

 

  1. Morrison, L.K., R. Rapini, C.B. Willison and K. Tyring. Infection and panniculitis.  Dermatol Ther. 23:328-340; 2010

 

  1. Weinberg, J.M. and K. Tyring. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus.     J Drugs Dermatol. 9:1198-1204; 2010.

 

  1. Patel, T., L.K. Morrison, P. Rady and K. Tyring. Epidermodysplasia verruciformis and susceptibility to HPV.  Dis Markers. 29:199-206; 2010.

 

  1. Magel, G.D., N. Mendoza, C.M. DiGiorgio, K.A. Heitz, W.J. LaPolla and K. Tyring. Vaccines in dermatological diseases.  G Ital Dermatol Venereol. 146:225-233; 2011.

 

  1. Mendoza, N., P.O. Hernandez and K. Tyring. HPV vaccine update: new indications and controversies. Skin Therapy Lett. 16:1-3; 2011.

 

  1. Javed, S., S.A. Javed and K. Tyring. Varicella vaccines.  Curr Opin Infect Dis. 2011.

 

  1. Sri, J.C., M.I. Dubina, G.F. Kao, P.L. Rady, K. Tyring and A.A. Gaspari. Generalized verrucosis: a review of the associated diseases, evaluation, and treatments.  J Am Acad Dermatol. 66:292-311; 2012.

 

  1. Rosen, R.H., A.K. Gupta and K. Tyring. Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: Rapid lesion necrosis followed by lesion-specific immune response.  J Am Acad Dermatol. 66:486-493; 2012.

 

  1. Hernandez, P.O., S. Lema, K. Tyring and N. Mendoza. Ceftaroline in complicated skin and skin-structure infections. Infect Drug Resist. 5:23-35; 2012.

 

  1. Haddad Jr., V., J.L. Costa Cardoso, O. Lupi and K. Tyring. Tropical dermatology: venomous arthropods and human skin part 1: insecta. JAAD 67: 331-346; 2012.

 

  1. Haddad Jr., V., J.L. Costa Cardoso, O. Lupi andK. Tyring. Tropical dermatology: venomous arthropods and human skin part 2: diplopoda, chilopoda and arachnida. JAAD 67: 347-355; 2012.

 

  1. Gordon, R. R. Mays, H. Doan, W. LaPolla and K. Tyring. Biologic therapy and risk of infection. Skin Therapy Lett 17:1-4; 2012.

 

  1. Chon, S.Y., H.Q. Doan, R.M. Mays, S.M. Singh, R.A. Gordon and K. Tyring. Antibiotic overuse and resistance in dermatology. Dermatol Ther 25: 55-69; 2012.

 

  1. Harpaz, R., M.A. Nagel, K. Schmader, K. Tyring and B.P. Yawn. Roundtable on postherpetic neuralgia-what, why, how long, and what’s next? Popul Health Manag 15: 385-390; 2012.

 

  1. Tyring, S.K. Vaccination of older adults against herpes zoster is safe and effective. Evid Based Med 18:e43; 2013.

 

  1. Javed, S., F. Khan, M. Ramirez-Fort and K. Tyring. Bites and mites: prevention and protection of vector-borne disease. Curr Opin Pediatr 25: 488-491; 2013.

 

  1. Doan, H.Q., B. Ung, M.K. Ramirez-Fort, F. Khan and K. Tyring. Zostavax: a subcutaneous vaccine for the prevention of herpes zoster. Expert Opin Biol Ther 13: 1467-1477; 2013.

 

  1. Downing, C., J. Moayyad, A. Tamirisa and K. Tyring. Acyclovir lauriad: a muco-adhesive buccal tablet for the treatment of recurrent herpes labialis. Expert Rev Anti Infect Ther 12: 283-287; 2014.

 

  1. Kim, S.R., F. Khan, M.K. Ramirez-Fort, C. Downing and K. Tyring. Varicella zoster: an update on current treatment options and future perspectives. Expert Opin Pharmacother 15: 61-71; 2014.

 

  1. Nguyen, H.P. and K. Tyring. An update on the clinical management of cutaneous molluscum contagiosum. Skin Therapy Lett 19:5-8; 2014.

 

  1. Tausend, W., C. Downing and K. Tyring. Systematic review of interleukin-12, interleukin-17 and interleukin-23 pathway inhibitors for the treatment of moderate-to-severe chronic plaque psoriasis: ustekinumab, brikinumab, tildrakizumab, guselkumab, secukinumab, ixekizumab and brodalumab. J Cutan Med Surg 18: 156-169; 2014.

 

  1. Downing, C., M.K. Ramirez-Fort, H.Q. Doan, F. Benoist, M.S. Oberste, F. Khan and K. Tyring. Coxsackievirus A6 associated hand, foot and mouth disease in adults: clinical presentation and review of the literature. J Clin Virol 60: 381-386; 2014.

 

  1. Kollipara, R., C. Downing, M. Lee, J. Guidry, S. Curtis and K. Tyring. Current and emerging drugs for acute bacterial skin and skin structure infections: an update. Expert Opin Emerg Drugs 19: 431-440; 2014.

 

  1. Nguyen, H.P., E. Franz, K.R. Stiegel, S. Hsu and K. Tyring. Treatment of molluscum contagiosum in adult, pediatric and immunodeficient populations. J Cutan Med Surg 18: 299-306; 2014.

 

  1. Kollipara, R., C. Downing, R. Gordon and K. Tyring. Interleukin-23 in the pathogenesis and treatment of psoriasis. Skin Therapy Lett 20: 1-4; 2015.

 

  1. Reusser, N.M., C. Downing, J. Guidry and K. Tyring. HPV carcinomas in immunocompromised patients. J Clin Med 4: 260-281; 2015.

 

  1. Kash, N., M.A. Lee, R. Kollipara, C. Downing, J. Guidry and K. Tyring. Safety and efficacy data on vaccines and immunization to human papillomavirus. J Clin Med 4: 616-633; 2015.

 

  1. Kollipara, R., E. Ekhlassi, C. Downing, J. Guidry, M. Lee and K. Tyring. Advancements in pharmacotherapy for noncancerous manifestations of HPV. J Clin Med 4: 832-846; 2015.

 

  1. Zeitlin, R., H.P. Nguyen, D. Rafferty and K. Tyring. Advancements in the management of HPV-associated head and neck squamous cell carcinoma. J Clin Med 4: 822-831; 2015.

 

  1. Chockalingam, R., C. Downing and K. Tyring. Cutaneous squamous cell carcinomas in organ transplant recipients. J Clin Med 4: 1229-1239; 2015.

 

  1. Guidry, J.A., C. Downing and K. Tyring. Blastomycosis-like infections, pyoderma and granulomatous sexually transmitted infections. Dermatol Clin 33: 595-607; 2015.

 

  1. Gaspari, A.A. and K. Tyring. New and emerging biologic therapies for moderate-to-severe plaque psoriasis: mechanistic rationales and recent clinical data for IL-17 and IL-23 inhibitors. Dermatol Ther 28: 179-193; 2015.

 

  1. Lupi, O., C. Downing, M. Lee, L. Pino, F. Bravo, P. Giglio, A. Sethi, S. Klaus, O.P. Sangueza, C. Fuller, N. Mendoza, B. Ladizinski, L. Woc-Colburn and K. Tyring. Mucocutaneous manifestations of helminth infections: Nematodes. J Am Acad Dermatol 73: 929-944; 2015.

 

  1. Lupi, O., C. Downing, M. Lee, F. Bravo, P. Giglio, L. Woc-Colburn and K. Tyring. Mucocutaneous manifestations of helminth infections: Trematodes and Cestodes. J Am Acad Dermatol 73: 947-957; 2015.

 

  1. Nawas, Z.Y., Y. Tong, R. Kollipara, A.J. Peranteau, L. Woc-Colburn, A.C. Yan, O. Lupi and S.K. Tyring. Emerging infectious diseases with cutaneous manifestations: Viral and bacterial infections. J Am Acad Dermatol. 75:1-16; 2016.

 

 

  1. Kollipara, R., A.J. Peranteau, Z.T.Nawas, Y. Tong, L. Woc-Colburn, A.C. Yan, O. Lupi and K. Tyring. Emerging infectious diseases with cutaneous manifestations: Fungal, helminthic, protozoan and ectoparasitic infections. J Am Acad Dermatol. 75:19-30; 2016.

 

  1. Peranteau, A.J., A.E.Turkeltaub, Y. Tong, Z. Nawas and K.Tyring. A Review of Ixekizumab, an Anti-Interleukin-17A Monoclonal Antibody, for Moderate-to-Severe Plaque Psoriasis. Skin Therapy Lett. 21:1-6; 2016.

 

  1. Chahoud, J., A.G. Rieber and K. Tyring. The β-HPV Subtypes-Cornerstone of the Next-Generation Vaccine. JAMA Oncol. doi: 10.1001/jamaoncol.3415; 2016.

 

 

  1. Nawas, Z., M. Hatch, E. Ramos, M. Liu, Y. Tong, A. Peranteau and K. Tyring. A Review of Guselkumab, an IL-23 Inhibitor, for Moderate-to-Severe Plaque Psoriasis. Skin Therapy Lett. 22:8-10: 2017.

 

  1. Tong, Y., A.J. Peranteau, Z. Nawas and K. Tyring.

A Review of Brodalumab, an IL-17 Receptor Antagonist, for Moderate-to-Severe Plaque Psoriasis. Skin Therapy Lett. 22:1-6; 2017.

 

 

 

 

 

 

 

  1. CASE REPORTS

 

  1. Tyring, S., and P. Lee. Hemorrhagic bullae associated with Vibrio vulnificus Arch. Dermatol. 122:818-820; 1986.

 

  1. Soong, V., P.C. Lee, R.B. Kissel, W.M. Sams, and K. Tyring. Fatal malignant melanoma associated with a completely regressed primary melanoma in a patient with cutaneous T cell lymphoma. Arch. Dermatol.  123:1270-1272; 1987.

 

  1. Tyring, S.K., P.C. Lee, E. Omura, L.K. Green, and Y. Merot. Recurrent and metastatic cutaneous neuroendocrine (Merkel cell) carcinoma mimicking angiosarcoma. Dermatol. 123:1368-1370; 1987.

 

  1. Tyring, S.K., P. Downing, and P. Poffenbarger. Progression of an insulin-insensitive variety of combined types A and B diabetes mellitus to systemic lupus erythematosus. Med. J. 80:641-644; 1987.

 

  1. Jones, C.S., K. Tyring, P.C. Lee, and J.D. Fine. Development of neuroendocrine (“Merkel cell”) carcinoma mixed with squamous cell carcinoma in erythema ab igne. Arch. Dermatol. 124:110-113; 1988.

 

  1. Tyring, S.K., C.S. Jones, P.C. Lee, and J.D. Fine. Development of verrucous plaques and gross hematuria in advanced cutaneous T cell lymphoma. Dermatol. 124:655-657; 1988.

 

  1. Appell, M.L., W.Q. Ward, and K. Tyring. Erythema gyratum repens: A cutaneous marker of malignancy. Cancer 62:548-550; 1988.

 

  1. Tyring, S.K., P. Guest, P. Lee, K. Jaffe, W. Little, and R. Pritchett. Epithelioid hemangioendothelioma of the skin and femur. Am. Acad. Dermatol. 20:362-366; 1989.

 

  1. Beightler, E.L. and K. Tyring. The use of isotretinoin in a renal hemodialysis patient. J. Am. Acad. Dermatol. 23:758; 1990.

 

  1. Tyring, S.K. Carcinoma of the cervix with invasion of the vulva. J. Am. Acad. Dermatol. 23:961-968; 1990.

 

  1. Newman, C., S. Dozier, D. Diven, and K. Tyring. Persistent oral and vaginal ulcerations in a Hispanic female. Arch. Otolaryngol. Head Neck Surg. 117:686-689; 1991.

 

  1. Pupo, R.A., K. Tyring, and S.S. Raimer. Omenn’s syndrome: A diagnostic consideration in infants with persistent erythroderma and failure to thrive. J. Am. Acad. Dermatol. 25:442-446; 1991.

 

  1. Griffin, D., E.L. Beightler, and K. Tyring. Lepromatous leprosy mimicking porphyria cutanea tarda. Int. J. Dermatol. 30:578-580; 1991.

 

  1. Purvis, R.S., E.L. Beightler, D.G. Diven, R.L. Sanchez, and K. Tyring. Strongyloides hyperinfection presenting with petechiae and purpura. Int. J. Dermatol. 31:169-171; 1992.

 

  1. Newman, C., M. Shepherd, M.D. Woodard, A.K. Chopra, and K. Tyring. Fatal septicemia and bullae caused by non-01 Vibrio cholerae. J. Am. Acad. Dermatol. 29:909-912; 1993.

 

  1. Purvis, R.S., D.G. Diven, K. Tyring, R.D. Drechsel, and J.M. Calhoun. Sporotrichosis presenting as arthritis with subcutaneous nodules. J. Am. Acad. Dermatol. 28:879-884; 1993.

 

  1. Doherty, M.G., T. Van Dinh, D. Payne, K. Tyring, and E.V. Hannigan. Chronic plasma cell cervicitis simulating a cervical malignancy. Obstet. Gynecol. 82:646-650; 1993.

 

  1. Purvis, R.S., and Tyring. Cutaneous and subcutaneous endometriosis: Surgical and hormonal therapy. J. Dermatol. Surg. Oncol. 20:693-695; 1994.

 

  1. Yen, A., R.C. Knipe, and K. Tyring. Primary cutaneous blastomycosis: report of a case acquired by direct inoculation of a bullous pemphigoid lesion. J. Am. Acad. Dermatol. 31:277-278; 1994.

 

  1. Yen, A., P. Fearneyhough, P. Rady, Tyring, and D. Diven. Erythema induratum of Bazin as a tuberculid. J. Am. Acad. Dermatol. 36:99-101; 1997.

 

  1. Driscoll, M.S., and K. Tyring. Development of resistance to clarithromycin after treatment of cutaneous Mycobacterium chelonae infection. J. Am. Acad. Dermatol. 36:495-496; 1997.

 

  1. Chen, S.H., T.L. Evans, K. Chopra, S.S. Raimer, M.L. Levy, and K. Tyring. Herpes gestationis in a mother and child. J. Am. Acad. Dermatol. 40:847-849; 1999.

 

  1. Chopra, K.F., T.L. Evans, J. Severson, and K. Tyring. Acute varicella zoster with post-herpetic hyperhidrosis as the initial presentation of the human immunodeficiency virus infection. J. Am. Acad. Dermatol. 41:119-121; 1999.

 

  1. Ho, J., D.G. Diven, P.J.Butler, and K. Tyring. An Ulcerating Verrucous Plaque on the Foot.  Arch. Dermatol. 136:547-552; 2000.

 

  1. High, W.A., K. Tyring and R.S. Taylor. Rapidly enlarging growth of the proximal nail fold. Dermatol. Surg. 29: 984-986; 2003.

 

  1. Gupta, S. A. Jain, C. Gardiner and K. Tyring. A rare case of disseminated cutaneous zoster in an immunocompetent patient. BMC Family Practice 6:50- ; 2005.

 

  1. Wu, J.J., D.B. Huang and K. Tyring. Postherpetic poliosis. Arch. Dermatol. 142: 250-251; 2006.

 

  1. Wu, J.J., D.B. Huang, C. Woodruff and K. Tyring. An unusual presentation of two simultaneous primary melanomas. Int J Dermatol. 45: 580-582; 2006.

 

  1. Wu, J.J., D.B. Huang, K.R. Pang and K. Tyring. Cutaneous metastasis to the chest wall from prostate cancer. Int J Dermatol. 45: 946-948; 2006.

 

  1. Wu, J.J., D.B. Huang and K. Tyring. West Nile virus rash on the palms and soles of the feet. JEADV 20: 1393-1394; 2006.

 

  1. Wu, J.J., J.E. Murase, D.B. Huang and K. Tyring. A unique pattern of hyperhidrosis and herpes zoster. Arch Dermatol. 142: 1069; 2006.

 

  1. Gober, M.D., P.L. Rady, Q. He, S.B. Tucker, K. Tyring, A.A. Gaspari. Novel homozygous frameshift mutation of EVER1 gene in an epidermodysplasia verruciformis patient. J Invest Dermatol. 127: 817-820; 2007.

 

  1. Sanclemente, G., J. Garcia, L.F. Gomez, S.K. Tyring, J.C. Wolff, L.A. Correa, P. Rady. An unusual presentation of human papillomavirus (HPV) infection in a black epidermodysplasia verruciformis (EV) patient. Int J Dermatol. 46: 199-201; 2007.

 

  1. Berthelot, C., M.C. Dickerson, P. Rady, Q. He, F. Niroomand, K. Tyring, A.G. Pandya. Treatment of a patient with epidermodysplasia verruciformis carrying a novel EVER2 mutation with imiquimod. J Am Acad Dermatol. 56:882-886; 2007.

 

  1. Cohen, P.R., K.E. Schulze, P.L. Rady, K. Tyring, Q. He, P.T. Martinelli, B.R. Nelson. Coincidental consort clear cell cutaneous carcinoma: facial squamous cell carcinoma in situ containing human papillomavirus and cancer cells with clear cytoplasm in an octogenarian couple. South Med J. 100: 525-530; 2007.

 

  1. Foong, H.B., O.A. Ibrahimi, D.J. Elpern, Tyring, P. Rady, J.A. Carlson. Multiple facial seborrheic keratosis-like lesions in a young woman with epidermodysplasia verruciformis. Int J Dermatol. 47: 476-478; 2008.

 

  1. Burdett, C., N. Mendoza, A. Arora, B. Bartlett, A. Gewirtzman, A.M. Tremaine, Tyring. A rare case of disseminated shingles in an immunocompetent patient following a 7-day treatment with oral valacyclovir. J Clin Virol. 43: 233-235; 2008.

 

  1. Hohenstein, E., P.L. Rady, M. Hergersberg, A.R, Huber, K. Tyring, T. Bregenzer, M. Streit, P. Itin. Epidermodysplasia verruciformis in a HIV-positive patient homozygous for the c917AàT polymorphism in the TMC8/EVER2 gene. Dermatology. 218: 114-118; 2009.

 

  1. Oliveira, W.R., G.N. Ferreira, P.L. Rady, C. Festa and K. Tyring. Epidermodysplasia verruciformis associated with myelodysplastic syndrome: an intriguing association.  J Cutan Med Surg. 13:317-320; 2009.

 

  1. Tremaine, A.M., D.E. Whittemore, A.J. Gewirtzman, B.L. Bartlett, N. Mendoza, R.P. Rapini, K. Tyring. An unusual case of swimmer’s itch. J Am Acad Dermatol. 60: 174-176; 2009.

 

  1. Cutlan, J.E., R.M. Rashid, C. Torres-Cabala, K. Tyring and V. Thomas. Epidermodysplasia verruciformis after cutaneous T-cell lymphoma: Periungual presentation. Dermatol Online J. 16:12; 2010.

 

  1. Halvorson, C.R., S. McClain, P. Rady, K. Tyring and A.A. Gaspari. Merkel cell carcinoma presenting in a young patient as a forme fruste of variant epidermodysplasia verruciformis. J Am Acad Dermatol. 65:667-669; 2011.

 

  1. Haitz, K.A. and K. Tyring. An HIV-Positive Male with a Herald Plaque. Clin Infect Dis. 52:779 and 825-827; 2011.

 

  1. Lapolla, W. and K. Tyring. Images in clinical medicine. Podoconiosis. N Engl J Med. 364:e23; 2011.

 

  1. Halvorson, C.R., S. McClain, P. Rady, K. Tyring and A. Gaspari. Merkel cell carcinoma presenting in a young patient as a forme fruste of variant epidermodysplasia verruciformis. J Am Acad Dermatol 65: 667-669; 2011.

 

  1. Gordon, R.A., D.A. Sutton, E.H. Thompson, V. Shrikanth, G.J. Verkley, J.B. Stielow, R. Mays, D. Oleske, L.K. Morrison, W.J. PaPolla, S. Galfione, K. Tyring, C.C. Samathanam, J. Fu, B.L. Wickes, V. Mulanovich, A. Wanger and C.A. Arias. Cutaneous phaeohyphomycosis caused by Paraconiothyrium cyclothyrioides. J Clin Microbiol 50: 3795-3798; 2012.

 

  1. Gordon, R., R.M. Mays, W. LaPolla and K. Tyring. Herpes zoster duplex bilateralis in an immunocompetent woman-is gender a risk factor? Popul Health Manag 15: 398-400; 2012.

 

  1. Haitz, K.A., P.L. Rady, H.P. Nguyen, Q. He, V.G. Prieto, K. Tyring and A.M. Ciurea. Merkel cell polyomavirus DNA detection in a patient with Merkel cell carcinoma and multiple other skin cancers. Int J Dermatol 51: 442-444; 2012.

 

  1. Gordon, R. and K. Tyring. Vesicular eruption. JAMA 307: 1528-1529; 2012.

 

  1. Mays, R., R. Gordon, J.M. Wilson, W.J. LaPolla, K.K. Sra, V. Madkan and K. Tyring. Persistent erythematous plaque after minor trauma in an immunocompromised woman. Dermatol Online J 18: 2; 2012.

 

  1. Introcaso, C.E., P.L. Rady, Q. He, K. Tyring and C.L. Kovarik. Human papillomavirus type 73 associated with multiple cutaneous squamous cell carcinomas in an immunosuppressed patient. Int J Dermatol 51: 713-715; 2012.

 

  1. Raghu, P., T.A. Tran, P. Rady, K. Tyring and J.A. Carlson. Ileostomy-associated chronic papillomatous dermatitis showing nevus sebaceous-like hyperplasia, HPV 16 infection and lymphedema: a case report and literature review of ostomy-associated reactive epidermal hyperplasias. Am J Dermatopathol 34:e97-102; 2012.

 

  1. Nguyen, H.P., R.A. Gordon, R.J. Hamill and K. Tyring. A polymorphic, mucocutaneous eruption in a patient with end-stage renal disese. Dermatol Online J 19: 20024; 2013.

 

  1. Mays, R.M., R.A. Gordon, K.C. Durham, W.J. LaPolla and K. Tyring. Rocky Mountain spotted fever in a patient treated with anti-TNF-alpha inhibitors. Dermatol Online J 19: 7; 2013.

 

  1. Kwon, E.K., C.R. Halvorson, P. Rady, K. Tyring, H.P. Nguyen, G.F. Kao and A.A. Gaspari. Merkel cell polyomavirus detection in a patient with familial epidermodysplasia verruciformis. Pediatr Dermatol 30: 505-507; 2013.

 

  1. Ha, K.Y. and K. Tyring. Vibrio vulnificus necrotizing fasciitis preceding herpes zoster. Proc (Bayl Univ Med Cent) 26: 55-57; 2013.

 

  1. Fernandez, K.H., P. Rady, K. Tyring and M.S. Stone. Acquired epidermodysplasia verruciformis in a child with atopic dermatitis. Pediatr Dermatol 31: 400-402; 2014.

 

  1. Downing, C. and S.K. Tyring. Erythematous popular eruption in a 7-month-old male. G Ital Dermatol Venereol 2014.

 

  1. Schlichte, M.J., C.P. Downing, M. Ramirez-Fort, R. Gordon and K. Tyring. Bloodroot associated eschar. Dermatol Online J 20: 13030; 2014.

 

  1. Downing, C.P., L. Woc-Colburn and K. Tyring. Nasal erythema and crusting after a trip to the Venezuelan rainforest. JAMA 312: 1250-1251; 2014.

 

  1. West, E.S., M.Y. Kingsbery, E.M. Mintz, A.P. Hsu, S.M. Holland, P.L. Rady, K. Tyring and M.E. Grossman. Generalized verrucosis in a patient with GATA2 deficiency. Br J Dermatol 170: 1182-1186; 2014.

 

  1. Javed, S. and K. Tyring. Treatment of molluscum contagiosum with ingenol mebutate. J Am Acad Dermatol 70: e105; 2014.

 

  1. Lee, M.A., C.P. Downing and K. Tyring. Skin and mouth lesions plus weight loss in an elderly man. JAMA 313: 514-515; 2015.

 

  1. Kollipara, R., C. Downing, M. Lee, J. Guidry, S. Robare-Stout and K. Tyring. Blistering distal dactylitis in an adult. J Cutan Med Surg 19:397-399; 2015.

 

  1. Kollipara, R. J. A. Guidry and K. Tyring. Erythematous papules and vesicles on the palms, soles and oropharynx. JAMA Dermatol 151:783-784; 2015.

 

  1. Noparstak, M., B. McDaniel, J. King, R. Kollipara, P. Rady, R.T. Brodell and S.K. Tyring. Verrucous sarcoidosis associated with human papillomavirus infection: a case report. J Am Acad Dermatol Case Reports 1:247-250; 2015.

 

 

  1. Kollipara, R., H. Vin, C.P. Downing, H.K. Neely, A.L. Haws, S.W. Curtis and K. Tyring. Genital melanoma: two cases and an overview of epidemiology and treatment. J Eur Acad Dermatol Venereol 30:706-707; 2016.

 

 

  1. Hirschman, D., J. Tacastacas, P.L. Rady, K. Tyring, K. Cooper and K. Honda. Acquired epidermodysplasia verrciformis associated with human papillomavirus type 14 in a small bowel transplanted child- a case report. Pediatr Dermatol 33:1-5; 2016.

 

  1. Kollipara, R., K. Richards, J. Tschen, L. Campbell, K. Tyring and S. Mays. Disseminated mycobacterium avium complex with cutaneous lesions. J Cutan Med Surg 20:272-274; 2016.

 

  1. Wagner, R.D., H.P. Nguyen HP and K. Tyring. Giant ulcerative lesion on the upper back: using a differential diagnosis to formulate a clinical approach. Einstein (Sao Paulo). 14(1):106-107; 2016.

 

  1. Karas, L., R. Vangipuram, S. Zahiruddin, K.G. Sharghi, A.J.Peranteau and K. Tyring. A Bumpy Course: Nodules Along a Mastectomy Scar. Am J Med. 2017 130:539-541; 2017.

 

  1. Vangipuram, R. and K. Tyring. A 55-Year-Old Man With a Painful Rash on the Sole of His Foot. JAMA. 317:851-852; 2017.

 

  1. Vangipuram, R., Y. Tong and S.K. Tyring.

A Tender Rash on the Hand. JAMA. 317:1169-1170; 2017.

 

  1. Hinojosa, T., D.J. Lewis, K.G. Sharghi, E. Ramos, R.P. Rapini and K. Tyring. Verrucous eyebrows: a cutaneous manifestation of a systemic disease. J Eur Acad Dermatol Venereol. doi: 10.1111/jdv.14246; 2017.

 

 

 

 

 

 

  1. LETTERS/EDITORIALS

 

  1. Scinicariello, F., P. Rady, M.W. Cloyd, and K. Tyring. HPV 18 in HIV-associated Kaposi’s sarcoma. Lancet 339:501; 1991.

 

  1. Baron, S., and K. Tyring. Interferons: Potential problems.  JAMA 267:509; 1992.

 

  1. Purvis, R.S., and K. Tyring. Lindane – resistant scabies. J. Am. Acad. Dermatol. 27:648; 1992.

 

  1. Martin, R.W., E.R. Farmer, P.L. Rady, and K. Tyring. Cutaneous papillary squamous cell carcinoma in an immunocompromised host. J. Cutan. Pathol.  21:476-477; 1994.

 

  1. Tyring, S.K. (Mis) treatment of acute herpes Zoster. Intern. Med. 154:2109; 1994.

 

  1. Tschen, J.A., K. Tyring, R.L. Font, and I. Arany. Paramyxovirus-like inclusions. Am. J. Dermatopathol. 17:426-427; 1995.

 

  1. Tyring, S.K. Effects of famciclovir in acute herpes zoster. Intern. Med. 124:775; 1996.

 

  1. Tyring, S.K., P. Rady, A. Yen, and T.K. Hughes. HHV8 and skin cancers in immunosuppressed patients. Lancet 347:339; 1996.

 

  1. Memar, O.M., P.L. Rady, R.M. Goldblum, A.B. West, A. Yen, and K. Tyring. Human herpesvirus 8 DNA sequences in a patient with pemphigus vulgaris, but without HIV infection or Kaposi’s sarcoma. J. Invest. Dermatol. 108:118-119; 1997.

 

  1. Tyring, S.K. Effects of famciclovir in acute herpes zoster Intern. Med. 124:775(reply); 1996.

 

  1. Tyring, S.K. No evidence of HHV8 infection in patients with pemphigus vulgaris/foliaceus.  Dermatol. 134:1162 (reply); 1998.

 

  1. Tyring, S.K., L. Saltzman, and R. Dworkin. Famciclovir and postherpetic neuralgia. Ann Intern Med. 13:712-713 (reply); 1999.

 

  1. Trizna, Z., K. Tyring, and R. Wagner. Extraordinary delayed bleeding occurring after-shave excision.  J. Am. Acad. Dermatol.  44:545; 2001.

 

  1. Kuwahara, R.T., R.B. Skinner, and K. Tyring. Direct medical cost for surgical and medical treatment of condylomata acuminata.  Arch. Dermatol. 138(4): 533; 2002.

 

  1. Wu, J.J., D.B. Huang, S. Hsu and K. Tyring. Thalidomide, semen distribution, teratogenicity and cost: reply from authors. Br. J. Dermatol. 154: 563-564; 2006.

 

  1. Lupi, O., V. Madkan and S.K. Tyring. Tropical dermatology: Bacterial tropical diseases: reply from authors. J. Am. Acad. Dermatol. 55: 1085; 2006.

 

  1. Wu, J.J., J.E. Murase, D.B. Huang and K. Tyring. A unique pattern of hyperhidrosis and herpes zoster. Arch. Dermatol. 142: 1069; 2006.

 

  1. Kollipara, R. and K. Tyring. Physician advocacy for zoster vaccination. Cutis 95: 251; 2015.

 

  1. Peranteau, A.J. and K.Tyring. Physicians must encourage HPV vaccine. Cutis. 98:354-355; 2016.

 

  1. Hatch, M.M., Z. Nawas, R. Kollipara and K. Tyring. Can curative antivirals benefit porphyria cutanea tarda in hepatitis C patients? J Eur Acad Dermatol Venereol. 31:e194; 2017.

 

 

  1. GUEST EDITOR

 

  1. Tyring, S.K. Perspectives on human papillomavirus infection. J. Med. 102 (5A):1‑43; 1997.

 

  1. Tyring, S.K. Anogenital human papillomavirus infections. Recent developments and new treatments. Australasian J. Dermatol. 39(suppl. 1); Nov. 1998.

 

  1. Tyring, S.K. Antiviral agents and the treatment of viral diseases in dermatology. Dermatologic Therapy 13 (number 3); 2000.

 

  1. Tyring, S.K. Therapy of infectious diseases in dermatology. Dermatologic Therapy 17 (number 6); 2004.

 

  1. Tyring, S.K. Clinical Advances of Human Papillomaviruses. J Clin Med 4 (Issue 5); 2015.

 

 

  1. CHAPTERS IN BOOKS

 

  1. Tyring, S., K. Klager, A. Luk, F. Messiha, and S. Lefkowitz. The effect of acute and short-term ethanol administration on interferon production in mice. In: Alcoholism: A Perspective. Eds.: Messiha and Tyner, P.J.D.  Publications, Inc. Pp. 478-490 ; 1980.

 

  1. Baron, S., Tyring, W. Fleischmann, G. Klimpel, and G. Stanton. Interferon: multiple interactions with immunity. In: Mechanisms of Lymphocyte Activation. Eds.: Resch and Kirchner.  Elsevier/North Holland Biomedical Press BV.  Pp. 157-172; 1981.

 

  1. Baron, S., Tyring, G. Klimpel, S. Barranco, M. Brysk, V. Gupta, and W. Fleischmann. Conditions for eradication of cultured tumor cells by interferon. In: Interferons.  Ed.:  T. Kishida.  Organizing committee of the International Symposium on Interferons.  Pp. 76-84; 1984.

 

  1. Fleischmann, W.R. Jr., G.R. Klimpel, K. Tyring, W.R. Voss, and S. Baron. Interferon and cancer: Current use and novel approaches. In:  Novel Approaches to Cancer Chemotherapy. Ed.:  P. Sunkara. Academic Press.  Pp. 1-22; 1984.

 

  1. Baron, S., Tyring, G. Klimpel, S. Barranco, M. Brysk, V. Gupta, and W.R. Fleischmann, Jr. Marked cytolysis of human tumor cells by interferon gamma and leukocytes. In:  Mediators in Cell Growth and Differentiation.  Eds.:  R.J. Ford and A.L. Maizel.  Raven Press.  Pp. 257-260; 1985.

 

  1. Baron, S., Tyring, C. Albrecht, W.R. Fleischmann, Jr., G. Klimpel, A. Bennett, M. Sarzotti, R. Sanchez, and W. Voss. Complete cytolysis of cultured human tumor cells by interferon gamma treated human peripheral blood mononuclear leukocytes. In: The Interferon System.  Eds.:  F. Dianzani and G.B. Rossi. Raven Press. Pp. 333-341; 1985.

 

  1. Baron, S., T.K. Hughes, M. Sarzotti-Kelsoe, G.R. Klimpel, W.R. Fleischmann, Jr., D. Weigent, G.J. Stanton, C. Albrecht, and Tyring. Interferon-mediated cytolysis of tumor cells.  In:  Interferons as Cell Growth Inhibitors and Antitumor Factors.  Eds: R.M. Friedman, T. Merigan, and T. Sreevalsan.  Alan R. Liss, Inc. pp. 447-453; 1986.

 

  1. Tyring, S., and S. Baron. Antitumor mechanisms of interferons. In:  The Interferon System, A Current Review. Eds.: S. Baron, F. Dianzani, G.J. Stanton, and W.R. Fleischmann, Jr.  University of Texas Press.  337-346; 1987.

 

  1. Tyring, S.K. Cutaneous vibrio infections.  In:  Clinical Dermatology. Eds. D.J. Demis, W. Bergdorf, E.B. Smith, and B.H. Thiers. Harper and Row, Unit 16-53; 1989.

 

  1. Tyring, S.K. Hemangiosarcoma and hemangioendotheliomas. In: Clinical Dermatology. Eds. D.J. Demis, W. Bergdorf, E.B. Smith, and B.H. Thiers. Harper and Row, Unit 7-71; 1989.

 

  1. Tyring, S.K. Interferon therapy of genital human papillomavirus infection. In: Clinical Practice of Gynecology.  : R. Richart and B. Winkler. Elsevier/North Holland Biomedical Press. Pp. 233-244; 1989.

 

  1. Tyring, S.K. Introduction to clinical uses of interferons. In: Interferon: Principles and Medical Applications. Eds.: S. Baron, D.H. Coppenhaver, F. Dianzani, W.R. Fleischmann, T.K. Hughes, G.R. Klimpel, D.W. Niesel, G.J. Stanton, and K. Tyring, University of Texas Medical Branch, Department of Microbiology, Galveston, TX, pp. 399-408; 1992.

 

  1. Tyring, S.K., and P.C. Lee. Protothecosis and Chlorellosis. In: Clinical Dermatology. Eds.: D.J. Demis, W. Bergdorf, E.B. Smith, and B.H. Thiers. J.B. Lippincott Co. Vol. 3, Section 17-30, pp. 1-5; 1993.

 

  1. Tyring, S.K. Herpes simiae infection. In: Clinical Dermatology. Eds.: D.J. Demis, W. Bergdorf, E.B. Smith, and B.H. Thiers.  B. Lippincott Co. Vol. 3, Section 14-5, pp. 1-4; 1993.

 

  1. Tyring, S.K. Viral diseases of the skin. In: Conn’s Current Therapy. Ed.: R.E. Rakel. W.B. Saunders Co. pp. 783-786; 1993.

 

  1. Tyring, S.K. Cellular immune responses in human papillomaviruses. In: Dermatology Progress and Perspectives. The Proceedings of the 18th World Congress of Dermatology. Eds.:  H.C. Burgdorf, S.I. Katz, A.F. Hood, F.D. Malkinson, M.S. Peters, J.K. Robinson, and R. Swerlick. Parthenon Publishing, London. Pp. 218-222; 1993.

 

  1. Cirelli, R.A., Rockley, P.F., and K. Tyring. Cytokine therapy of lower genital tract neoplasia. In: Intraepithelial Neoplasia of the Female Lower Genital Tract. Ed.: R. Richard. Churchill Livingston, London. Pp. 155-168; 1995.

 

  1. Tyring, S., R. Barbarash, A. Cunningham, J. Nahlik, J. Marley, M. Hong, T. Jones. T. Rea, and the Collaborative Famciclovir Herpes Zoster Clinical Study Group. Efficacy of Famvir (famciclovir) in herpes zoster: Impact on post-herpetic neuralgia (PHN). In: Proceedings of the Sixth International Congress Pain Clinic. Ed.: P.P. Raj. Monduzzi Editore, Bologna, Italy.

 

  1. Payne, D., P. Rockley, and K. Tyring. Diagnostic approaches to human papillomavirus disease. InCurrent Opinion Dermatol. 1:277-284; 1993.

 

  1. Herne, K., R. Cirelli, P. Lee, and K. Tyring. Current status of antiviral therapy. In: Current Opinion Dermatol. 3:195-201; 1996.

 

  1. McGinnis, M.R., and K. Tyring. General concepts of mycology. In: Medical Microbiology. Fourth Edition. Ed.: S. Baron. University of Texas Medical Branch at Galveston, Texas pp. 891-892; 1996.

 

  1. McGinnis, M.R., and K. Tyring. Introduction to mycology. In: Medical Microbiology. Fourth Edition. Ed: S. Baron.  University of Texas Medical Branch at Galveston, Texas, pp. 894-902; 1996.

 

  1. Tyring, S.K. Infections involving the skin. In: Clinical Virology. Eds.: D. Richman, R.J. Whitley and F.G. Hayden. Churchill Livingston International, New York, pp.127-147; 1996.

 

  1. Payne, D. and K. Tyring. Enhancing PCR sensitivity and specificity by optimizing the buffer components and pH. In: PCR: Essential Techniques. Ed.: J. Burke. Bios Scientific Publishers, Oxford, pp. 11-13; 1996.

 

  1. Chopra, K.F., P.C. Lee, and K. Tyring. Introduction to virus infections.  In: Clinical Dermatology.  Eds. D.J. Demis, W. Bergdorf, E.B. Smith, and B.H. Thiers.  Harper and Row. Vol. 3, Section 14-0, pp. 1-16; 1997.

 

  1. Chopra, K.F., P.C. Lee, and K. Tyring. Herpes simplex. In: Clinical Dermatology. Eds. D.J. Demis, W. Bergdorf, E.B. Smith, and B.H. Thiers.  Harper and Row. Vol. 3, Section 14-2, pp. 1-21; 1997.

 

  1. Chopra, K.F., P.C. Lee, and K. Tyring. Kaposi’s varicelliform eruption. In: Clinical Dermatology.  Eds. D.J. Demis, W. Bergdorf, E.B. Smith, and B.H. Thiers.  Harper and Row.  Vol. 3, Section 14-3, pp. 1-7; 1997.

 

  1. Evers, B.M., C.M. Townsend, K. Tyring, S.C. Hurlbut, T. Uchida, and J.C. Thompson. Polyamines and human carcinoid: Suppression of growth with combinations of a-difluoromethylornithine, somatostatin and interferon. In: Proceedings of the 62nd Falk Symposium. Eds.: R. H. Dowling, U.R. Folsch, and C. Loser. Kluwer Academic Publishers, pp. 335-345.

 

  1. Cirelli, R., K. Herne, M. McCrary, and K. Tyring. Adverse effects of interferons. In: Interferon Therapy of Multiple Sclerosis. Ed: A.T. Reder.  Marcel Dekker, Inc., New York, pp. 445-478; 1997.

 

  1. Chopra, K., Glidden, A., Lee, P. and Tyring, S.K. Second generation antiherpes drugs: valaciclovir and famciclovir.  In: Cutaneous Infection and Therapy.  Eds: R. Aly, K. Beutner, and H. Maibach.  Marcel Dekker, Inc., Chapter 35, pp. 441-450 ; 1997.

 

  1. Glidden, A., Chopra, K., Lee, P. and Tyring, S.K. Interferons for treatment of genital warts.  In:  Cutaneous Infection and Therapy. Eds: R. Aly, K. Beutner, and H. Maibach. Marcel Dekker, Inc., Chapter 36, pp. 451-460 ; 1997.

 

  1. Chopra, K.F. and K. Tyring. Current antiretroviral therapy in the treatment of human immunodeficiency virus infections. In: Seminars Cutan. Med. Surg. 16:224-234; 1997.

 

  1. Gross, G.E., K. Tyring, G. von Krogh, and R. Barrasso. External genitalia: treatment. In: Human Papillomavirus Infection: A Clinical Atlas. Ed.: G. Gross and R. Barrasso.  Ullstein Mosby, Wiesbaden, pp. 363-376; 1997.

 

  1. Baker, G.E, and K. Tyring. Therapeutic approaches to papillomavirus infections. In: Dermatology Clinics: Infections Diseases in Dermatology. Ed.: N.S. Sadick, Saunders, Philadelphia, pp. 331-340; 1997.

 

  1. McCrary, M.L., M.S. Patterson, and K. Tyring. In: Diagnosis and Treatment of Skin Infections. Ed.: M. Harahap.  Blackwell Science, London, pp. 197-257; 1997.

 

  1. Thandi, A., and K. Tyring. Newer aspects of herpes virus infection. In: Current Opinion in Dermatology. 4:42-50; 1997.

 

  1. McCrary, M.L., O.M. Memar, and K. Tyring. Antiviral agents. In: Immunomodulatory and Cytotoxic Agents in Dermatology. Ed.: C.J. McDonald, Marcel Dekker Inc., New York, pp. 47-58; 1997.

 

  1. Memar, O.M., K. Tyring, and M.L. McCrary. Treatment of cutaneous viral infections. In: Immunomodulatory and Cytotoxic Agents in Dermatology. Ed.: C.J. McDonald, Marcel Dekker, Inc., New York, pp. 345-365; 1997.

 

  1. Yen, A., and K. Tyring. Tumor-stromal interactions in cutaneous carcinogenesis. In: Cutaneous Oncology: Pathophysiology, Diagnosis and Treatment. Eds.: S.J. Miller and M.K. Maloney. Blackwell Science Inc. Cambridge, MA., pp. 98-109 ; 1998.

 

  1. Christian, M., T.Y. Evans, and K. Tyring. Human papillomavirus infection.  In:  Atlas of Infections of the skin.  Eds. R. Aly and H. Maibach. Churchill Livingston, New York, NY, pp. 219-230; 1999.

 

  1. Braathen, L.R., W.N. Meigel, E. Tschachler, K. Tyring, and G. Zambruno. Chair’s summary:  HIV and the skin-mechanisms of disease.  InDermatology at the Millennium: The Proceedings of the 19th World Congress of Dermatology.  Eds.:  D. Dyall-Smith and R. Marks.  Parthenon Publishing Co., New York, pp. 786-787; 1999.

 

  1. Evans, T., M.R. Vander Straten, D.A. Carrasco, S. Carlton, and K. Tyring. Systemic antiviral agents in dermatology. In: Comprehensive Dermatologic Drug Therapy. Ed.:  S. Wolverton.  Saunders, Philadelphia, pp. 85-106; 2001.

 

  1. Yen-Moore, A., R. Vinik, and K. Tyring. Human papillomavirus transmission and epidemiology patterns.  InProceedings of the Fourth International Multidisciplinary Congress:  Eurogin 2000.  Ed.:  J. Monsonego.  Monduzzi Editore, Bologna, Italy, pp. (suppl.) 6-17; 2000.

 

  1. Tyring, S.K. Human papillomavirus immunology and immunomodulators.  InProceedings of the Fourth International Multidisciplinary Congress:  Eurogin 2000.  :  J. Monsonego.  Monduzzi Editore, Bologna, Italy, pp. (supp.) 18-33; 2000.

 

  1. Tyring, S.K. Immunological processes in HPV infection and development of immunomodulating therapies.  In:  Proceedings of the Fourth International Multidisciplinary Congress:  Eurogin 2000.  : J. Monsonego.  Monduzzi Editore, Bologna, Italy, pp. 159-165; 2000.

 

  1. Severson, J.L., Beutner, K.R., and K. Tyring. Genital Papillomavirus Infection.  In: Sexually Transmitted Diseases:  Vaccines, Prevention and Control. Eds.: L. Stanberry and D. Bernstein. Academic Press, San Diego, CA. pp.259-272; 2000.

 

  1. Yen-Moore, A., and K. Tyring. Cutaneous warts.  In:  Human Papillomaviruses: Clinical and Scientific Advances.  Eds.: J.C. Sterling and S.K. Tyring.  Oxford University Press, London, U.K.  pp. 52-59;  2001.

 

  1. Trizna, Z., and K. Tyring. Respiratory papillomatosis.  In: Human Papillomaviruses: Clinical and Scientific Advances.  Eds.:  J.C. Sterling and S.K. Tyring.  Oxford Press University, London, U.K.  pp. 82-89;  2001.

 

  1. Tyring, S.K. Basic research.  In:  Human Papillomaviruses:  Clinical and Scientific Advances.  :  J.C. Sterling and S.K. Tyring.   Oxford Press University, London, U.K. pp. 139-148; 2001.

 

  1. Vander Straten, M., D. Carrasco, and K. Tyring. Viral infection involving the skin.  InClinical Virology.  Eds:  D.D. Richman, R.J. Whitley and F.G. Hayden. ASM Press, Washington, D.C.  pp. 117-134; 2002.

 

  1. Mendoza, N. A. Arora, C.A. Arias, A.J. Gewirtzman and K. Tyring. Immunodermatology and viral skin infection. In: Clinical and Basic Immunodermatology (1st ed). Eds. A.A. Gaspari and S.K. Tyring. Springer Verlag, London. pp. 297-322; 2008.

 

 

  1. Arora, A. N. Mendoza, A.M. Tremaine and K. Tyring. Vaccines. In: Clinical and Basic Immunodermatology (1st ed). Eds. A.A. Gaspari and S.K. Tyring. Springer Verlag, London. pp. 579-604; 2008.

 

 

  1. Tyring, S.K. Introduction to viral diseases.  In:  Mucocutaneous Manifestations of Viral Diseases.  S.K. Tyring.  Marcel Dekker,Inc.,  New York, pp. 1-24; 2002 (1st edition); Cutaneous Virology; pp. 1-19; 2010 (2nd edition).

 

  1. Memar, O., I. Arany, and K. Tyring. Cutaneous resistance to viral infections.  In:  Mucocutaneous Manifestations of Viral Diseases.  Ed.:  S.K. Tyring.  Marcel Dekker, Inc., New York, pp. 25-38; 2002 (1st edition); pp. 20-35; 2010 (2nd edition).

 

  1. McCrary, M., and K. Tyring. Varicella zoster virus.  In:  Mucocutaneous Manifestations of Viral Diseases.  Ed.:  S.K. Tyring.  Marcel Dekker, Inc.,  New York, pp. 119-144; 2002 (1st edition); pp. 98-122; 2010 (2nd edition).

 

  1. Boldogh, I., J. Patel, K. Tyring, and T. Chonmaitree. Cytomegalovirus.  In:  Mucocutaneous Manifestations of Viral Diseases.  Ed.:  S.K. Tyring.  Marcel Dekker, Inc., New York, pp. 173-195 (1st edition); pp. 145-164; 2010 (2nd edition).

 

  1. Brown, T., A. Yen-Moore, and K. Tyring. Herpes virus 8.  In:  Mucocutaneous Manifestations of Viral Diseases.  Ed.:  S.K. Tyring.  Marcel Dekker, Inc., New York, pp. 219-234; 2002(1st edition); pp. 184-197; 2010 (2nd edition).

 

  1. Rockley, P., and K. Tyring. Herpes virus B.  In:  Mucocutaneous Manifestations of Viral Diseases.  Ed.:  S.K. Tyring.  Marcel Dekker, Inc., New York, pp. 235-245; 2002(1st edition); pp. 198-206; 2010 (2nd edition).

 

  1. Stalkup, J.R., K. Yeung-Yue, M. Brentjens and K. Tyring. Human herpesviruses. In: Dermatology. Eds.: J.L. Bolognia, J.L. Jorizzo and R.P. Rapini. Mosby, London, pp. 1235-1252; 2003.

 

  1. Carrasco, D.A. and K. Tyring. Skin and soft tissue infections. In: Antibiotic and Chemotherapy (8th edition). Eds.: R.G. Finch, D. Greenwood, S.R. Norrby and R.J. Whitley. Churchill Livingston, Philadelphia, pp. 692-707; 2003.

 

  1. Torres, G. and K. Tyring. Antivirals. In: Handbook of Drug Allergy. Eds.: R.W. Honsinger and G.R. Green. Lippincott, Williams and Wilkins, Philadelphia, pp. 38-44; 2003.

 

  1. Yeung-Yue, K.A., G. Torres, M.H. Brentjens, P.C. Lee and K. Tyring. Herpes simplex virus. In: Viral Infections and Treatment. Eds.: H. Rubsamen-Waigmann, K. Deres, G. Hewlett and R. Welker. Marcel Dekker, New York, pp. 165-192; 2003.

 

  1. Wu, J.J., K.A. Yeung-Yue, M.H. Brentjens and K. Tyring. Varicella-zoster virus. In: Viral Infections and Treatment. Eds.: H. Rubsamen-Waigmann, K. Deres, G. Hewlett and R. Welker. Marcel Dekker, New York, pp. 193-225; 2003.

 

  1. Torres, G. and K. Tyring. Hair loss. In: Primary Care for Women. Eds.: P. Leppert and J.F. Peipert. Lippincott, Williams and Wilkins, Philadelphia, pp. 835-843; 2004.

 

  1. Torres, G. and K. Tyring. Herpes simplex and herpes zoster. In: Primary Care for Women. Eds.: P. Leppert and J.F. Peipert. Lippincott, Williams and Wilkins, Philadelphia, pp. 853-859; 2004.

 

  1. Torres, G. and K. Tyring. Human papillomavirus infections (warts). In: Primary Care for Women. Eds.: P. Leppert and J.F. Peipert. Lippincott, Williams and Wilkins, Philadelphia, pp. 859-861; 2004.

 

  1. Brentjens, M.H., K.A. Yeung-Yue, P.C. Lee and K. Tyring. Human papillomaviruses and warts. In: Infectious Diseases. (3rd Edition). Eds: S.L. Gorbach, J.G. Bartlett and N.R. Blacklow. Lippincott, Williams and Wilkins, Philadelphia, chapter 142, pp. 1215-1219; 2004.

 

  1. Tyring, S.K. Syndromal tropical dermatology. In: Tropical Dermatology. Eds: K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 1-12; 2006 (1st ed); pp. 1-13; 2017 (2nd ed).

 

  1. Lupi, O. and Tyring, S.K. Old world hemorrhagic fevers. In: Tropical Dermatology. Eds: K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 125-132; 2006 (1st ed); pp. 128-135; 2017 (2nd ed).

 

  1. Wu, J.J., K.R. Pang, D.B. Huang and K. Tyring. Tropical manifestations of common viral infections. In: Tropical Dermatology. Eds: S.K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 171-184; 2006 (1st ed). R. Kollipara and S.K. Tyring. pp. 178-188; 2017 (2nd ed).

 

  1. Pang, K.R., J.J. Wu, D.B. Huang, R. de Sousa, F. Bacellar and K. Tyring. Rickettsial infections. In: Tropical Dermatology. Eds: S.K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 279-296; 2006 (1st ed). R. Kollipara and S.K. Tyring. pp. 280-282; 2017 (2nd ed).

 

  1. Tyring, S.K. In: Tropical Dermatology. Eds: S.K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 359-360; 2006 (1st ed); pp. 359-361; 2017 (2nd ed).

 

  1. Tyring, S.K. In: Tropical Dermatology. Eds: S.K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 361-363; 2006 (1st ed); pp. 362-364; 2017 (2nd ed).

 

  1. Tyring, S.K. Miscellaneous bacteria. In: Tropical Dermatology. Eds: K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 372-374; 2006 (1st ed); pp. 372-375; 2017 (2nd ed).

 

  1. Brentjens, M. H., K.K. Sra, V. Haddad Junior, P. Lee and K. Tyring. Marine/freshwater dermatology. In: Tropical Dermatology. Eds: S.K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp. 455-468; 2006 (1st ed). V. Haddad and S.K. Tyring. pp. 460-470; 2017 (2nd ed).

 

  1. Madkan, V., K. Sra and K. Tyring. The role of mucosal immunity in protection against viral diseases. In: Mucosal Immunology and Virology. Ed: S.K. Tyring. Springer, London, pp. 1-6; 2006.

 

  1. Bartell, H. and K. Tyring. Viral diseases. In: Dermatology: A Pictorial Review. Ed: A. Ali. McGraw-Hill, pp. 253-270; 2007.

 

  1. Tyring, S.K. , V.K. Madkan, A. Arora and N. Mendoza. Viral Infections: Overview. In: Clinical Management of Uncomplicated Skin and Skin-Structure Infections. Eds: D.M. Elston and R.K. Scher. Professional Communications, Inc., New York, pp. 91-92; 2007.

 

  1. Tyring, S.K. , V.K. Madkan, A. Arora and N. Mendoza. Herpes simplex. In: Clinical Management of Uncomplicated Skin and Skin-Structure Infections. Eds: D.M. Elston and R.K. Scher. Professional Communications, Inc., New York, pp. 93-102; 2007.

 

  1. Tyring, S.K. , V.K. Madkan, A. Arora and N. Mendoza. Varicella zoster. In: Clinical Management of Uncomplicated Skin and Skin-Structure Infections. Eds: D.M. Elston and R.K. Scher. Professional Communications, Inc., New York, pp. 103-114; 2007.

 

  1. Tyring, S.K. , V.K. Madkan, A. Arora and N. Mendoza. Molluscum contagiosum. In: Clinical Management of Uncomplicated Skin and Skin-Structure Infections. Eds: D.M. Elston and R.K. Scher. Professional Communications, Inc., New York, pp. 115-119; 2007.

 

  1. Tyring, S.K. , V.K. Madkan, A. Arora and N. Mendoza. Variola. In: Clinical Management of Uncomplicated Skin and Skin-Structure Infections. Eds: D.M. Elston and R.K. Scher. Professional Communications, Inc., New York, pp. 121-124; 2007.

 

  1. Tyring, S.K. , V.K. Madkan, A. Arora and N. Mendoza. Condyloma. In: Clinical Management of Uncomplicated Skin and Skin-Structure Infections. Eds: D.M. Elston and R.K. Scher. Professional Communications, Inc., New York, pp. 125-130; 2007.

 

  1. Berthelot, C.N. and K. Tyring. Viral oncogenesis. In: Molecular Pathology of Lung Diseases. Eds. D.S. Zander, H.H. Popper, J. Jagirdar, A.K. Haque, P.T. Cagle and R. Barrios. Springer Verlag, Berlin. pp. 240-250; 2008.

 

  1. Arora, A., N. Mendoza, A. Motta, V. Madkan and K. Tyring. Viral diseases. In: Infectious Diseases of the Skin. Ed. D. M. Elston. Manson Publishing, Washington, D.C. pp. 60-83; 2009.

 

  1. Amin, S., A.J. Gewirtzman and K. Tyring. Clean and aseptic technique at the bedside. In: Emergency Dermatology. Eds: R. Wolf, B.B. Davidovici, J.L. Parrish and L.C. Parish. Cambridge University Press, Cambridge, U.K. (1st ed): pp. 12-17; 2010. Hashmi, O., R. Kollipara and S.K. Tyring. (2nd ed): pp. 10-14; 2017.

 

  1. Gewirtzman, A.J., B. Christianson, A.M. Tremaine, B.L. Pellicane and K. Tyring. Life-threatening cutaneous viral diseases. In: Emergency Dermatology. Eds: R. Wolf, B.B. Davidovici, J.L. Parrish and L.C. Parish. Cambridge University Press, Cambridge, U.K. (1st ed): pp. 115-125; 2010. Turkeltaub, A.E., R. Kollipara and S.K. Tyring. (2nd ed): pp. 114-123; 2017.

 

  1. Satyaprakash, A., P. Ravanfar and K. Tyring. Dermatologic virology. In: Sauer’s Manual of Skin Diseases (10th ed). Eds: B.J. Hall and J.C. Hall. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia. pp. 230-239; 2010. Peranteau, A.J., Y. Tong, Z.Y. Nawas and S.K. Tyring. (11th ed); pp. 263-277.

 

  1. Lozano, A., A. Arora, N. Mendoza, V. Madkan and K. Tyring. Viral infections. In: Therapy of Skin Diseases. Eds.: T. Krieg, D.R. Bickers and Y. Mitachi. Springer Verlag, Berlin, pp. 157-164; 2010.

 

  1. Bartlett, B. and K. Tyring. Reoviridae. In: Mucocutaneous Manifestations of Viral Diseases. Eds: S.K. Tyring, A.Yen Moore and O. Lupi. Informa Healthcare, London, pp. 349-353; 2010 (2nd edition).

 

  1. Conner, K.B. and K. Tyring. Enteroviruses. In: Mucocutaneous Manifestations of Viral Diseases. Eds: S.K. Tyring, A. Yen Moore and O. Lupi. Informa Healthcare, London, pp. 407-418; 2010 (2nd edition).

 

  1. Faber, W.R., H.J.C. de Vries and K. Tyring. Togaviruses. In: Mucocutaneous Manifestations of Viral Diseases. Eds: S.K. Tyring, A. Yen Moore and O. Lupi, Informa Healthcare, London, pp. 447-465; 2010 (2nd edition).

 

  1. Satyaprakash, A.K., P. Ravanfar and K. Tyring. Skin and soft-tissue infections. In: Antibiotic and Chemotherapy (9th ed). Eds. R.G. Finch, D. Greenwood, S.R. Norrby and R.J. Whitley. Elsevier, London, pp. 617-632; 2010.

 

  1. Gewirtzman, A., L. Bobrick, K. Conner and K. Tyring. Epidemiology of Sexually Transmitted Infections. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 13-34; 2011.

 

  1. Gill, A.R., P. Ravanfar, N. Mendoza and K. Tyring. Sexual Behavior and Psychological Aspects Associated With Sexually Transmitted Infections. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 35-42; 2011.

 

  1. Mendoza, N., A. Motta, B.L. Pellicane, P. Ravanfar and K. Tyring. Syphilis and HIV. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 173-182; 2011.

 

  1. Mendoza, N., P. Ravanfar, A.K. Shetty, B.L. Pellicane, R. Creed, S. Goel and K. Tyring. Genital Mycoplasma Infection. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp.197-202; 2011.

 

  1. Creed, R., A.K. Shetty, P. Ravanfar and K. Tyring. STDs and Travel Medicine. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 627-636; 2011.

 

  1. Shetty, A.K., D.G. Desai, J. Wilson and K. Tyring. Therapy-New Drugs. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 637-650; 2011.

 

  1. Diamantis, M.L. and K. Tyring. Viral Hepatitis Vaccines. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 671-680; 2011.

 

  1. Ravanfar, P., N. Mendoza, A.K. Shetty, R. Creed and K. Tyring. HSV Prevention. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 693-702; 2011.

 

  1. Ravanfar, P., N. Mendoza, A.K. Shetty, R. Creed and K. Tyring. HIV Prevention. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 703-714; 2011.

 

  1. Conner, K.B., A.J. Gewirtzman and K. Tyring. Physical Barrier Methods and Microbicides. In: Sexually Transmitted Infections and Sexually Transmitted Diseases. Eds: G. Gross and S.K. Tyring, Springer Verlag, Berlin, pp. 741-748; 2011.

 

  1. Patel, T., L.K. Morrison, N. Mendoza and K. Tyring. Treatment of herpes simplex. In: Evidence Based Dermatology (2nd ed). Eds. H.I. Maibach and F. Gorouhi. People’s Medical Publishing House, Shelton, CT. pp.. 327-336; 2011.

 

  1. Morrison, L.K. and K. Tyring. Viral infections and skin cancer. In: Evidence Based Dermatology (2nd ed.). Eds. H.I. Maibach and F. Gorouhi. People’s Medical Publishing House, Shelton, CT. pp.891-903; 2011.

 

  1. Willison, C.B., L.K. Morrison, N. Mendoza and K. Tyring. Treatment of viral infections. In: HIV/AIDS in the Post-HAART Era. Eds. J.C. Hall, B.J. Hall and C.J. Cockerell. People’s Publishing House, Shelton, CT. pp. 404-449; 2011.

 

  1. Bhuchar, S., L.K. Morrison and K. Tyring. Venereal diseases. In: Hall’s Manual of Skin as a Marker of Underlying Disease. Eds. J.C. Hall and B.J. Hall. People’s Medical Publishing House. Shelton, CT. pp. 421-430; 2011.

 

  1. Arora, A., N. Mendoza and K. Tyring. Antiviral market overview. In: Development of Therapeutic Agents Handbook. Ed. S.C. Gad. Wiley, Hoboken, N.J. pp. 127-143; 2012.

 

  1. Morrison, L.K., A. Ahmed, V. Madkan, N. Mendoza and K. Tyring. General considerations of viral diseases. In: Fitzpatrick’s Dermatology in General Medicine (8th ed.). Eds. L.A. Goldsmith, S.L. Katz, B.A. Gilchrest, A.S. Paller, D.J. Leffell and K. Wolff. McGraw-Hill, New York. pp. 2329-2336; 2012.

 

  1. Mays, R.M., R.A. Gordon, S. Javed, J.M. Wilson, W.J. LaPolla, N.A. Kjar and K. Tyring. In: Imported Skin Diseases (2nd ed.). Eds. W.R. Faber, R.J. Hay and B. Naafs. Wiley-Blackwell, Oxford. pp. 123-148; 2013.

 

  1. Magel, G.D., K.A. Haitz, W.J. LaPolla, C.M. DiGiorgio, N. Mendoza and K. Tyring. Systemic antiviral agents. In: Comprehensive Dermatologic Drug Therapy (3rd ed.). Ed. S.E. Wolverton. Elsevier, London. pp. 121-134; 2013.

 

  1. Mayo, T.T., R. Imtiaz, H. Doan, B.L. Sambrano, R. Gordon, M. K. Ramirez-Fort and K. Tyring. Human papillomavirus: epidemiology and clinical features of related cancer. In: Viruses and Human Cancer. Ed. S.D. Hudnall. Springer, New York. pp. 199-228; 2014.

 

  1. Gordon, R. and K. Tyring. Herpes simplex virus. In: Acneiform Eruptions in Dermatology: A Differential Diagnosis. Ed. J.A. Zeichner. Springer, New York. pp. 85-94; 2014.

 

  1. Gordon, R. K. Tyring, W. LaPolla and R. Mays. Varicella zoster virus. In: Acneiform Eruptions in Dermatology: A Differential Diagnosis. Ed. J.A. Zeichner. Springer, New York. pp. 95-106; 2014.

 

  1. Khan, F., R.M. Mays, J. Brooks and K. Tyring. Viral and sexually transmitted disease. In: Text Atlas of Obstetric Dermatology. Ed. G. Kroumpouzos. Wolters Kluwer, Philadelphia. pp. 126-140; 2014.

 

  1. Gordon, R., R.M. Mays and K. Tyring. Herpes genitalis. In: Treatment of Skin Disease (4th ed.). Eds. M.G. Lebwohl, W.R. Heymann, J. Berth-Jones and I. Coulson. Elsevier, London. pp. 304-307; 2014.

 

  1. Mays, R.M., E.T. Petersen, R.A. Gordon and K. Tyring. Herpes zoster. In: Treatment of Skin Disease (4th ed.). Eds. M.G. Lebwohl, W.R. Heymann, J. Berth-Jones and I. Coulson. Elsevier, London. pp. 311-313; 2014.

 

  1. Doan, H., M. K. Ramirez-Fort, R. J. Gertz, A. J. Thompson, F. Khan and K. Tyring. Disorders of fat. In: Dermatology: Specialty Board Review (3rd ed.). Ed. A. Ali. McGraw-Hill, New York. pp. 175-190; 2015.

 

  1. Mays, R.M., R.A. Gordon, W.L. DeLozier, N. Mendoza and S.K. Tyring. Viral Diseases. In: Dermatology: Specialty Board Review (3rd). Ed. A. Ali. McGraw-Hill, New York. pp. 299-332; 2015.

 

  1. Ramirez-Fort, M., R.Z. Robinson, R.J. Gertz, H. Doan, J. Constantino, F. Khan and K. Tyring. Nutrition-related diseases. In: Dermatology: Specialty Board Review (3rd ed.). Ed. A. Ali. McGraw-Hill, New York. pp. 381-394; 2015.

 

  1. Tyring, S.K. Acyclovir: The first antiviral. In: To Heal the Skin. W.S. Maddin and H.E. Murray. Linacre’s Books, Toronto, Ont. Pp. 9-15; 2015.

 

 

 

  1. Thompson, A.J., E. Ojeaga, M. K. Ramirez-Fort, H.P. Nguyen, F. Khan and Tyring, S.K. Mucocutaneous Viral Infections. In: Dermatology for Skin of Color (2nd ed). Eds. S. Taylor, P. Kelly, H. Lim and A. Serrano. McGraw Hill, New York. pp. 437-446; 2016.

 

  1. Peranteau, A.J. and K. Tyring. Herpes Simplex Virus Type 1, Type 2, Genital Herpes. In:, Clinical Decision Support: Dermatology (2nd ed). Eds. W. R. Heymann, B. E. Anderson, D. DeHoratius & C. V. Hivnor Wilmington: Decision Support in Medicine, LLC; 2016.

 

  1. Peranteau, A.J. and K. Tyring. Cytomegalovirus Infection. In: Clinical Decision Support: Dermatology (2nd ed). Eds.W. R. Heymann, B. E. Anderson, D. DeHoratius & C. M. Hivnor  Wilmington: Decision Support in Medicine, LLC; 2016.

 

  1. Peranteau, A.J., and K.Tyring. Herpes Zoster. In: Clinical Decision Support: Dermatology (2nd ed). Eds.W. R. Heymann, B. E. Anderson, D. DeHoratius, & C.M. Hivnor Wilmington: Decision Support in Medicine, LLC; 2016.

 

  1. Peranteau, A.J. and K. Tyring. Varicella. In: Clinical Decision Support: Dermatology (2nd ed). Eds.W. R. Heymann, B. E. Anderson, D. DeHoratius, & C. M. Hivnor  Wilmington: Decision Support in Medicine, LLC; 2016.

 

  1. Tyring, S.K. In: Tropical Dermatology (2nd ed). Eds. S.K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp.77-78; 2017.

 

  1. Tyring, S.K. Ehrlichioses. In: Tropical Dermatology (2nd ed). Eds. K. Tyring, O. Lupi and U.R. Hengge. Elsevier, London, pp.297-302; 2017.

 

  1. Kollipara, R., C. Downing, J. Guidry, M. Lee, N. Mendoza, C. Arias, A. Peranteau and K. Tyring. Immunodermatology and viral skin infection. In: Clinical and Basic Immunodermatology (2nd ed). Eds. A.A. Gaspari, S.K. Tyring and D.H. Kaplan. Springer Verlag, London. pp. 289-312; 2017.

 

  1. Guidry, J. R. Kollipara, C. Downing, M. Lee and K. Tyring. Fungal infections. In: Clinical and Basic Immunodermatology (2nd ed). Eds. A.A. Gaspari, S.K. Tyring and D.H. Kaplan. Springer Verlag, London. pp. 325-358; 2017.

 

 

  1. Kollipara, R. Shane, S. Shah and S.K. Tyring. Iatrogenic immunodeficiency and skin disease. In: Clinical and Basic Immunodermatology (2nd ed). Eds. A.A. Gaspari, S.K. Tyring and D.H. Kaplan. Springer Verlag, London. pp. 685-694; 2017.

 

  1. Lee, M., C. Downing, R. Kollipara, J. Guidry and K. Tyring. Vaccines. In: Clinical and Basic Immunodermatology (2nd ed). Eds. A.A. Gaspari, S.K. Tyring and D.H. Kaplan. Springer Verlag, London. pp. 831-856; 2017.

 

 

 

 

 

  1. MONOGRAPHS

 

  1. Tyring, S.K., and R. Sadovsky. Management of herpesvirus infections. American Family Physician Monograph 2:1-24; 1996.

 

 

  1. BOOKS EDITED

 

  1. Interferon: Principles and Medical Applications. S. Baron, D.H. Coppenhaver, F. Dianzani, W.R. Fleischmann, T.K. Hughes, G.R. Klimpel, D.W. Niesel, G.J. Stanton, and K. Tyring, eds. University of Texas Medical Branch, Department of Microbiology, Galveston, TX, 1992.

 

  1. Human Papillomaviruses. Sterling, and S.K. Tyring, eds.  Oxford Press University, London, U.K.  pp. 1-153; 2001. (reviewed in Arch. Dermatol. 139: 677-678; 2003).

 

  1. Mucocutaneous Manifestations of Viral Diseases. K. Tyring, ed. Marcel Dekker, Inc., New York, pp. 1-574; 2002 (1st ed). (reviewed in N. Engl. J. Med. 349: 719-720; 2003); Informa Healthcare, London, pp. 1-536; 2010 (2nd ed).

 

  1. Antiviral Agents, Vaccines and Immunomodulatory Drugs. K. Tyring, ed. Marcel Dekker, Inc., New York, pp. 1-424; 2005. (reviewed in Ann. Intern. Med. 142: 686; 2005).

 

  1. Tropical Dermatology. K. Tyring, O. Lupi, and U. Hengge, eds.  Elsevier Science Ltd., London, pp. 1-515; 2006 (1st ed). pp. 1-491; 2017 (2nd ed).

 

  1. Mucosal Immunology & Virology. K. Tyring, ed.  Springer Verlag, London, pp. 1-212; 2006.

 

  1. Clinical and Basic Immunodermatology. A. Gaspari and K. Tyring, eds. Springer Verlag, London, pp. 1-880; 2008 (1st ed). A. Gaspari, S.K. Tyring and D.H. Kaplan, eds. pp. 1-895; 2017 (2nd ed).

 

  1. Sexually Transmitted Diseases. Gross and S.K. Tyring, eds. Springer Verlag, London, pp. 1-925; 2011.

 

  1. Herpesviridae. G.D. Magel and K. Tyring, eds. Intech, Rijeka, pp. 1-320; 2012.

 

  1. Human Papillomavirus: Bench to Bedside. M.K. Ramirez-Fort, F. Khan, P.L. Rady and K. Tyring, eds. Karger, Basel, pp. 1-272; 2014.

 

 

 

 

ABSTRACTS

 

More than 1000 published abstracts.

 

 

PRESENTATIONS

 

More than 1000 national and international presentations by Dr. Tyring and by research faculty, postdoctoral fellows, graduate and medical students who worked in Dr. Tyring’s laboratory and/or research clinics.

Presentations Time:

Session code and title Session 12: Skin infections
Presentation title Emerging infectious diseases
Session date Wednesday 25 April 2018
Session time 15.00-17.00
Venue Feyz Hall (C)

 

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